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Treatment of gastrointestinal and other disorders

A technology for gastrointestinal diseases and large intestine, which is used in allergic diseases, medical preparations containing active ingredients, drug combinations, etc.

Inactive Publication Date: 2016-01-20
NUMEDII
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of corticosteroids is often associated with a number of systemic side effects, such as osteoporosis, diabetes, systemic hypertension, psychiatric disorders, and altered steroid metabolism

Method used

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  • Treatment of gastrointestinal and other disorders
  • Treatment of gastrointestinal and other disorders
  • Treatment of gastrointestinal and other disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1a

[0290] Example 1a: Parenteral Compositions

[0291] To prepare a parenteral pharmaceutical composition suitable for administration by injection, 80 mg of a compound of formula I described herein is dissolved in DMSO and then mixed with 10 mL of 0.8% sterile saline. The mixture is incorporated into unit dosage forms suitable for administration by injection.

Embodiment 1b

[0292] Example 1b: Oral Compositions

[0293] To prepare a pharmaceutical composition for oral delivery, 80 mg of a compound of formula I described herein is mixed with 8000 mg of starch. The mixture is incorporated into oral unit dosage forms suitable for oral administration, such as hard gelatin capsules.

Embodiment 1c

[0294] Example 1c: Sublingual (Hard Lozenge) Composition

[0295] To prepare a pharmaceutical composition for buccal delivery, such as a hard lozenge, 80 mg of a compound of formula I as described herein is mixed with 500 mg of powdered sugar which has been mixed with 1.6 mL of low corn syrup, 2.4 mL of distilled water and 0.42 mL cherry extract mixed. The mixture is mixed gently and poured into molds to form lozenges suitable for buccal administration.

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Abstract

Provided herein are methods and compositions for treating gastrointestinal disorders using beta blockers. Compositions comprising Beta blockers such as Timolol and Nadolol are used to treat diseases including ulcerative colitis, IBD and Crohn's disease. The Compositions are administered orally or rectally, at doses that provide a peak plasma concentration of less than 10ng / ml.

Description

[0001] cross reference [0002] This application claims the benefit of US Provisional Application No. 61 / 809,148, filed April 5, 2013, which is hereby incorporated by reference in its entirety for all purposes. technical field [0003] The present invention relates to the use of a beta blocker to treat a gastrointestinal disorder in a subject in need thereof, comprising administering the beta blocker to the subject. For example, the gastrointestinal disease is inflammatory bowel disease (IBD) or ulcerative colitis (UC). Background technique [0004] Gastrointestinal disorders include a wide range of conditions related to the digestive tract. For example, common gastrointestinal disorders include inflammation and ulceration of any part of the digestive tract, such as the esophagus, stomach, or duodenum. A substantial portion of the world's population experiences one or more gastrointestinal disorders at some time in their lives. For example, it is estimated that as many a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/135
CPCA61K9/0014A61K9/0031A61K9/0048A61K9/0056A61K9/0078A61K9/06A61K9/4866A61K31/138A61K31/5355A61K31/5377A61K31/573A61K45/06A61P1/00A61P1/04A61P1/10A61P1/12A61P29/00A61P37/02A61P43/00A61K9/0053A61K31/145A61K31/165A61K31/166A61K31/167
Inventor 乔尔·达德利卡罗尔·克里斯多佛潘卡杰·帕斯理查
Owner NUMEDII
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