22 results about "Neurogenic Urinary Bladder" patented technology

The present invention provides a prophylactic or therapeutic agent for accompanying symptoms associated with diseases caused by spinal marrow or brain disorders, such as spinal marrow injury or HTLV-1-associated spinal marrow disease, which contains an RGMa inhibitor. Also provided is a prophylactic or therapeutic agent for spasmodic or neurogenic bladder, said prophylactic or therapeutic agent containing an RGMa inhibitor.

The present invention relates to a composition for preventing or treating bladder diseases, a composition for preventing or treating neuropathic pain, neuroinflammation or inflammatory skin diseases, or the therapeutic use of a novel compound YJ102, the compound YJ102 of the present invention inhibits neuropathic pain due to various reasons, ameliorates urination disorders due to spinal cord injury, restores bladder hypertrophy and bladder function, inhibits erythema and keratinogenesis, which are main symptoms of psoriasis, in a psoriasis animal model, and has a superior effect than conventional drugs. The composition can inhibit increase of the thickness of the epidermal layer and spleen hypertrophy caused by psoriasis, and can be used for treating various difficult nervous system diseases or bladder diseases.

Devices and methods for evaluating and treating neurogenic bladder (NB) are disclosed. In some embodiments, a probe may include microneedles for gently puncturing the bladder detrusor tissue of a test subject. The microneedles may non-invasively collect a series of electric impedance myography (EIM) measurements to evaluate the condition of the bladder and assist in diagnosis. In some embodiments, the probe may provide information regarding the tissue's structural and biophysiological condition, in a real-time, quantitative, and objective manner. In some embodiments, the probe may assist in identifying optimal treatment (e.g., Botox or biomaterials injection) sites for NB by providing real-time results.

The invention relates to the technical field of bladder internal pressure monitoring and management, and provides a neurogenic bladder internal pressure monitoring and management system based on incremental learning, which comprises a data acquisition module, an embedded hardware platform and a user side prompt module. The data acquisition module is responsible for acquiring physiological parameter information such as bladder internal pressure, abdominal pressure and body position angle in real time. The bladder internal pressure prediction module integrated by the embedded hardware platform establishes a pressure-time relationship in a piecewise linear modeling mode, continuously adjusts model parameters by applying an incremental learning algorithm, and generates prediction data in a future time window; and the multi-modal state identification module receives the prediction data and the current multi-source physiological information, performs comprehensive analysis by applying a fuzzy logic reasoning mechanism, identifies and eliminates the influence of instantaneous interference factors, and outputs the grade evaluation of the bladder state. And the user side prompting module executes a grading early warning strategy according to the state grade and sends intervention prompting information of different emergency degrees to the patient.

The present invention relates to a novel compound YJ102 for the prevention or treatment of bladder diseases, a composition for the prevention or treatment of neuropathic pain, neuroinflammation, or inflammatory skin diseases, or for the treatment of intractable neurological diseases including neurogenic bladder. The compound YJ102 of the present invention suppresses neuropathic pain caused by various factors with superior efficacy compared to conventional drugs, improves urinary dysfunction caused by spinal cord injury, restores bladder enlargement and bladder function, suppresses the development of erythema and scaling, which are major symptoms of psoriasis in animal models of psoriasis, suppresses thickening of the epidermal layer, and suppresses splenomegaly caused by psoriasis. Therefore, it can be utilized for the treatment of various intractable neurological diseases or bladder diseases.

The application discloses a bladder drainage device which comprises a catheter, a bare sensing electrode, a bare sensing electrode connector, an inner flower crown anti-stone ballon, a heating electrode, a heating electrode connector, a bladder function regulating electrode, a bladder function regulating electrode connector, a left side water injection hole, a water injection catheter interface, a right side drainage hole, a water outlet catheter interface, an outer fixed balloon, an outer fixed balloon water injection hole and an inner flower crown anti-stone balloon water injection hole. The application has the advantages that the drainage device is integrated with the bare sensing electrode, the bladder function regulating electrode contact, the heating electrode and the anti-stone balloon, the diagnosis and treatment function modules are integrated, and the difficult problems that part of neurogenic bladder needs to frequently replace catheters, urine drainage is released and bladder function recovery is promoted can be solved.

