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Application of cyclocarya paliurus extract in preparation of medicine for treating stomach cancer

A technology of extracts and medicines, which is applied in the application field of Cyclocarya paliurus extracts in the preparation of gastric cancer medicines, can solve the problems of insignificant effects of traditional Chinese medicines and large side effects of western medicines, and achieve significant prevention and treatment, improved utilization rate, and good inhibitory effect Effect

Inactive Publication Date: 2016-01-13
吴申龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are many kinds of drugs for treating gastric cancer on the market, and the side effects of western medicine are large, while the effect of existing traditional Chinese medicine is not very significant
However, the impact of Cyclocarya paliurus on gastric cancer has not yet been reported in literature and patents.

Method used

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  • Application of cyclocarya paliurus extract in preparation of medicine for treating stomach cancer
  • Application of cyclocarya paliurus extract in preparation of medicine for treating stomach cancer
  • Application of cyclocarya paliurus extract in preparation of medicine for treating stomach cancer

Examples

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Effect test

Embodiment 1

[0022] The preparation of embodiment 1 Cyclocarya paliurus extract

[0023] (1) Taking new leaves of Cyclocarya paliurus as raw material, after cleaning, drying, crushing and sieving, put it in an extraction tank, add distilled water, the mass ratio of solid to liquid is 1:6, extract under pressure 4 times at 100°C, The pressure is controlled at 10 atmospheres, each extraction is 43h, and the extracts are combined to obtain the extract A;

[0024] (2) Soak the extract A in 10 times of ethanol and reflux 5 times, filter and concentrate, freeze-dry to obtain extract C;

[0025] (3) Take the above extract C and dissolve it in an appropriate amount of water, add n-butanol, stir and let stand at low temperature to separate layers, repeat the operation of the upper aqueous phase 4 times, dialyze with a dialysis membrane with a molecular weight cut-off of 10,000 for 2 days, and take out the dialysis bag The inner liquid was filtered, concentrated under reduced pressure, and freeze-d...

Embodiment 2

[0027] The preparation of embodiment 2 Cyclocarya paliurus extract

[0028] (1) The old leaves of Cyclocarya paliurus were used as raw materials, washed, dried, crushed and sieved, placed in an extraction tank, added distilled water, the mass ratio of solid to liquid was 1:7, and extracted under pressure for 3 times at 100°C, The pressure is controlled at 10 atmospheres, each extraction is 3 hours, and the extracts are combined to obtain the extract A;

[0029] (2) Soak the extract A in 14 times of ethanol and reflux 4 times, filter and concentrate, freeze-dry to obtain extract C;

[0030] (3) Take the above extract C and dissolve it in an appropriate amount of water, add n-butanol, stir and let stand at low temperature to separate layers, repeat the operation of the upper aqueous phase 4 times, dialyze with a dialysis membrane with a molecular weight cut-off of 10,000 for 2 days, and take out the dialysis bag The inner liquid was filtered, concentrated under reduced pressure...

Embodiment 3

[0032] The preparation of embodiment 3 Cyclocarya paliurus extract

[0033] (1) Take the fallen leaves of Cyclocarya paliurus as raw material, after cleaning, drying, crushing and sieving, put them in an extraction tank, add distilled water, the mass ratio of solid to liquid is 1:8, and extract under pressure for 4 times at 100°C. Control the pressure at 10 atmospheres, extract for 3 hours each time, and combine the extracts to obtain extract A;

[0034] (2) Soak the extract A in 18 times of ethanol and reflux 4 times, filter and concentrate, freeze-dry to obtain extract C;

[0035] (3) Take the above extract C and dissolve it in an appropriate amount of water, add n-butanol, stir and let stand at low temperature to separate layers, repeat the operation of the upper aqueous phase 4 times, dialyze with a dialysis membrane with a molecular weight cut-off of 10,000 for 2 days, and take out the dialysis bag The inner liquid was filtered, concentrated under reduced pressure, and f...

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Abstract

The invention discloses application of a cyclocarya paliurus extract in preparation of a medicine for treating stomach cancer. The cyclocarya paliurus extract with high content is obtained by carrying out water leaching on cyclocarya paliurus leaves, extracting, carrying out membrane dialysis and purification. The cyclocarya paliurus leaves are used as a raw material, the active ingredient of the cyclocarya paliurus is extracted, and the active ingredient is applied to preparation of the medicine for treating stomach cancer, so that the utilization rate of the cyclocarya paliurus leaves is improved; and the anticancer experiment research on in-vitro multiple human stomach tumor cells and in-vivo tumor cancer model finds that the cyclocarya paliurus extract has good inhibition effect on the in-vivo and in-vitro tumor cells and has very significant effect on preventing and controlling stomach cancer.

Description

technical field [0001] The invention relates to the technical field of application of traditional Chinese medicines, in particular to the application of Cyclocarya paliurus extract in the preparation of gastric cancer medicine. Background technique [0002] Gastric cancer is one of the common malignant tumors in my country, and its incidence rate ranks first among all kinds of tumors in China. The incidence rate of gastric cancer in China is highest in Northwest China, followed by Northeast China, Inner Mongolia, East China and coastal areas, and lowest in Central South and Southwest China. About 170,000 people die from gastric cancer every year, nearly 1 / 4 of all malignant tumor deaths, and there are more than 20,000 new patients every year. Gastric cancer seriously threatens the physical and mental health of human beings, and brings a heavy burden to patients (families), society and the country. [0003] Gastric cancer can occur at any age, but it is more common in 40-60...

Claims

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Application Information

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IPC IPC(8): A61K36/52A61P35/00A61K127/00
Inventor 吴申龙
Owner 吴申龙
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