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Tissue chip receptor blank wax block preparation device and using method thereof

A technology for tissue chips and wax blocks, applied in the field of demolding devices and molds for tissue chips, can solve the problems of low demolding accuracy of workers, unadjustable size of wax blocks, lack of demolding devices, etc., to avoid property loss, The effect of eliminating processing technology and accurate demoulding

Active Publication Date: 2015-04-22
胡苹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] my country's utility model patent tissue chip array wax block mold publication number is 201654029U, and the public date is 2010-11-24, which discloses a tissue chip array wax block mold such as figure 1 As shown, it includes a groove-shaped array orifice plate 1' and an array column plate 2', and a number of evenly arranged array columns 3' are integrated on the array column plate 2', and the top surface of the array column 3' is arc-shaped , the bottom surface of the array hole plate 1' is provided with array holes corresponding to the array column 3', and a set of backing plates 4' are installed between the bottom surface of the array orifice plate 1' and the array column plate 2', and the backing plate 4' and the array column 3' is set vertically, the array column plate 2' is closely attached to the backing plate 4', the backing plate 4' is provided with backing plate array holes corresponding to the array column 3', and the array column 3' passes through the backing plate array hole , and enter the groove of the array orifice plate 1' through the array holes from the bottom surface of the orifice array 1', and the size of the wax block cannot be adjusted, resulting in waste of materials
[0004] However, the lack of a demoulding device leads to a time-consuming and laborious demoulding process for the workers, and the accuracy of the demoulding is not high, and the size of the wax block cannot be adjusted.

Method used

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  • Tissue chip receptor blank wax block preparation device and using method thereof
  • Tissue chip receptor blank wax block preparation device and using method thereof
  • Tissue chip receptor blank wax block preparation device and using method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Such as Figure 2-7As shown, the tissue chip acceptor blank wax block preparation apparatus of the present invention includes a tissue chip array wax block mold. The tissue chip array wax block mold includes an array column plate 3 , an array column 32 , an array hole plate 4 , and a backing plate 5 . There are multiple array columns 32, and a plurality of array columns 32 form a cuboid. The front, back, left and right sides of the cuboid form a peripheral surface, and the center of the backing plate 5 is provided with a rectangular hole, and the peripheral surface matches the rectangular hole. , so that the backing plate 5 is set on the peripheral surface of the cuboid formed by the array columns 32 . It also includes a base 11, a lifting device 12, a push column 13, a push plate 14, a push rod 15, a guide rail seat 2, a guide rail 21, a longitudinal baffle 22 and a seat push hole 23.

[0043] Such as image 3 As shown, the base 11 is fixed on the bottom plate of th...

Embodiment 2

[0055] The difference between the second embodiment and the first embodiment is that the cross-sectional shape of the guide post 33 is a rounded rectangle, and the shape of the guide hole 34 is a rounded rectangular hole matched with the guide post 33 .

[0056] The number of said push rods 15 is three, and the three push rods 15 are distributed in an isosceles triangle on the push plate 14 . The seat pushing hole 23 on the guide rail seat 2 is in clearance fit with the push rod 15 .

[0057] During use, put the array column plate 3 of the array wax block mold into the guide rail and reach the position where the longitudinal baffle 22 is limited, and the push hole 31 of the detection plate and the push hole 23 of the seat are coaxial and can be used.

[0058] Such as Figure 8 As shown, a method for preparing a medium-sized wax block with a tissue chip receptor blank block preparation instrument comprises the following steps:

[0059] A. Drop the lifting device 12 to the low...

Embodiment 3

[0065] The difference between Embodiment 3 and Embodiment 1 is that the number of push rods 15 is two, and the cross-section of the push rods 15 is a long rectangle with rounded corners. The seat pushing hole 23 on the guide rail seat 2 is in clearance fit with the push rod 15 .

[0066] Such as Figure 9 As shown, a method for preparing a small size wax block with a tissue chip receptor blank block preparation instrument comprises the following steps:

[0067] A. Drop the lifting device 12 to the lowest point;

[0068] B. Insert the left vertical board and the rear vertical board into the left groove and the rear groove respectively. The left end face of the rear riser is close to the front end face of the left riser and the middle part of the rear surface of the front riser is close to the front face. The front riser is inserted between the array columns 32. The vertical board is inserted between the array columns 32, and the rear end surface of the right vertical board i...

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PUM

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Abstract

The invention discloses a tissue chip receptor blank wax block preparation device, relates to a mould and particularly relates to a mould for the tissue chip, a de-molding device and a using method of the tissue chip receptor blank wax block preparation device. The tissue chip receptor blank wax block preparation device is relatively simple, flexible, relatively convenient to operate, convenient to de-mould and high in de-molding precision. A lifting device fixed on a base is used for jacking a pushing rod on a pushing plate; the pushing rod penetrates through a base pushing hole and a plate pushing hole for jacking an array pore plate; a guide rail base is used for fixing an array column plate through a guide rail, so that the array column plate obtains tensile force produced by gravity force of the guide rail base; the thrust force of the pushing rod and the gravity force of the guide rail base co-act for separating the mould for completing de-molding, so that inconvenience caused by manual de-molding is avoided; meanwhile, the direction of the thrust force and the direction of the tensile force are parallel, so that the de-molding is accurate, the property loss caused by manual de-molding errors is avoided, and the wax block is adjustable in size through a vertical plate.

Description

technical field [0001] The invention relates to a mould, in particular to a mould, a demoulding device and a use method thereof for tissue chips. Background technique [0002] As we all know, in DNA chip technology, tissue chips are also called tissue microarrays. Biochip, referred to as tissue chip. The solid phase carrier is the acceptor blank wax block. With the development and extension of DNA chip technology, this technology has the advantages of high output, small experimental error, time saving, labor saving and cost saving, and can be used in scientific research, teaching, biological agent testing, quality control and standardization and other fields . Therefore, it is a very popular technical method at present. [0003] my country's utility model patent tissue chip array wax block mold publication number is 201654029U, and the public date is 2010-11-24, which discloses a tissue chip array wax block mold such as figure 1 As shown, it includes a groove-shaped arr...

Claims

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Application Information

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IPC IPC(8): G01N33/48
Inventor 胡苹马剑宁
Owner 胡苹
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