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Dragon fruit-derived polypeptide as well as application and preparation method thereof

A technology of preparations and pharmaceutical excipients, applied in the field of peptides and plant-based albumin extracted from dragon fruit, can solve problems such as easy poisoning, water pollution, and excessive heavy metal content in human food intake, and achieve inhibition of arteriosclerosis, The effect of increasing value and increasing farmers' income

Active Publication Date: 2014-12-10
CHANGZHOU ADAM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the lack of attention to the treatment and recycling of industrial wastewater and waste, various water resources have been severely polluted by heavy metals. In addition to direct drinking water poisoning, human beings are also prone to poisoning if the heavy metal content in food exceeds the standard.

Method used

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  • Dragon fruit-derived polypeptide as well as application and preparation method thereof
  • Dragon fruit-derived polypeptide as well as application and preparation method thereof
  • Dragon fruit-derived polypeptide as well as application and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Carry out in a space with an ambient temperature of 16°C. After the pitaya is peeled, the pulp is crushed with a low-temperature mixer, and water is added at a ratio of 1:1; the pitaya is peeled, and the pitaya skin is used to extract anthocyanins. The pulp of the dragon fruit is mashed, and the seeds of the dragon fruit are separated from the pulp with a strainer. The pulp that has been de-seeded is used to make pulp, and then to produce dragon fruit drinks. The seeds of dragon fruit are crushed and separated at low temperature, and the total protein is extracted by adding water.

[0027] 2. The total protein solution was diluted with 4 times the volume of acetic acid-sodium acetate buffer solution, and the pH of the protein dilution solution was adjusted to 4.5 with 0.1mol / L NaOH.

[0028] 3. Slowly add octanoic acid dropwise while stirring with an electromagnetic stirrer at room temperature (addition amount is 1L protein dilution plus 25ml), and continue stirrin...

Embodiment 2

[0038] Effects of peptides on mouse model of atherosclerosis

[0039] A mouse model of atherosclerosis was established. Forty 8-week-old male C57BL / 6J mice were randomly divided into 4 groups: Group A was the blank control group: fed with common feed; Group B was the model control group: model-making + high-fat feed feeding; Group C Drug intervention group: modeling + high-fat feed + polypeptide (10mg / kg / d); D: positive drug intervention group: modeling + high-fat feed + rosuvastatin tablets (10mg / kg / d). 12 consecutive weeks. The mice in group A were fed with common feed, and the mice in groups B, C, and D were fed with high-fat and high-cholesterol feed (containing 15% lard + 0.25% cholesterol) to accelerate the formation of atherosclerosis model. After 12 weeks, the body weight of the mice was recorded, and the effects of peptides on serum cholesterol were detected: serum total cholesterol (TC), triglyceride (tryglyeride, TG), high-density lipoprotein cholesterol (high den...

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Abstract

The invention relates to the dragon fruit reprocessing field and specifically relates to a polypeptide and a method for extracting vegetable albumin from dragon fruit. The amino acid sequence of the polypeptide is ATCRTPTTLKLGGEERRRADTTGKLAA. The invention also relates to the application of the polypeptide in preparing an anti-arteriosclerosis medicine. According to the method for extracting the vegetable albumin from the dragon fruit, the albumin extract of the dragon fruit is obtained through a new extraction process for the first time and the polypeptide is obtained by being separated from the albumin extract. The polypeptide has the function of inhibiting arteriosclerosis. Deep processing of the dragon fruit is expanded and a raw material is provided for further developing health care products or medicines.

Description

technical field [0001] The invention relates to the field of reprocessing of dragon fruit, in particular to a polypeptide and a method for extracting vegetable albumin from dragon fruit Background technique [0002] Dragon fruit is a low-energy fruit, rich in water-soluble dietary fiber, which has the effects of losing weight, lowering cholesterol, preventing constipation, and colorectal cancer. It is also rich in fiber, which can prevent constipation. Dragon fruit contains plant-based albumin, which is rarely found in general vegetables and fruits. This albumin will combine with heavy metal ions in the human body to detoxify. It is rich in antioxidant vitamin C, which can whiten the skin and prevent dark spots. In addition, the content of iron in dragon fruit is also very rich. [0003] It contains plant-based albumin and anthocyanins, which are rare in general plants, rich in vitamins and water-soluble dietary fiber. Albumin is a viscous, colloidal substance that can de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23J3/14
Inventor 叶亚东霍世元张娟全利陶露
Owner CHANGZHOU ADAM BIOTECH
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