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Screening reagent box for intractable epilepsy

A technology for refractory epilepsy and kits, which can be used in the determination/examination of microorganisms, biochemical equipment and methods, etc., can solve problems such as affecting daily life, uncontrollable seizures, etc., and achieve good clinical application prospects.

Active Publication Date: 2015-07-08
SICHUAN CREDIT PHARMA
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Problems solved by technology

[0002] Refractory epilepsy, also known as intractable epilepsy, usually refers to no progressive disease or space-occupying lesions of the central nervous system, but clinically protracted, after more than 2 years of regular antiepileptic treatment, trial of main antiepileptic drugs alone or in combination, reaching Refractory epilepsy can only be determined when the patient can tolerate the maximum dose and the blood drug concentration reaches the effective range, but the seizures cannot be controlled and daily life is affected.

Method used

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  • Screening reagent box for intractable epilepsy

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Experimental program
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Effect test

Embodiment 1

[0019] Example 1 The relationship between the expression level of microRNA-153 and intractable epilepsy

[0020] 1. Experimental method

[0021] 1. Sample collection and RNA extraction

[0022] Basic information of cases and controls:

[0023] Basic Information normal people patients with refractory epilepsy number of people 80 80 average age 28 24.1 male ratio 48 / 80 48 / 80

[0024] Diagnostic criteria for patients with intractable epilepsy: After the patient has correctly used 2 or more antiepileptic drugs (with sufficient course and dose of treatment), the epilepsy is still uncontrollable (i.e., seizure-free is less than 3 times the amount of treatment). longest previous seizure interval or seizure-free period of less than 12 months).

[0025] RNA extraction: 5mL of peripheral blood was collected, 5mL of fresh blood samples were left at room temperature for 40 minutes, and centrifuged at 1800 rpm for 20 minutes to obtain serum. Take 1...

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Abstract

The invention discloses a screening reagent box for intractable epilepsy. The screening reagent box for the intractable epilepsy comprises an optional reagent used for detecting the expression level of micro RNA-153. The invention further discloses an application of the optional reagent used for detecting the expression level of the micro RNA-153 in preparing a reagent used for screening the intractable epilepsy. According to the reagent box, the expression level of the micro RNA-153 is detected, the risk of suffering from the intractable epilepsy for crowds to be examined can be judged, the reagent box can be used for auxiliary diagnosis of clinical intractable epilepsy, an effective base is provided for a patient to take relevant treatment measures or decisions, and a good clinical application prospect is achieved.

Description

technical field [0001] The invention relates to a screening kit for refractory epilepsy. Background technique [0002] Intractable epilepsy, also known as intractable epilepsy, usually refers to no progressive disease or space-occupying lesions of the central nervous system, but clinically protracted, after more than 2 years of regular antiepileptic treatment, trial of main antiepileptic drugs alone or in combination, reaching Refractory epilepsy can only be determined when the patient can tolerate the maximum dose, the blood drug concentration reaches the effective range, and the seizures cannot be controlled and daily life is affected. Refractory epilepsy accounts for about 20% to 30% of epilepsy patients. [0003] There are many causes of intractable epilepsy, most of which have brain lesions, such as hippocampal sclerosis, traumatic brain injury, tumor, tuberous sclerosis, and congenital dysplasia, etc. The influencing factors of intractable epilepsy include: ① Onset wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6883C12Q2600/158C12Q2600/178
Inventor 陈蕾周东
Owner SICHUAN CREDIT PHARMA
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