Application of fibroblast growth factor 21 to acute liver failure and alcoholic fatty livers

A technology for liver failure and fibroblasts, which is applied in the field of molecular biology, especially protein detection, can solve the problems of little knowledge and achieve the effect of early diagnosis sensitivity

Inactive Publication Date: 2016-01-06
WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
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Problems solved by technology

However, little is known about the relationship between FGF21 and chemical and drug-induced liver injury and alcoholic liver disease, both animal and clinical

Method used

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  • Application of fibroblast growth factor 21 to acute liver failure and alcoholic fatty livers
  • Application of fibroblast growth factor 21 to acute liver failure and alcoholic fatty livers
  • Application of fibroblast growth factor 21 to acute liver failure and alcoholic fatty livers

Examples

Experimental program
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Effect test

Embodiment 2

[0123] Example 2 Changes in the level of FGF21 in the mouse model of acute liver failure caused by acetaminophen (APAP)

[0124] 1. Animal grouping and drug treatment arrangement

[0125] Thirty 8-week-old C57BL / 6j mice were selected and divided into groups A and B, with 10 mice in each group. The mice in group A were intraperitoneally injected with APAP solution at a dose of 500 mg / kg, the mice in group B were given an equal volume of normal saline as a control, and the mice in group C were injected with APAP solution at a dose of 500 mg / kg intraperitoneally. Recombinant human FGF21 protein was administered at a dose of 1 mg / kg. Three groups of mice were collected blood samples from the tail vein before injection (0h) and 4h, 6h, 8h, 12h after injection, and sacrificed at 24h. Another 25 8-week-old C57BL / 6j mice were divided into groups I, II, III, IV and V, with 5 mice in each group. The mice in each group were intraperitoneally injected APAP solution according to the abo...

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Abstract

The invention discloses an early diagnosis index for chemical-induced and drug-induced acute liver failure and a diagnosis index, namely a fibroblast growth factor 21 (hereinafter referred to as FGF21), for alcoholic fatty liver diseases. The early diagnosis index and the diagnosis index have the advantages that an index with early diagnosis functions is urgently required as acute liver failure is short in disease course; the diagnosis index FGF21 has a characteristic that the diagnosis index FGF21 is sensitive as compared with existing glutamic-pyruvic transaminase and glutamic-oxalacetic transaminease, the recombinant human FGF21 can protect liver tissues against being injured by acetaminophen, and accordingly the early diagnosis index and the diagnosis index have excellent clinical application value.

Description

technical field [0001] The invention relates to the field of molecular biology, especially protein detection, in particular to the role of a serum protein in diagnosing and treating acute liver failure and alcoholic fatty liver. Background technique [0002] The liver is the largest metabolic organ in the human body. It is the central station for the metabolism and storage of many important substances, detoxification and excretion of metabolites, maintenance of water and electrolyte balance, adjustment of hormone metabolism and immune function. While protecting the body, the liver is easily damaged by various poisons, drugs and metabolites of compounds. When pathological changes occur in the liver, it will also lead to changes in systemic metabolites, blood circulation system, digestive system, endocrine system, etc., and affect the fate of endogenous small molecule metabolites. The incidence of liver disease has always occupied the forefront of various diseases. The resul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61P1/16
Inventor 林灼锋潘薛波吴帆李校堃金雷钢施立华邵怡辉张赛赛
Owner WENZHOU MEDICAL UNIV
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