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Chinese herbal compound composition with antineoplastic activity as well as preparation method and application thereof

A technology of anti-tumor activity and composition, which is applied in the directions of anti-tumor drugs, drug combinations, and medical preparations containing active ingredients, etc. Reasonable and high content of active ingredients

Active Publication Date: 2015-08-26
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

However, the currently reported antineoplastic drugs have a large dosage and many impurities.

Method used

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  • Chinese herbal compound composition with antineoplastic activity as well as preparation method and application thereof
  • Chinese herbal compound composition with antineoplastic activity as well as preparation method and application thereof
  • Chinese herbal compound composition with antineoplastic activity as well as preparation method and application thereof

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preparation example Construction

[0036] 2. the preparation method of the Chinese medicine compound composition with antitumor activity of the present invention, it may further comprise the steps:

[0037] (1) Take 10 grams of Zedoary Curcuma in parts by weight, add 12 times the amount of water of Curcuma Curcuma medicinal material, extract by steam distillation for 2 hours, and collect volatile oil;

[0038] (2) Take 12 grams of Radix Pseudostellariae in parts by weight, 10 grams of Ophiopogon japonicus, 20 grams of Hedyotis diffusa, 20 grams of Scutellaria barbata, 15 grams of Shanzi mushroom, and add the zedoary dregs after steam distillation in step (1) , add 10 times the volume of ethanol of the total medicinal material weight, reflux or continuous reflux extraction twice, each time for 3 hours, combine the extracts, concentrate under reduced pressure at 50-80 degrees Celsius, and get the concentrate on a macroporous adsorption resin column, first use water eluting, and then sequentially eluting with etha...

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Abstract

The invention discloses Chinese herbal compound composition with antineoplastic activity as well as a preparation method and an application thereof. The Chinese herbal compound composition is prepared from 12-36 parts of heterophylly falsestarwort roots, 10-30 parts of radix ophiopogonis, 20-60 parts of hedyotis diffusa, 20-60 parts of barbed skullcap herb, 15-45 parts of Indian iphigenia bulb and 10-30 parts of rhizoma curcumae. A pharmacology experiment and a clinical experiment indicate that the Chinese herbal compound composition with the antineoplastic activity is scientific and reasonable in matching and has efficacy of resisting cancer, removing toxicity, reducing phlegm, removing stasis and tonifying qi and yin, has a strong killing function on malignant tumor cells and is wide in application range; the content of cAMP (cyclic adenosine monophosphate) in a body can be adjusted, TNF (tumor necrosis factor) generation is accelerated, the immunity of a tumor patient is improved, the lifetime is prolonged, the safety is high, and the toxic and side effects are low. According to the preparation method, the quality is stable, the content of effective extracted ingredients is high, the operatability is high, and the Chinese herbal compound composition is suitable for industrial mass production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a compound traditional Chinese medicine composition with anti-tumor activity and its preparation method and application. Background technique [0002] Tumor has become the number one killer threatening human survival in the 21st century, with an average of more than 6 million people dying of various tumor diseases every year. China is one of the countries with high incidence of cancer in the world, and it shows a rapid growth trend every year. Clinically, the current drugs for treating tumors mainly include chemical drugs. However, due to the high toxicity of chemotherapy drugs, they can not selectively kill white blood cells, lymphocytes and other human immune cells while killing tumor cells. As a result, patients often suffer from autoimmune diseases. Complicated infection due to low ability, severe adverse reactions in patients, long course of treatment, high cost, and great ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00
Inventor 程海波周仲瑛沈卫星李柳孙东东徐长亮谭佳妮沈政洁吴东东
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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