Traditional Chinese medicine composition and preparation method, application and preparation thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its preparation, can solve the problems of no significant improvement in the overall survival rate of patients, large toxic and side effects, and unsatisfactory effects, and achieve scientific and reasonable preparation methods, clear pharmacological effects, and broad The effect of applying the foreground

Active Publication Date: 2015-11-18
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Western medicine uses glucocorticoids, interferon, pirfenidone and other drugs in clinical treatment, the effect is not ideal, and the toxicity and side effects are large, and the overall survival rate of patients has not been significantly improved.

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  • Traditional Chinese medicine composition and preparation method, application and preparation thereof
  • Traditional Chinese medicine composition and preparation method, application and preparation thereof

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preparation example Construction

[0028] The preparation method of Chinese medicine composition of the present invention comprises the steps:

[0029] a. Dengtai leaves and Aconitum yunnanensis are crushed through a 10-mesh sieve, and acetic acid-ethanol-water mixed solvent with a mass ratio of 0.1~0.5:15~20:79.5~84.9 is added in an amount 2-3 times the weight of the medicinal materials, sealed and left to soak After 8-12 hours, transfer to a percolator, extract by percolation with ethanol with a mass concentration of 30-70% of 10-12 times the weight of the material for 32-36 hours, collect the percolation extract, and filter to obtain filtrate A;

[0030] b. Panax notoginseng, Astragalus membranaceus and Chinese angelica were crushed through a 50-mesh sieve, extracted three times with ethanol with a mass concentration of 60-90%, and filtered the extract to obtain filtrate B;

[0031] c. Combine filtrate A and filtrate B, and vacuum spray dry at 40-60°C to form a powder.

[0032] In step b, for the first extr...

Embodiment 1

[0036] The preparation of embodiment 1 Chinese medicine composition 1

[0037] 1. Origin and place of origin of medicinal materials

[0038] Lampstand leaf: the dry leaf of the Apocynaceae plant Lampstand tree. Harvested in Pu'er, Yunnan Province on August 21, 2010, the original plant was identified as Apocynaceae by senior engineer Zhou Rongguang from Kunming Pharmaceutical Group Research Institute.

[0039] Panax notoginseng: It is the dried root of Panax notoginseng of the Araliaceae genus Panax, produced in Wenshan, Yunnan, and provided by Yixintang Chinese Herbal Medicine Co., Ltd. of Yunnan Province.

[0040] Aconitum yunnanensis: it is the dry root tuber of Aconitum diannanensis of Ranunculaceae plant. Harvested in Mengzi, Yunnan Province on November 8, 2010, the original plant was identified as Aconitum yunnanensis, a plant of the family Ranunculaceae, by Zhou Rongguang, a senior engineer at the Pharmaceutical Research Institute of Kunming Pharmaceutical Group.

[004...

Embodiment 2

[0049] The preparation of embodiment 2 Chinese medicine composition 2

[0050] 1. Origin and place of origin of medicinal materials

[0051] With embodiment 1.

[0052] 2. Prescription

[0053] 100 parts of Dengtai Leaf, 5 parts of Panax notoginseng, 15 parts of Diancaowu, 3 parts of Astragalus membranaceus, 30 parts of Angelica sinensis.

[0054] 3. Preparation method:

[0055] Step 1): Weigh Dengtai leaves and Aconitum yunnanensis according to the prescription amount, crush them through a 10-mesh sieve, add acetic acid-ethanol-water mixed solvent with a mass ratio of 0.5:20:79.5, which is twice the weight of the medicinal materials, and keep it in a closed place for soaking After 12 hours, put it into a percolator, extract by percolation with 30% ethanol with a mass concentration of 12 times the weight of the medicinal material for 36 hours, collect the percolation extract, and filter to obtain filtrate A for subsequent use;

[0056] Step 2): Weigh Panax notoginseng, Rad...

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Abstract

The invention discloses a traditional Chinese medicine composition and a preparation method, application and preparation thereof. The traditional Chinese medicine composition comprises, by weight, 10-100 parts of common alstonia leaves, 5-50 parts of pseudo-ginseng, 2-15 parts of Yunnan radix aconiti agrestis, 3-30 parts of astragalus membranaceus and 3-30 parts of angelica sinensis. Pharmacological researches show that the traditional Chinese medicine composition can remarkably relieve the pulmonary alveolitis and pulmonary fibrosis by bleomycin in rats and lower pulmonary fibrosis rat pulmonary coefficients and HYP, NO and MDA levels. The raw materials are easy to obtain, the preparation method is scientific, the pharmacologic action and mechanism are clear, the good effect of treating both symptoms and root causes of pulmonary fibrosis is achieved, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition and a preparation method, application and preparation thereof. Background technique [0002] Pulmonary fibrosis (PF) is a lesion characterized by proliferation of pulmonary fibroblasts and accumulation of ECM. Its early pathological features are diffuse alveolitis and destruction of alveolar structure, followed by excessive deposition of extracellular matrix, and then progresses to diffuse Pulmonary interstitial fibrosis eventually leads to respiratory failure and death of the patient. Many chronic lung diseases, including asthma, chronic bronchitis, bronchiectasis, COPD, tuberculosis, lung cancer, pneumonia, etc., are accompanied by pathological changes of pulmonary fibrosis. In addition to lung diseases, dust, smog, and chemical drugs are also the main causes of pulmonary fibrosis. In recent years, wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61P11/00
Inventor 周荣光杨兆祥赵加强
Owner KPC PHARM INC
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