Method for extracting theophylline from tea leaves by using chloromethyl polystyrene resin
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A technology for chloromethyl polystyrene and resin, which is applied in the field of extracting theophylline and achieves the effects of low requirements, mild conditions and simple process flow
Inactive Publication Date: 2015-02-04
CHONGZHOU HERUI TECH
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There is no report on the preparation process of theophylline in tea
Method used
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Embodiment 1
[0026] The present invention provides a method for preparing theophylline, including the following steps:
[0027] (1) Extraction of theophylline
[0028] Take 2kg of dry theophylline, prepare 8 times the volume of the KCl solution with a mass fraction of 3.0%, and adjust the pH value of the chloride salt solution to 2. When adjusting the pH value of the KCl solution, the acid used is hydrochloric acid. 2 times, 48h each time, combine the extracts and discard the medicine residue;
[0029] (2) Enrichment of theophylline
[0030] The combined extracts were adsorbed by chloromethyl polystyrene resin column chromatography, the ratio of the volume of the macroporous adsorption resin to the weight of the dried tea medicinal materials was 1Kg:1L, and the adsorption speed was controlled at 2.0BV / h; after the adsorption, use 1.0 BV was eluted with water to remove impurities; then eluted with 2.5BV of 30% ethanol, collected the eluate, and concentrated under reduced pressure at 60℃ to obtain ...
Embodiment 2
[0035] A preparation method of theophylline monomer includes the following steps:
[0036] (1) Extraction of theophylline Take 2 kg of dry tea leaves, prepare a 10 times volume of NaCl solution with a mass fraction of 4.0%, and adjust the pH value of the chloride salt solution to 2.5. When adjusting the pH value of the chloride salt solution, The acid used is sulfuric acid, extract twice, each 48h, combine the extracts and discard the medicine residue;
[0037] (2) Enrichment of theophylline
[0038] The combined extracts are adsorbed by chloromethyl polystyrene resin column chromatography, the ratio of the volume of the macroporous adsorption resin to the weight of the dried tea is 1Kg: 2L, and the adsorption speed is controlled at 2.5BV / h; after the adsorption is completed, use 1.0BV first The water was eluted to remove impurities; then eluted with 3.0BV of 35% ethanol, collected the eluate, and concentrated under reduced pressure at 75°C to obtain an extract;
[0039] (3) Purifica...
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Abstract
The invention provides a method for extracting theophylline from tea leaves by using chloromethyl polystyrene resin. The method comprises the following steps: A, extraction of theophylline: preparing a chlorine salt solution, and soaking a tea medicinal material by using the chlorine salt solution for extraction; enrichment of theophylline: performing column chromatography and adsorption on an extracting solution by using chloromethyl polystyrene resin, performing elution after adsorption, collecting an eluent, and then performing reduced pressure concentration to obtain an extract; and C, purification: performing alumina column chromatography on the extract, then performing elution, collecting the eluent, then performing reduced pressure concentration, and performing refrigeration, crystallization, filtration and drying on a concentrated solution to obtain theophylline compounds. According to the method provided by the invention, a large amount of high-quality theophylline compounds can be obtained by virtue of four steps namely acidic chlorine salt solution extraction, macroporous adsorption resin enrichment, alumina column chromatography and crystallization. The four steps are mild in condition, high in adsorption efficiency and short in preparation cycle; and the method is simple in technological process and simple and convenient to operate, has low requirements for the technological level of operators, and is suitable for industrial popularization.
Description
technical field [0001] The invention relates to a method for extracting theophylline from tea leaves by using chloromethyl polystyrene resin, belonging to the technical field of tea deep processing. Background technique [0002] Theophylline is a methyl purine compound and an important component of tea. It can stimulate the central nervous system, dilate blood vessels, speed up blood circulation, enhance muscle contraction, and strengthen the heart. It is also a good diuretic, which can strengthen kidney function, facilitate urination, and excrete toxins and waste from the kidney as soon as possible. Therefore, tea can prevent kidney disease and stone disease. Theophylline's function is mainly to dissolve fat, and has the effect of eliminating indigestion and greasy. This is the reason why drinking tea can lose weight, and the effect is more significant. Therefore, the extraction and separation process development of high-purity theophylline is of great significance. Ther...
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