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Application of 3,4-dihydroxybenzaldehyde in preparation of medicine for treating or/and preventing cerebral ischemia-reperfusion injury

A technology of dihydroxybenzaldehyde and cerebral ischemia-reperfusion, which is applied in the field of medicine and achieves the effects of significant curative effect, protection of nerve function, and inhibition of NO toxic reaction.

Active Publication Date: 2016-01-13
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far there is no public report about the pharmacological effects of 3,4-dihydroxybenzaldehyde on the prevention and treatment of cerebral ischemia-reperfusion injury

Method used

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  • Application of 3,4-dihydroxybenzaldehyde in preparation of medicine for treating or/and preventing cerebral ischemia-reperfusion injury
  • Application of 3,4-dihydroxybenzaldehyde in preparation of medicine for treating or/and preventing cerebral ischemia-reperfusion injury
  • Application of 3,4-dihydroxybenzaldehyde in preparation of medicine for treating or/and preventing cerebral ischemia-reperfusion injury

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Embodiment Construction

[0034] The raw materials, reagents and equipment used in the specific embodiments of the present invention are all known products, obtained by purchasing commercially available products.

[0035] The beneficial effects of the present invention are demonstrated below through experimental examples.

[0036] 1. Experimental materials

[0037] 1.1 Experimental animals

[0038] Adult healthy male SD rats, weighing 250-300 g, SPF grade, were provided by the Laboratory Animal Research Institute of Sichuan Academy of Medical Sciences, production license number: SCXK (Chuan) 2008-24, certificate number: 0017670.

[0039] 1.2 Experimental drugs

[0040] 3,4-Dihydroxybenzaldehyde, a transparent solid crystal obtained by the Kunming Institute of Botany of the Chinese Academy of Sciences from the EtOAc layer extract of Gastrodia elata. After the structure is determined, the monomer components used in this experiment are purchased from Sigma Company in the United States. .

[0041] In...

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Abstract

The invention discloses application of 3,4-dihydroxybenzaldehyde in preparation of medicine for treating or / and preventing a cerebral ischemia-reperfusion injury. Pharmacodynamic experiments show that the compound has the significant effects of protecting blood brain barriers and neurological functions and inhibiting a NO toxic reaction from occurring, and therefore the effect of treating or / and preventing the cerebral ischemia-reperfusion injury is achieved. Compared with similar medicine and treatment means which are clinically commonly used at present, the 3,4-dihydroxybenzaldehyde is wide in source, low in cost and significant in curative effect and has the good clinical application prospect.

Description

technical field [0001] The invention relates to the use of 3,4-dihydroxybenzaldehyde for preparing a medicine for treating or / and preventing cerebral ischemia-reperfusion injury, and belongs to the field of medicine. Background technique [0002] After cerebral ischemia restores blood supply for a certain period of time, its function not only fails to recover, but more serious brain dysfunction occurs, which is called cerebral ischemia-reperfusion (CIR) injury. At present, inhibition of reperfusion injury has become an important part of the treatment of ischemic cerebrovascular disease. [0003] Cerebral ischemia-reperfusion injury is a complex pathophysiological process, mainly related to various mechanisms such as excessive formation of free radicals, toxicity of excitatory amino acids, intracellular calcium overload, and inflammatory reactions. In recent years, research on the treatment of cerebral ischemia-reperfusion injury has achieved certain results. Clinically, mil...

Claims

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Application Information

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IPC IPC(8): A61K31/11A61P9/10
Inventor 林青何芳雁代蓉李秀芳
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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