Disclosed in the present invention are an electrical stimulation tactile evaluation method and system and wearable device for neurogenic bladder treatment. The system relates to the technical fields of non-invasive neuromodulation treatment and electrical stimulation tactile evaluation for neurogenic bladder. The method comprises: acquiring and analyzing neurogenic bladder treatment data, comprehensively analyzing same, and performing optimization adjustment. In the present invention, electrical pulses output by a stimulator unit are applied to specific neural electrodes, plantar motion signal features are acquired and decoded, neurogenic bladder treatment data is acquired and analyzed and the positions and stimulation parameters of the neural electrodes are thus adaptively adjusted, realizing non-invasive treatment of the neurogenic bladder, and solving the deficiencies of existing therapeutic technology.

The invention belongs to the field of medical tools, and provides a split type leakproof catheter which comprises an insertion tube, one end of the insertion tube is integrally and fixedly connected with a tip, the other end of the insertion tube is integrally and fixedly connected with a connecting tube, the connecting tube is used for being communicated with an input tube of a urine collection bag, and branch tubes fixedly penetrate through the side wall of the connecting tube in a central symmetry mode; a valve is installed on the branch pipe, urine inlet holes are formed in the position, close to the pointed end, of the insertion pipe in a central symmetry mode, an anti-disengaging piece used for preventing the insertion pipe from disengaging is arranged at the position, close to the urine inlet holes, of the insertion pipe, and the anti-disengaging piece comprises a water injection balloon fixedly connected to the insertion pipe. By means of the technical scheme, moderate pressure can be applied to the urethral wall through controllable inflation, closing performance is enhanced, urine leakage beside the insertion tube is reduced, the technology is particularly suitable for elderly women and neurogenic bladder or sphincter insufficiency patients, the urine leakage amount can be effectively reduced, and the occurrence rate of incontinence dermatitis caused by the fact that the skin of the patients is affected by urine is reduced.

The utility model relates to the technical field of alarm devices, in particular to a neurogenic bladder urination alarm device. Comprising an outer shell, a pressure sensor is fixed to the lower end in the outer shell, an inner shell is fixed to the upper end of the pressure sensor and located in the outer shell, a gap is formed between the outer edge of the inner shell and the inner edge of the outer shell, the lower end of the inner shell is fixedly communicated with a calandria, and the lower end of the calandria penetrates through a lower hole in the lower end of the outer shell; an upper hole concentric with the inlet pipe is formed in the upper end of the inner shell, the lower end of the inlet pipe penetrates through the upper hole, the upper end of the inlet pipe is fixedly communicated with the catheter, a valve is installed on the catheter, a flow sensor is installed on the inlet pipe, and an alarm is installed on the outer shell. By arranging the flow sensor, when urine flows through the inlet pipe, the flow sensor can detect the flow of the urine in the inlet pipe and transmit the monitored value to the displayer, and the urine flow is monitored to feed back the current urodynamic state of the bladder of a patient.

The invention relates to the technical field of medical treatment, in particular to a neurogenic bladder-anxiety coordinated regulation auxiliary system based on biofeedback, which comprises a biofeedback module used for collecting physiological signals of a patient, a signal processing module used for processing and analyzing the physiological signals, extracting characteristic parameters, and sending the characteristic parameters to a server; the regulation and control module is used for generating a regulation and control signal according to the characteristic parameters, the intervention execution module is used for intervening the bladder function and anxiety emotion of the patient according to the regulation and control signal, and the neural feedback training device is used for conducting brain wave feedback training on the patient according to the regulation and control signal. The user interaction interface is used for displaying the physiological signals and the regulation and control signals and allowing a user to input personalized settings and feedback information, and the data storage module is used for storing the physiological signals, the regulation and control signals, the personalized settings and the feedback information. According to the system, through the synergistic effect of biological feedback and neural feedback, a personalized and non-invasive adjuvant therapy scheme is provided for a neurogenic bladder patient.

The invention discloses a real-time pressure capacity monitoring and precise catheterization method and system for a neurogenic bladder, and belongs to the field of medical health, and the method comprises the steps: collecting bladder pressure data in real time through a wearable sensor, and carrying out filtering processing to obtain a clean pressure sequence; time sequence features are extracted, and a future pressure evolution path is predicted by adopting a long-short-term memory network; when the predicted path exceeds a safety threshold value, an intervention signal is generated, and individual difference historical data is fused to determine a personalized catheterization opportunity; and finally, outputting a catheterization prompt matched with the scene according to the activity state of the patient. The system correspondingly comprises a data acquisition module, a filtering processing module, a feature extraction module, a trend prediction module, an early warning judgment module, an opportunity determination module, a trigger sequence generation module and a reminding output module. According to the invention, continuous dynamic monitoring and accurate prediction of the bladder state are realized, individualized and scenarized urinary catheterization intervention prompts can be provided, and the safety and timeliness of neurogenic bladder management are effectively improved.

