Novel skeleton alkaloid compound and extraction separation method thereof

A separation method and technology of alkaloids, applied in the direction of active ingredients of heterocyclic compounds, drug combination, organic chemistry, etc., can solve the problems of weak pharmacological activity and so on

Active Publication Date: 2015-11-25
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

But the separation and the pharmacological activity research of the new framework compound of purslane in the application have not been reported, and the chemical constituent majority that ...

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  • Novel skeleton alkaloid compound and extraction separation method thereof
  • Novel skeleton alkaloid compound and extraction separation method thereof
  • Novel skeleton alkaloid compound and extraction separation method thereof

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Embodiment Construction

[0027] The invention provides a new skeleton alkaloid compound, the molecular formula is C 18 h 26 N 2 O. The chemical structural formula is as follows.

[0028]

[0029] The new skeleton alkaloid compound is named Oleracimine according to the structure, and Table 1 is the NMR data of the new skeleton alkaloid compound: 1 H-NMR with 13 C-NMR in CDCl 3 middle. Among them, "-" means that =NH is connected to C169.4 above.

[0030] Table 1: NMR data of new framework alkaloid compounds.

[0031] serial number δ C Types of δ H 2 46.8 CH 2 a: 1.47 d (J=13.5); b: 2.02 d (J=13.5) 3 38.9 C

4 50.6 C

5 52.3 CH 2 a: 2.28 d (J=15.3); b: 2.56 d (J=15.3) 6 65.7 C

7 206.2 C

8 121.3 C

9 141.0 C

10 143.5 C

11 110.7 C

12 169.4 C

- =NH 4.07 s 13 28.6 CH 3 1.34 s 14 32.5 CH 3 1.29 s 15 29.1 CH 3 1.30 s 16 27.4 CH 3 1...

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Abstract

The invention discloses a novel skeleton alkaloid compound. The novel skeleton alkaloid compound has a molecular formula of C18H26N2O, is named as Oleracimine and is shown in the chemical structural formula (I). The invention provides an extraction separation method of the novel skeleton alkaloid compound. The extraction separation method orderly comprises water decoction extraction, macroporous adsorption resin extraction, ethyl acetate extraction, silica gel column chromatography, ODS medium-pressure column treatment and Sephadex LH-20 treatment. The extraction separation method realizes simple and fast extraction separation of the novel skeleton alkaloid compound with a unique skeleton. The novel skeleton alkaloid compound has the effect of easing pain and can be used for preparation of pain easing drugs. The novel skeleton alkaloid compound is shown in the formula (I).

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new skeleton alkaloid compound in purslane medicinal material and an extraction and separation method thereof. Background technique [0002] purslane( Portulacaoleracea L. ) is a plant of the family Portulaca oleracea, which is used for toxic heat and bloody dysentery, carbuncle and furuncle, eczema, erysipelas, snake bites, blood in the stool, hemorrhoids, metrorrhagia, etc. The 2010 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of purslane is used as medicine, which has the effects of clearing away heat and detoxification, cooling blood and stopping bleeding, and stopping dysentery; modern pharmacological studies have shown that purslane has anti-inflammatory, pain-relieving, antibacterial and antiviral properties. , lowering blood pressure, blood lipids, anti-oxidation, anti-cance...

Claims

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Application Information

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IPC IPC(8): C07D487/08A61K31/55A61P29/00
CPCC07D487/08
Inventor 英锡相康廷国英哲铭张文洁艾军军
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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