9 results about "Neurogenic Urinary Bladder" patented technology

The present invention provides a prophylactic or therapeutic agent for accompanying symptoms associated with diseases caused by spinal marrow or brain disorders, such as spinal marrow injury or HTLV-1-associated spinal marrow disease, which contains an RGMa inhibitor. Also provided is a prophylactic or therapeutic agent for spasmodic or neurogenic bladder, said prophylactic or therapeutic agent containing an RGMa inhibitor.

Devices and methods for evaluating and treating neurogenic bladder (NB) are disclosed. In some embodiments, a probe may include microneedles for gently puncturing the bladder detrusor tissue of a test subject. The microneedles may non-invasively collect a series of electric impedance myography (EIM) measurements to evaluate the condition of the bladder and assist in diagnosis. In some embodiments, the probe may provide information regarding the tissue's structural and biophysiological condition, in a real-time, quantitative, and objective manner. In some embodiments, the probe may assist in identifying optimal treatment (e.g., Botox or biomaterials injection) sites for NB by providing real-time results.

The present invention relates to a novel compound YJ102 for the prevention or treatment of bladder diseases, a composition for the prevention or treatment of neuropathic pain, neuroinflammation, or inflammatory skin diseases, or for the treatment of intractable neurological diseases including neurogenic bladder. The compound YJ102 of the present invention suppresses neuropathic pain caused by various factors with superior efficacy compared to conventional drugs, improves urinary dysfunction caused by spinal cord injury, restores bladder enlargement and bladder function, suppresses the development of erythema and scaling, which are major symptoms of psoriasis in animal models of psoriasis, suppresses thickening of the epidermal layer, and suppresses splenomegaly caused by psoriasis. Therefore, it can be utilized for the treatment of various intractable neurological diseases or bladder diseases.

The invention discloses a real-time pressure capacity monitoring and precise catheterization method and system for a neurogenic bladder, and belongs to the field of medical health, and the method comprises the steps: collecting bladder pressure data in real time through a wearable sensor, and carrying out filtering processing to obtain a clean pressure sequence; time sequence features are extracted, and a future pressure evolution path is predicted by adopting a long-short-term memory network; when the predicted path exceeds a safety threshold value, an intervention signal is generated, and individual difference historical data is fused to determine a personalized catheterization opportunity; and finally, outputting a catheterization prompt matched with the scene according to the activity state of the patient. The system correspondingly comprises a data acquisition module, a filtering processing module, a feature extraction module, a trend prediction module, an early warning judgment module, an opportunity determination module, a trigger sequence generation module and a reminding output module. According to the invention, continuous dynamic monitoring and accurate prediction of the bladder state are realized, individualized and scenarized urinary catheterization intervention prompts can be provided, and the safety and timeliness of neurogenic bladder management are effectively improved.

The application provides a functional magnetic stimulation parameter adaptive adjustment system for neurogenic bladder, and relates to the technical field of image processing. The height change rate of the filling medium is obtained according to a first scanning image and a second scanning image. The target height is determined based on the second scanning image. The basic adjustment parameter and the dynamic adjustment parameter are determined according to the height change rate and the target height. The dynamic adjustment parameter is used to control the real-time adjustment of the basic adjustment parameter. The area change rate in the dynamic adjustment parameter is calibrated based on the third height in the third scanning image at the end time in the scanning interval period. The third scanning image is taken as the current second scanning image. The above steps are repeated until the second height of the current second scanning image is the maximum structure division height. The magnetic stimulation parameter of the target person is obtained. The magnetic stimulation parameter can be adaptively adjusted according to the real-time dynamic change of the bladder filling state, so that the stimulation intensity and the filling state of the bladder are accurately matched.

This utility model relates to a drainage device for patients with neurogenic bladder, comprising a hollow catheter with a flow channel extending in a spiral direction and recessed radially towards the axis on the outer surface of the catheter. Multiple drug application holes connected to the inner lumen of the catheter are spaced apart along the extension path of the flow channel's bottom wall. The inlet end of each drug application hole is located on the inner wall of the catheter, and the outlet end is located on the bottom wall of the flow channel. The inlet end is offset distally along the axial direction of the catheter relative to the outlet end, forming a reverse inclined channel from the inlet end to the outlet end. This allows the medication injected into the catheter to diffuse along the extension direction of the flow channel after being discharged through the drug application hole. This drainage device, through the combined guiding effect of the spiral flow channel and the inclined drug application holes, allows the medication to diffuse along the spiral trajectory within the flow space formed by the flow channel and the inner wall of the urethra, reducing medication retention in local areas and lowering the risk of infection caused by medication accumulation.

The application discloses a closed-loop feedback type active rehabilitation system and method for neurogenic bladder, and particularly relates to the technical field of medical devices, aiming at the problems of low training frequency and passive participation of patients in the prior art, the system comprises: a urinary catheter, one end of which is provided with a first interface and a second interface; a perfusion circuit comprising a liquid infusion device in communication with the first interface; a urination circuit comprising a drainage device in communication with the second interface, and the urination circuit is integrated with a pressure sensor and a resistance controller; an electric stimulation module comprising a pulse generator and a body surface electrode; and a control and display unit in signal connection with the perfusion circuit, the pressure sensor, the resistance controller and the electric stimulation module respectively. The application realizes periodic filling and emptying of the bladder through closed-loop control, breaks through the physiological training frequency limit, changes passive drainage into active participation, real-time feedback and automatic operation, maximally utilizes neural plasticity, and significantly improves efficiency.

The utility model relates to a kind of anti-reflux urinary catheter device, including urinary catheter and the anti-backflow valve assembly and sealing ring of its inner cavity, anti-backflow valve assembly includes the retaining rod extending along urinary catheter axial direction, and valve piece is slidably sleeved on it;Valve piece proximal end surface is provided with inclined sealing surface, to form sealing fit with the inner side corresponding slope of sealing ring;Retaining rod is provided with the variable stiffness spring around, and proximal end is abutted on the bottom surface of valve piece far end.This utility model's urinary catheter device is combined with the nonlinear resilience of spring and the impact damping effect of limiting flange, so that valve piece can be gradually reset along axial direction, to realize dynamic sealing balance in the case of pressure mutation.This design is particularly suitable for coping with the common bladder pressure sudden rise in neurogenic bladder, ensure that the device can still effectively maintain sealing state when pressure increases suddenly, reduce the risk of urine reflux.