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Application of 5-deoxystrigol in preparation of medicines for preventing and treating liver injury

A technology for liver damage and drugs, applied in the application field of 5-deoxystrigol in the preparation of drugs for the prevention and treatment of liver damage, which can solve the problems of liver damage, aggravation, and elevation, and achieve the effect of strong therapeutic activity and outstanding substantive characteristics

Inactive Publication Date: 2016-02-03
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certain congenital liver diseases, high-priced intravenous nutrition, etc., can all cause liver damage to varying degrees. The early manifestations of these liver damage are often Elevation of ALT (transaminase) or bilirubin, if the cause is not eliminated, the liver damage will be further aggravated

Method used

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  • Application of 5-deoxystrigol in preparation of medicines for preventing and treating liver injury
  • Application of 5-deoxystrigol in preparation of medicines for preventing and treating liver injury
  • Application of 5-deoxystrigol in preparation of medicines for preventing and treating liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: the preparation of compound 5-deoxystrigol tablet involved in the present invention:

[0011] Take 5 grams of compound 5-deoxystrigol, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional tableting.

Embodiment 2

[0012] Embodiment 2: the preparation of compound 5-deoxystrigol capsules involved in the present invention:

[0013] Get 5 grams of compound 5-deoxystrigol, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0014] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0015] Experimental Example 1.5-The effect of deoxystrigol on preventing and treating liver injury

[0016] (1) Protective effect of 5-deoxystrigol on D-galactosamine (D-GalN)-induced acute liver injury in mice

[0017] Kunming mice, weighing 18-22 grams, were taken from the Experimental Animal Center of Nanjing Medical University and divided into 5 groups. The control group was given intragastric administration of normal saline (0.3mL·d-1) for 7 consecutive days, and intraperitoneal injection of normal saline (0.15mL d-1) on the 7th day. ·10g-1); D-GalN, 5-deoxystrigol (1.5, 3.0, 6.0 mg·kg-1) each group was administered with normal saline and 5-deoxystrigol of different concentrations (0.3mL·d-1), continuously On the 7th day, D-GalN (800mg·kg-1, 0.15mL·10g-1) was injected intraperitoneally on the 7th day, and blood was collected 16 hours later to measure AST and ALT activities.

[0018] Protective effect of table 15-deoxystrigol on acute liver injury induced by D-GalN

[00...

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Abstract

The inventor discloses 5-deoxystrigol which has a protective effect on D-galactosamine (D-GalN) induced mice acute liver injury and has a protective effect on CCl4 induced mice acute liver injury. Thus, 5-deoxystrigol can be used in preparation of medicines for preventing and treating liver injury or hepatitis and is disclosed for the first time. As the skeleton type belongs to a brand-new skeleton type and 5-deoxystrigol has strong therapeutic activity on liver injury, 5-deoxystrigol has outstanding substantial characteristics and obviously has prominent progress when used in anti-liver injury.

Description

technical field [0001] The present invention relates to a new application of compound 5-deoxystrigol, in particular to the application of 5-deoxystrigol in the preparation of drugs for preventing and treating liver damage. Background technique [0002] There are multiple reasons for causing liver damage: 1. Viral infection: caused by a variety of hepatitis viruses, with strong infectivity, complex transmission routes, wide epidemic range, and high incidence rate. 2. Drugs or chemical poisons: Many drugs and chemical poisons can cause liver damage, drug-induced hepatitis or toxic hepatitis. 3. Alcoholism: Alcohol damages the liver very seriously. The consequences of the damage include alcoholic hepatitis, alcoholic fatty liver, and alcoholic cirrhosis, mainly due to the toxicity of alcohol (ethanol) and its metabolite acetaldehyde on liver cells. caused by direct damage. 4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P1/16
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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