Gel preparation used for tumor in-situ treatment and preparation method

A gel preparation, in-situ technology, applied in antitumor drugs, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of poor drug targeting, poor drug targeting, toxic and side effects, etc. Anti-tumor effect, obvious effect, the effect of reducing systemic side effects

Active Publication Date: 2015-06-24
THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many chemotherapeutic drugs, such as paclitaxel and cisplatin, have poor drug targeting. The traditional infusion route often produces huge toxic and side effects due to poor drug targeting, which makes it difficult for the drug to play a role in the local tumor.

Method used

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  • Gel preparation used for tumor in-situ treatment and preparation method
  • Gel preparation used for tumor in-situ treatment and preparation method
  • Gel preparation used for tumor in-situ treatment and preparation method

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Embodiment Construction

[0022] In order to more clearly understand the purpose, technical solutions and beneficial effects of the present invention, the present invention will be further described below in conjunction with specific examples, but the protection scope of the present invention is not limited to the following examples.

[0023] 1. Experimental materials:

[0024] 1. Experimental animals: healthy female nude mice, 3-4 weeks old, weighing 18-24g, purchased from Chongqing Tengxin Pharmaceutical Technology Co., Ltd. (certificate number of experimental branches: SCXK (Beijing) 2012-0006), under SPF conditions Raised in separate cages, free access to food and water.

[0025] 2. Cell line: A549 lung cancer cell line (provided by the Central Laboratory of the Affiliated Hospital of Luzhou Medical College, and kept in the Oncology Laboratory of the Affiliated Hospital of Luzhou Medical College).

[0026] 3. Main reagents:

[0027] ε-caprolactone (ε-CL): purchased from Alfa Aesar, USA.

[0028]...

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Abstract

The invention discloses gel preparation used for tumor in-situ treatment and a preparation method of the gel preparation. The gel preparation comprises taxol micella, cis-platinum, thermos-sensitive hydrogel and normal saline in the weight ratio of (100-250): (4-20): (2000-4000): (8000-6000), wherein the thermos-sensitive hydrogel is block polymer polyethylene glycol-polycaprolactone-polyethylene glycol. The gel preparation is used for local in-situ treatment of tumors, targeting of cis-platinum and taxol micella drugs can be improved, toxic and side effects are reduced, the difficulty of fixed-point application and in-situ local treatment of deep cancer tissue of cancer patients is solved and durable curative effect is achieved. In addition, the gel preparation has dual release effect, cis-platinum and taxol micella can be loaded at the same time, cell cycle-specific agent and non-specific agent are matched to achieve synergic effect and killing effect of the tumor tissue is improved.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for treating tumors, in particular to a gel pharmaceutical preparation for in situ and local treatment of tumors. Background technique [0002] In recent years, the morbidity and mortality of malignant tumors have increased year by year, seriously threatening human health. For the treatment of tumors, there are mainly surgical treatment, chemotherapy, radiotherapy, drug therapy, etc. Among various treatment methods, chemotherapy is still a common method for treating many tumors. However, many chemotherapeutic drugs, such as paclitaxel and cisplatin, have poor drug targeting. The traditional infusion route often produces huge toxic and side effects due to poor drug targeting, which makes it difficult for the drug to play a role in the local tumor. . Contents of the invention [0003] The purpose of the present invention is to address the deficiencies of the above-mentioned prior art, to provide a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K33/24A61K31/337A61P35/00
Inventor 吴敬波傅少志邹晓晏
Owner THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIV
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