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Kit for tuberculosis detection

A kit, technology for tuberculosis, applied in the field of kits for detecting tuberculosis

Active Publication Date: 2015-11-25
广东省结核病控制中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not yet been determined which microRNAs have a clear correlation with TB and can be used for the diagnosis or treatment evaluation of TB

Method used

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  • Kit for tuberculosis detection
  • Kit for tuberculosis detection
  • Kit for tuberculosis detection

Examples

Experimental program
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Effect test

Embodiment 1

[0024] sample: 50 serums from healthy people, 50 serums from patients with tuberculosis latent infection, 50 serums from patients with active tuberculosis, and 50 serums from cured tuberculosis patients;

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PUM

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Abstract

The invention discloses microRNA biomarkers related to tuberculosis, and particularly provides a kit for tuberculosis detection. The biomarkers include microRNA (ribonucleic acid) 451a, microRNA542, microRNA125b, microRNA146a, microRNA29c, microRNA365, microRNA889, microRNA335 and microRNA342. Quantitative detection of the microRNA biomarkers can be achieved according to technologies such as nucleic acid chips, qPCR (quantitative polymerase chain reaction) or sequencing, so that the kit can be used for clinically auxiliary tuberculosis diagnosis or therapeutic outcome evaluation, sensitivity and specificity of tuberculosis diagnosis are improved, and the new basis is provided for clinical treatment evaluation.

Description

technical field [0001] The present invention relates to the detection and application of microRNA. More specifically, the present invention relates to the role of microRNA451a, microRNA542, microRNA125b, microRNA146a, microRNA29c, microRNA365, microRNA889, microRNA335, and microRNA342 in the diagnosis and treatment evaluation of tuberculosis. Background technique [0002] Tuberculosis is one of the most serious infectious diseases in the world, posing a major threat to the health of all human beings. However, effective diagnostic techniques are currently lacking. The gold standard for tuberculosis diagnosis - tuberculosis culture takes 2-6 weeks, and the detection rate is only about 30%; The detection rate is less than 50%. Nucleic acid detection (GeneXpert) is convenient and fast, but it has low sensitivity and high cost for bacteria-negative patients; interferon release detection (IGRA) is sensitive, but the operation is complicated and expensive, and it cannot It is div...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12Q1/06C40B40/06
CPCC12Q1/689C12Q2600/178C40B40/06
Inventor 周琳陈亮陈涛钟球郭卉欣李海成陈瑜晖廖庆华陈珣珣舒杨周杰王威
Owner 广东省结核病控制中心
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