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Gentamicin sulfate composition chewable tablets and preparation method thereof

A technology of gentamicin sulfate and composition, which is applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve the effects of unique technology, improved molding, and convenient operation

Inactive Publication Date: 2015-04-08
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Starch is formed by the polymerization of glucose molecules. It is the basic auxiliary material of oral solid preparations. It is often used as a binder, diluent and disintegrating agent in chewable tablets. The starch is extracted from natural substances such as corn and cassava. It is safe, reliable, It is cheap and easy to obtain, but there is no report on the use of starch alone as an auxiliary material for the production of chewable tablets

Method used

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  • Gentamicin sulfate composition chewable tablets and preparation method thereof
  • Gentamicin sulfate composition chewable tablets and preparation method thereof
  • Gentamicin sulfate composition chewable tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription: 1000 tablets

[0029]

[0030] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 6.5, then heat to 72°C and keep for 120 minutes to make about 10% (W / V) Gelatinized cornstarch solution.

[0031] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0032] C. Mix the medicinal solution obtained in step A with the solution obtained in step B, stir thoroughly for 30 minutes, and then lower the medicinal solution to normal temperature to obtain a gelatinized corn-sucrose system medicinal solution.

[0033] D. Take by weighing 20 g of gentamicin sulfate (calculated as 1000 tabl...

Embodiment 2

[0038] Prescription: 1000 tablets

[0039]

[0040] A. Weigh 150g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 6.5, then heat to 72°C and keep for 120 minutes to make about 5-15% (W / V) gelatinized cornstarch solution.

[0041] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0042] C. Mix the medicinal solution obtained in step A with the solution obtained in step B, stir thoroughly for 30 minutes, and then lower the medicinal solution to normal temperature to obtain a gelatinized corn-sucrose system medicinal solution.

[0043] D. Take by weighing 20 g of gentamicin sulfate (calculated as 1000 t...

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Abstract

The invention provides gentamicin sulfate composition chewable tablets and a preparation method thereof, and relates to the technical field of medicine and medicine production. The gentamicin sulfate composition chewable tablets comprise gentamicin sulfate, starch and sucrose; the tablets overcome the shortcomings of common chewable tablets, and the types and amount of accessories in the gentamicin sulfate chewable tablets are reduced; and the medicine preparation has good performance, high bioavailability and good stability, is highly accepted by patients, avoids gritty feel and has an important value in clinical application.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a gentamicin sulfate composition chewable tablet and a preparation method thereof. Background technique [0002] Tablets are stable in quality and easy to take, and are the most basic and commonly used preparation form. However, for children, the elderly, and patients with dysphagia, ordinary tablets are often difficult to take, and long-term medication may even lead to psychological drug resistance. Chewable tablets can make up for this deficiency. Chewable tablets are a type of tablet that can be chewed and swallowed in the oral cavity. They are generally the same size as ordinary tablets, and can be made into special-shaped tablets of different shapes according to needs. The tablet is easy to swallow after being chewed, and the surface area of ​​the tablet increases, which can promote the dissolution and absorption of the drug in the body. For drugs ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7036A61K47/36A61K47/26A61P31/04
Inventor 李彪石金友汪金灿郝结兵吴函峰
Owner HAINAN WEI KANG PHARMA QIANSHAN
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