Traditional Chinese medicine preparation for treating perimenopause type metrorrhagia and preparing method of traditional Chinese medicine preparation

A technology for traditional Chinese medicine preparations and uterine bleeding, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, and can solve problems such as inconsistent diagnosis and efficacy evaluation standards, and irregular TCM syndrome differentiation and classification.

Inactive Publication Date: 2015-09-23
QINGDAO HENGBO INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are still non-standard types of syndrome differentiation in traditional Chinese medicine, and the standards for diagnosis and curative effect evaluation are not uniform.

Method used

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  • Traditional Chinese medicine preparation for treating perimenopause type metrorrhagia and preparing method of traditional Chinese medicine preparation
  • Traditional Chinese medicine preparation for treating perimenopause type metrorrhagia and preparing method of traditional Chinese medicine preparation
  • Traditional Chinese medicine preparation for treating perimenopause type metrorrhagia and preparing method of traditional Chinese medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 3

[0079] 2.1. Tested substance: Name: Pill of the present invention (obtained by the method of Example 3)

[0080] 2.2. Experimental animals: Class I big-eared white rabbits, 10, female, weighing 2.1-2.3 kg; provided by the Experimental Animal Center of the Department of Biology, Qingdao University School of Medicine;

[0081] 2.3. Test method:

[0082] 10 healthy rabbits with intact skin were selected, and 24 hours before the test, the hair on both sides of the back spine was cut off, and the hair removal area was about 4 cm × 4 cm on the left and right sides. During the test, take 0.2 ml of the test substance and apply it to a two-layer gauze of 2.5 cm × 2.5 cm, apply it to the surface of one side of the dehaired skin, cover it with oil paper, and fix it with adhesive tape. The skin on the other side served as a blank control. After 4 hours of sealing, the covering was removed, and the residual test substance was washed with warm water. The skin reaction at the application s...

Embodiment 4

[0091] Example 4: Skin Allergy Test Results

[0092] The tablet of the present invention was used to conduct induction and challenge contact tests, and the experimental mice were treated after 24 hours and 48 hours, and no skin erythema and edema were found, and there was no difference with the negative control group. The results showed that the tablet had nearly zero skin reaction intensity, that is, no skin allergy.

Embodiment 5

[0093] Example 5: Long-term toxicity test data

[0094]1. Experimental method

[0095] The guinea pigs were randomly divided into 4 groups of 15 animals each. Apply the depilatory agent evenly on both sides of the guinea pig's back spine so that the hair removal area is about 40 square centimeters. Wash the depilatory agent, after 24 hours of treatment, each group of guinea pigs is coated with 0.2, 0.4 and 0.8 ml of the suppository solution of the present invention, respectively, containing 92, 184 and 368 mg of crude drugs, and another group is coated with 0.8 ml of solvent twice a day for 30 consecutive days. The general condition of the guinea pigs was treated. After the experiment, the animals were sacrificed for hematological, blood biochemical and pathological examinations.

[0096] 2. Results

[0097] There were no local skin edema, congestion, erythema, bleeding spots and ulcers in the hair removal area of ​​the trunk of the guinea pigs in the above three groups. T...

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PUM

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Abstract

The invention provides a traditional Chinese medicine preparation for treating perimenopause type dysfunctional metrorrhagia. The traditional Chinese medicine preparation comprises, by weight, 10-20 parts of angelica sinensis, 10-20 parts of radix paeoniae alba, 10-20 parts of raspberry, 10-20 parts of astragalus membranaceus, 10-20 parts of herba epimedii, 10-20 parts of semen cuscutae, 10-20 parts of albizia flower, 10-20 parts of radix bupleuri, 10-20 parts of calcined oyster shell, 10-20 parts of corydalis tuber, 10-20 parts of leonurus, 10-20 parts of carbonized hair, 10-20 parts of codonopsis pilosula, 10-20 parts of trogopterus dung, 10-20 parts of poria cocos, 10-20 parts of rehmannia glutinosa, 10-20 parts of cyperus rotundus, 10-20 parts of glossy privet fruit, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of hairyvein agrimony, 10-20 parts of fried sanguisorba officinalis, 10-20 parts of caulis spatholobi and 10-20 parts of eclipta alba. The traditional Chinese medicine preparation is in accordance with the principle of treating both the manifestation and the root cause of the traditional Chinese medicine, the traditional Chinese medicine preparation deeply enters the focus to carry out treatment, on one hand, a large amount of estrogen is supplanted, blood is stopped and restrained, bleeding is stopped or relieved, and thus the dysfunctional metrorrhagia is put to an end from now on.

Description

technical field [0001] The invention relates to traditional Chinese medicines containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine preparation for treating perimenopausal dysfunctional uterine bleeding and a preparation method thereof. Background technique [0002] Perimenopause is the period that begins in a woman around age 40 and ends within 12 months of menopause. During this period, the ovarian function of women gradually declines until it disappears, which is a period of normal physiological changes. Perimenopause is a normal physiological change, and most women do not experience any discomfort, although some do. The main manifestations are: 1. Menstrual changes: Most women's menstrual changes start around 40 years old, and the average age of menopause is 49.5 years old. A small number of women have functional uterine bleeding and even severe anemia. 2. Changes in the urogenital tract: the reproductive organ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61P15/00A61P7/04A61K35/618A61K35/24A61K35/36A61K9/20
Inventor 赵玉妹
Owner QINGDAO HENGBO INSTR
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