Liquid chromatography mobile phase early warning device

Abstract

The invention discloses a liquid chromatography mobile phase early warning device. The liquid chromatography mobile phase early warning device mainly comprises a liquid chromatograph and an intelligent control system, wherein the liquid chromatograph comprises a pump, and a sample injector, a chromatographic column, a detector and a waste liquid bottle which are sequentially connected with one another through pipelines; the input end of the pump is connected with a mobile phase containing bottle; the output end of the pump is connected with the input end of the chromatographic column through a pipeline by virtue of the sample injector; the intelligent control system comprises a temperature sensor, a pressure sensor, a PLC host, a PLC module and a touch display screen; the PLC module is in plug-in connection with the PLC host; the temperature sensor and the pressure sensor are respectively arranged in the mobile phase containing bottle; an analog signal acquired by the temperature sensor and the pressure sensor is received through the PLC module, converted into a digital signal and fed into the touch display screen through the PLC host. According to the device, the operating temperature and the operating pressure of the mobile phase are monitored in real time, so that a phenomenon that air bubbles in the mobile phase escape due to temperature rise or pressure drop is avoided.

Description

technical field [0001] The invention relates to the technical field of analytical chemistry, in particular to a liquid chromatography mobile phase early warning device. Background technique [0002] Liquid chromatography mobile phase usually refers to various low boiling point solvents and aqueous solutions. Compared with gas chromatography, liquid chromatography mobile phase not only has a wider selection range, but also is a very important adjustable factor affecting separation. At present, the mobile phases of commonly used liquid chromatographs are divided into polar, non-polar, volatile, non-volatile, etc., and the solvent bottles containing the mobile phase are mostly open structures that communicate with the air. The formula structure does not have much effect on the commonly used non-volatile neutral mobile phase, but it is easy to absorb carbon dioxide in the air and affect its pH value, which is alkaline mobile phase and organic phase. There are greater limitatio...

AI Technical Summary

Problems solved by technology

This technical solution has a good sealing effect and is applicable to volatile mobile phases. However, since the deflated plastic bag is used to judge whether the mobile phase is used up, the judgment accuracy is poor, especially when the plastic bag is leaked or When the mobile phase produces bubbles, it is difficult to judge whether the mobile phase is used up, and there will be no early warning, so real-time monitoring of the mobile phase cannot be performed

[0004] In order to realize the monitoring and reminding of the mobile phase of liquid chromatography, the Chinese patent with the publication number CN 202734898 U discloses a monitoring and reminding device for the mobile phase of liquid chromatography. The device is to set a weighing module at the bottom of the flow bottle , the flow bottle is equipped with an external display device, with which the remaining volume of the mobile phase and the replacement time of the mobile phase can be clearly indicated; however, when the temperature or pressure changes and the mobile phase generates bubbles, the display device will not give a prompt or early warning , thus causing system failure and causing unnecessary economic losses

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