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Cerebral protection perfusate based on interventional neuroradiology microcatheter technology and preparation method thereof

A neurointervention and microcatheter technology, applied in the field of brain protection medicine, can solve the problems of inability to improve the final curative effect of stroke treatment, missed stroke treatment time window, slow induction of target temperature, etc. low cost effect

Active Publication Date: 2012-07-04
XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current methods of implementing hypothermia (such as whole-body ice bath, ice cap, and inferior vena cava catheter cooling) have serious defects, which are reflected in the slow induction of the target temperature, often missing the treatment time window for stroke, and the serious damage caused by whole-body hypothermia. Complications also offset brain protection from hypothermia
[0004] And so far, no brain-protective drug has been clinically proven to have a definite brain-protective effect.
Recent animal experiments and clinical studies have confirmed that large doses of albumin can produce effective neuroprotective effects, and large doses of albumin may bring about some serious complications such as heart and pulmonary edema, etc. In the clinical trials that have been carried out, it is necessary to prevent The use of diuretics to reduce volume load, considering that a considerable number of ischemic stroke patients have heart and lung diseases at the same time, will seriously limit its application range
Although many other drugs can target a certain link of cerebral ischemic injury in animal experiments, they cannot improve the final curative effect of stroke treatment

Method used

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  • Cerebral protection perfusate based on interventional neuroradiology microcatheter technology and preparation method thereof
  • Cerebral protection perfusate based on interventional neuroradiology microcatheter technology and preparation method thereof
  • Cerebral protection perfusate based on interventional neuroradiology microcatheter technology and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Preparation of Example 1 Cerebral Protection Perfusate

[0050] Raw material concentration:

[0051] Albumin: 60g / L, sodium lactate: 5g / L, magnesium sulfate: 1g / L, sodium bicarbonate: 5g / L, furosemide: 0.04g / L.

[0052] Preparation of brain protection perfusion solution:

[0053] (1) Stir and dissolve 5g of sodium lactate, 0.04g of furosemide, and 1g of magnesium sulfate into 1000mL of water to prepare an aqueous solution, and then maintain the temperature of the solution at 0-4°C;

[0054] (2) Add 60g of albumin, stir evenly to maintain the osmotic pressure of the solution at 310±5mmol / kg; maintain the solution temperature at 0-4°C;

[0055] (3) At a temperature of 0-4°C, add 5 g of sodium bicarbonate to adjust the pH value of the solution to 7.45-7.50;

[0056] (4) Store the prepared above solution at a temperature of 0-4°C.

Embodiment 2

[0057] Preparation of embodiment 2 brain protection perfusion solution

[0058] Raw material concentration:

[0059] Albumin: 50g / L, sodium lactate: 6g / L, magnesium sulfate: 2g / L, sodium bicarbonate: 7g / L, furosemide: 0.06g / L,

[0060] Sodium chloride: 5g / L, potassium chloride: 0.3g / L, calcium chloride: 0.4g / L.

[0061] Preparation of brain protection perfusion solution:

[0062] (1) 6g sodium lactate, 0.04g furosemide, 2g magnesium sulfate, 5g sodium chloride, 0.3g potassium chloride, 0.4g calcium chloride were stirred and dissolved in 1000mL water to prepare an aqueous solution, and then the solution temperature was maintained at 0 ~4°C;

[0063] (2) Add 50g of albumin, stir evenly to maintain the osmotic pressure of the solution at 310±5mmol / kg; maintain the solution temperature at 0-4°C;

[0064] (3) At a temperature of 0-4°C, add 7g of sodium bicarbonate to adjust the pH value of the solution to 7.45-7.50;

[0065] (4) Store the prepared above solution at a temperatu...

Embodiment 3

[0066] Example 3 Animal experiment example of brain protection perfusate of the present invention

[0067] 1. Experimental group:

[0068] A total of 32 adult male SD rats (body weight 280-320g) were divided into 5 groups:

[0069] 1) Control group: no intervention after cerebral ischemia-reperfusion;

[0070] 2) Selective intravascular hypothermic brain protective perfusion solution group (prepared in Example 1): perfuse the microcatheter with low temperature (0°C) brain protective solution (3ml) immediately before cerebral ischemia-reperfusion;

[0071] 3) Selective intravascular normal temperature brain protection perfusion solution group: immediately before cerebral ischemia reperfusion, perfuse normal temperature (37°C) brain protection solution (3ml) into the microcatheter;

[0072] 4) Selective intravascular perfusion of hypothermic (0°C) normal saline (3ml);

[0073] 5) Normal temperature human serum albumin group given systemically via the femoral artery: the amoun...

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Abstract

The invention discloses a cerebral protection perfusate based on an interventional neuroradiology microcatheter technology, comprising albumin of which the concentration is 50-70, sodium lactate of which the concentration is 5-6, magnesium sulphate of which the concentration is 1-2, sodium bicarbonate of which the concentration is 4-7, furosemide of which the concentration is 0.04-0.06 and water as a solvent. Various medicine components of the invention have different nerve protection mechanisms and can intervene by synergistically aiming to various links of ischemia reperfusion injury; compared with independent application of various medicines, the medicine content of the cerebral protection perfusate is obviously decreased, thus reducing side effect or complication caused by medicine; each component of the cerebral protection perfusate is safe and reliable; the cerebral protection perfusate can quickly induce cerebral ischemia areas at low temperature, simultaneously avoids complication caused by whole body low temperature, has low cost and is easy to obtain.

Description

technical field [0001] The invention relates to a brain-protective drug for acute ischemic stroke, more specifically, a brain-protective solution for selectively perfusing ischemic brain tissue through interventional microcatheter technology in combination with arterial thrombolysis and its preparation method. Background technique [0002] Acute ischemic cerebrovascular disease is a common disease among middle-aged and elderly people with high disability and mortality. Early thrombolysis is the only clinically proven effective treatment. In recent years, with the enrichment of thrombolytic means, especially for acute occlusion of large vessels such as the middle cerebral artery, various measures to strengthen thrombolytic recanalization (such as contact thrombolysis, thrombus capture, intravascular ultrasound and laser devices, etc.) The clinical application of ) improves the rate of vascular recanalization, but also increases the incidence of complications, especially cer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/38A61P9/10A61K31/191A61K31/341A61K33/00A61K33/06
Inventor 凌锋吉训明罗玉敏陈健丁玉川陈俊曹国栋
Owner XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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