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Application of sodium butyrate for preventing noise-induced hearing loss

A technology for hearing impairment and sodium butyrate, applied in the field of biomedicine, can solve the problems of no sodium butyrate, prevention of noise-induced deafness without sodium butyrate, etc., achieve reduction of evoked potential threshold shift, good research and application prospects, The effect of preventing noise-induced deafness and cannon-shock deafness

Active Publication Date: 2015-04-29
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0008] However, there has been no report on the activity of sodium butyrate in preventing noise-induced hearing loss, nor has there been any report on the prevention of noise-induced deafness by sodium butyrate

Method used

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  • Application of sodium butyrate for preventing noise-induced hearing loss

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Embodiment Construction

[0028] The present invention provides a new application of sodium butyrate (its structural formula is shown in formula (1)), i.e. the application of sodium butyrate in the prevention of noise-induced hearing loss, wherein said noise-induced hearing loss includes noise-induced deafness and cannon-shock deafness.

[0029]

[0030] The sodium butyrate described in the present invention is purchased from the market and purchased from the American Chemical Abstracts Service (CAS) with an identification code of CAS NO.: 156-54-7.

[0031] The sodium butyrate of the present invention can be mixed with pharmaceutically acceptable auxiliary materials when preventing noise-induced hearing loss, and prepared into any pharmaceutical preparation suitable for clinical use according to the conventional pharmaceutical preparation process, such as capsules, Tablets, pills, granules, oral liquid preparations, etc.

[0032] The pharmaceutically acceptable auxiliary materials include pharmace...

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Abstract

The invention provides an application of sodium butyrate for preventing noise-induced hearing loss, and belongs to the technical field of biological medicine. According to the application of sodium butyrate for preventing noise-induced hearing loss, in the noise-induced hearing loss experiment of mice models, sodium butyrate can reduce the auditory brainstem response threshold shift after noise exposure, increase the survival rate of cochlear hair cells after noise exposure, has excellent noise-induced hearing loss preventing effect on noises at multiple frequencies, especially has excellent preventative effect on noise-induced hearing loss, explosive hearing loss and other diseases, can be used for preparing drugs and / or healthcare products for preventing noise-induced hearing loss, has good research and application prospects, and can fill in the gap of drugs for preventing noise-induced hearing loss at present.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a new application of sodium butyrate, in particular to the application of sodium butyrate in preventing noise-induced hearing loss. Background technique [0002] Noise-induced hearing loss refers to progressive sensorineural deafness caused by prolonged exposure to high-intensity noise environments. Noise-induced deafness is a cumulative disease that generally goes through four stages: auditory adaptation, hearing fatigue, early noise-induced deafness, and noise-induced deafness. The early clinical manifestations are an increase in the 4KHz hearing threshold. If it continues to develop, high-frequency hearing loss will occur, and gradually develop to the low-frequency band, and there will be general hearing loss from 500Hz to 8KHz, accompanied by persistent high-pitched tinnitus. [0003] There are two ways to prevent noise-induced deafness, one is to avoid noise exposure, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61P27/16A23L1/30A23L33/10
CPCA61K31/19
Inventor 陈福权邱建华王洁温立婷米文娟
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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