The application discloses a kind of for neurogenic bladder multimode monitoring device and use method, it is related to neurogenic bladder monitoring field, including flexible connection cloth, the two sides of the flexible connection cloth are respectively provided with elastic band one and elastic band two, the lower of the flexible connection cloth is provided with monitoring mechanism, and the monitoring mechanism includes elastic cloth;Through the setting of monitoring mechanism, effectively avoid the single sensing error caused by abdominal wall thickness, intestinal gas or subcutaneous fat distribution difference, and the consistency of two-way data is judged by wireless signal concentrated transmission module, and only when the deviation is within the allowable range, the fusion result is output, which greatly improves the measurement reliability, the device adopts solid hydrogel and ultrasonic patch sensor integrated structure, to ensure stable acoustic coupling under long-time wearing;Combined with the adjustable fixing system formed by the hook surface of elastic band one, elastic band two and magic tape and the nap surface of magic tape, it is suitable for different body shapes.

The purpose of the present invention is to provide a compound having M3 PAM activity.Examples of the present invention include azabenzimidazole compounds represented by the following formula [1] and pharmaceutically acceptable salts thereof.The compounds of the present invention have M3 PAM activity. In addition, since the compounds of the present invention have M3 PAM activity, the compounds of the present invention are useful as preventive agents or therapeutic agents for urination disorders and urine collection disorders in underactive bladder, hypotonic bladder, acontractile bladder, detrusor underactivity, and neurogenic bladder.

The invention provides a non-invasive bladder pressure detection device and method based on electrical impedance. The non-invasive bladder pressure detection device comprises a waistband assembly and a pressure detection assembly. Wherein the pressure detection assembly comprises a pressure detection host and an electrode limiting piece, and the pressure detection host comprises an electrical impedance acquisition module used for acquiring electrical impedance data of the skin on the outer surface of the bladder area of a patient and a data processor installed on the surface of the electrical impedance acquisition module; the electrode limiting piece comprises a supporting piece and two electrode slice limiting pieces which are installed on the supporting piece and used for limiting the position of an electrode slice. The bladder pressure monitoring system has the advantages that the problems that an existing bladder pressure monitoring technology is high in invasiveness, complex in operation, dependent on professional places, high in cost and the like can be solved, and a neurogenic bladder patient can be helped to achieve comfortable data collection and urination time planning so as to maintain a low-pressure bladder environment; the concurrent risk is reduced, the burden of the patient is relieved, and the medical work efficiency is improved.

The invention provides a traditional Chinese medicine composition for preventing and treating neurogenic bladder urinary retention and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compounds. The traditional Chinese medicine composition is prepared from the following components: 10 to 30 parts of radix paeoniae rubra, 20 to 50 parts of poria cocos, 10 to 30 parts of cassia twig, 10 to 25 parts of cortex moutan, 8 to 15 parts of peach kernel, 8 to 20 parts of radix cyathulae, 10 to 30 parts of cowherb seed, 2 to 5 parts of amber, 10 to 20 parts of earthworm, 8 to 15 parts of pericarpium citri reticulatae, 8 to 15 parts of radix semiaquilegiae and 8 to 15 parts of fistular onion stalk. Aiming at the etiology and pathogenesis of a patient suffering from neurogenic bladder urinary retention, a prevention and treatment strategy of promoting blood circulation to promote menstruation, promoting urination and regulating qi-flowing for strengthening spleen is adopted, and the medicines are used according to a primary formula and a secondary formula, so that the compatibility relationship of the medicines used in the traditional Chinese medicine composition is closely related to the disease of neurogenic bladder urinary retention; the prepared Chinese herbal medicine compound preparation can obviously improve the urination function, is beneficial to recovery of bladder nerve functions, promotes improvement of urodynamics and improves the clinical curative effect.

The invention provides a percutaneous spinal cord electrical stimulator which comprises a switching power supply module, a power supply module, an MCU, an electrotherapy power supply module 1, an electrotherapy power supply module 2, a voltage sampling module 1, a voltage sampling module 2, a power amplifier driving module, a power amplifier current sampling module and a power amplifier voltage sampling module. According to the invention, intermediate frequency waves of 10kHz are adopted as carrier waves, so that the impedance of human skin can be reduced, the current efficiency and penetration depth of treatment are improved, meanwhile, the pricking feeling of the skin can be reduced, and the comfort is improved; however, the single carrier wave lacks a low-frequency treatment effect, so that after the low-frequency envelope signal is superposed on the carrier wave, the low-frequency envelope signal has a good curative effect on nerve regulation and muscle rehabilitation; the system has the advantages of being simple in circuit, safe, reliable, good in comfort, capable of being miniaturized and the like, and is suitable for clinical application such as spinal cord injury, stroke rehabilitation, neurogenic bladder and analgesia treatment and the like.

