Application of selenium enriched yeast in control of Alzheimer disease

Abstract

The invention discloses application of selenium enriched yeast in control of Alzheimer disease (AD) and an experiment of the selenium enriched yeast in treatment of three genetically modified AD mice, the experiment method of the selenium enriched yeast is as follows: every gram of mouse feed is added with 4-6 grams of selenium enriched yeast, each mouse is fed with 4 grams of the se-enriched yeast-containing feed per day, multiaspect and multichannel intensive study on the effect of the selenium enriched yeast on treatment of the three genetically modified AD mice can be performed so as to provide effective data for AD treatment drug study; the selenium enriched yeast shows excellent properties of reduction of excessive tau protein phosphorylation, significant reduction of insoluble tau protein, improvement of neuronal synaptophysin and PSD95 protein level and recovery of neuronal synapse, and selenium in the selenium enriched yeast has high absorption rate, strong biological activity, less environmental pollution and the like, and is very safe, so that the selenium enriched yeas can be used for treatment of Alzheimer disease.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of selenium yeast in the prevention and treatment of Alzheimer's disease. Background technique [0002] Research on the pathogenesis, process and evaluation of AD therapeutic drugs in triple-transgenic AD mice has always been a hot topic of research by scholars. In the prior art, the method of feeding selenomethionine is generally used to study the therapeutic effect of selenium on triple-transgenic AD mice, but selenium The therapeutic effect of methionine on mice is not satisfactory, and selenomethionine is expensive, which leads to an increase in experimental costs. [0003] Selenium yeast is a type of yeast enriched in selenium, and its selenium mainly exists in the form of selenomethionine and selenocysteine; it has good antioxidant, anti-aging and anti-tumor effects like traditional selenium-enriched drugs , and compared with the traditional ones, it has b...

AI Technical Summary

Problems solved by technology

[0002] Research on the pathogenesis, process and evaluation of AD therapeutic drugs in triple-transgenic AD mice has always been a hot topic of research by scholars. In the prior art, the method of feeding selenomethionine is generally used to study the therapeutic effect of selenium on triple-transgenic AD mice, but selenium The therapeutic effect of methionine on mice is not satisfactory, and the price of selenomethionine is expensive, which leads to the increase of experimental costs

Images