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Thermophoresis coupling subparticle sorter

A submicron particle and sorter technology, applied in the field of microfluidic systems, can solve the problems of poor sorting efficiency, low sorting precision, and difficulty in adapting to submicron particle sorting, so as to improve sorting precision and efficiency , is conducive to the effect of pressure balance

Inactive Publication Date: 2015-12-16
HANGZHOU DIANZI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the fact that the current inertial sorter is difficult to adapt to the sorting of submicron particles, and there are also shortcomings such as poor sorting efficiency and low sorting accuracy, in order to strengthen the cross-streamline effect of submicron particles, the effect of thermophoretic migration of coupled particles on particle sorting is studied. very meaningful

Method used

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Examples

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Effect test

Embodiment 1

[0026] Example 1, the number of sorting stages is three, assuming that an aqueous solution containing particles of 0.1, 0.5, and 1.0 microns is introduced at the inlet 1, and the particle density is 1050kg / m 3 , the inlet speed is 10mm / s, after entering the sorting channel with a height of 200 microns, the separation is carried out, the temperature difference between the upper and lower walls is controlled at 10 degrees, and the particles of 0.1, 0.5 and 1.0 microns start at 2~3 mm downstream of the sorting channel. Focus on 82, 63, and 30 microns above the centerline of the sorting channel, and export at exit 2, exit 3, and exit 4, respectively.

Embodiment 2

[0027] Example 2, the number of sorting stages is three, assuming that the inlet 1 is introduced into an aqueous solution containing particles of 0.1, 0.5, and 1.0 microns, and the particle density is 1050kg / m 3 , the inlet speed is 10mm / s, and sorting is carried out after entering the sorting channel with a height of 200 microns. When the temperature difference between the upper and lower walls is controlled at 2 degrees, the particles of 0.1, 0.5, and 1.0 microns are respectively focused on the center line of the sorting channel 62 , 36, and -30 microns are exported at outlet 2, outlet 3 and outlet 5, respectively.

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Abstract

The invention belongs to the technical field of microcontrol systems, and particularly relates to a thermophoresis coupling subparticle sorter. The thermophoresis coupling subparticle sorter is formed by bonding a substrate I and a substrate II, wherein an inlet for introducing liquid containing different subparticles is formed in the substrate I; an outlet for exporting the sorted subparticles is also formed in the substrate I; a sorting channel is formed in the substrate II; one end of the sorting channel is connected with the inlet of the substrate I, and the other end of the sorting channel is connected with the outlet in the substrate I; the sorting channel comprises an upper wall surface and a lower wall surface; an electrifiable heating chip is arranged on the lower wall surface for driving the subparticles to generate thermophoresis motion. The invention provides the subparticle sorter which realizes sorting according to the particle size, makes use of a thermophoresis coupling technology and is high in sorting efficiency and high in precision; the preparation process is simple, and the fluid resistance is low; no moving element is needed in the sorter, so that abrasion and blocking of the channel are avoided, and the pressure balance of fluid is facilitated.

Description

technical field [0001] The invention belongs to the technical field of microfluidic systems, in particular to a submicron particle sorter coupled with thermophoresis. technical background [0002] The microfluidic system is the main research direction of the lab-on-a-chip. It is a system that integrates sampling, dilution, mixing, reaction, detection, and separation. It can miniaturize complex biochemical analysis processes. It can reduce the consumption of sample liquid and detection liquid, and can also reduce energy consumption, and it can also improve the analysis speed and analysis accuracy. Therefore, microfluidic system technology has been widely used in environmental engineering, material engineering, medical testing and other fields. [0003] Particle sorting, such as biological cell sorting, particle separation in air, particle aggregation and sedimentation in water, etc., plays a very important role in materials engineering, medical engineering, and environmental...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 王瑞金刘湘琪朱泽飞
Owner HANGZHOU DIANZI UNIV
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