The application provides a functional magnetic stimulation parameter adaptive adjustment system for neurogenic bladder, and relates to the technical field of image processing. The height change rate of the filling medium is obtained according to a first scanning image and a second scanning image. The target height is determined based on the second scanning image. The basic adjustment parameter and the dynamic adjustment parameter are determined according to the height change rate and the target height. The dynamic adjustment parameter is used to control the real-time adjustment of the basic adjustment parameter. The area change rate in the dynamic adjustment parameter is calibrated based on the third height in the third scanning image at the end time in the scanning interval period. The third scanning image is taken as the current second scanning image. The above steps are repeated until the second height of the current second scanning image is the maximum structure division height. The magnetic stimulation parameter of the target person is obtained. The magnetic stimulation parameter can be adaptively adjusted according to the real-time dynamic change of the bladder filling state, so that the stimulation intensity and the filling state of the bladder are accurately matched.

This utility model relates to a drainage device for patients with neurogenic bladder, comprising a hollow catheter with a flow channel extending in a spiral direction and recessed radially towards the axis on the outer surface of the catheter. Multiple drug application holes connected to the inner lumen of the catheter are spaced apart along the extension path of the flow channel's bottom wall. The inlet end of each drug application hole is located on the inner wall of the catheter, and the outlet end is located on the bottom wall of the flow channel. The inlet end is offset distally along the axial direction of the catheter relative to the outlet end, forming a reverse inclined channel from the inlet end to the outlet end. This allows the medication injected into the catheter to diffuse along the extension direction of the flow channel after being discharged through the drug application hole. This drainage device, through the combined guiding effect of the spiral flow channel and the inclined drug application holes, allows the medication to diffuse along the spiral trajectory within the flow space formed by the flow channel and the inner wall of the urethra, reducing medication retention in local areas and lowering the risk of infection caused by medication accumulation.

The purpose of the present invention is to provide a compound having PAM M3 activity. Examples of the present invention include azabenzimidazole compounds represented by the following formula [1] and pharmaceutically acceptable salts thereof. (see Formula) [1] The compounds of the present invention have PAM M3 activity. Furthermore, since the compounds of the present invention have PAM M3 activity, the compounds of the present invention are useful as preventive or therapeutic agents for micturition disorders and urine accumulation disorders in underactive bladder, hypotonic bladder, acontractile bladder, detrusor hypoactivity, and neurogenic bladder.

The application discloses a closed-loop feedback type active rehabilitation system and method for neurogenic bladder, and particularly relates to the technical field of medical devices, aiming at the problems of low training frequency and passive participation of patients in the prior art, the system comprises: a urinary catheter, one end of which is provided with a first interface and a second interface; a perfusion circuit comprising a liquid infusion device in communication with the first interface; a urination circuit comprising a drainage device in communication with the second interface, and the urination circuit is integrated with a pressure sensor and a resistance controller; an electric stimulation module comprising a pulse generator and a body surface electrode; and a control and display unit in signal connection with the perfusion circuit, the pressure sensor, the resistance controller and the electric stimulation module respectively. The application realizes periodic filling and emptying of the bladder through closed-loop control, breaks through the physiological training frequency limit, changes passive drainage into active participation, real-time feedback and automatic operation, maximally utilizes neural plasticity, and significantly improves efficiency.

The utility model relates to a kind of anti-reflux urinary catheter device, including urinary catheter and the anti-backflow valve assembly and sealing ring of its inner cavity, anti-backflow valve assembly includes the retaining rod extending along urinary catheter axial direction, and valve piece is slidably sleeved on it;Valve piece proximal end surface is provided with inclined sealing surface, to form sealing fit with the inner side corresponding slope of sealing ring;Retaining rod is provided with the variable stiffness spring around, and proximal end is abutted on the bottom surface of valve piece far end.This utility model's urinary catheter device is combined with the nonlinear resilience of spring and the impact damping effect of limiting flange, so that valve piece can be gradually reset along axial direction, to realize dynamic sealing balance in the case of pressure mutation.This design is particularly suitable for coping with the common bladder pressure sudden rise in neurogenic bladder, ensure that the device can still effectively maintain sealing state when pressure increases suddenly, reduce the risk of urine reflux.