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Cefuroxime axetil pharmaceutical composition and preparing method thereof

A technology for cefuroxime axetil and a composition is applied in the field of stable cefuroxime axetil composition and preparation thereof, which can solve the problems of inconvenience in large-scale production of measuring the bulk density of auxiliary materials, achieve controllable product quality, simple preparation method, Good dissolution performance

Inactive Publication Date: 2016-04-06
SHENZHEN SALUBRIS PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the disintegration and dissolution effects of the preparation thus obtained are improved, this technical solution often requires pretreatment (such as crushing, adding glidants, etc.) The inconvenience of mass production

Method used

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  • Cefuroxime axetil pharmaceutical composition and preparing method thereof
  • Cefuroxime axetil pharmaceutical composition and preparing method thereof
  • Cefuroxime axetil pharmaceutical composition and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The prescription is as follows:

[0042]

[0043]

[0044] The preparation steps are as follows:

[0045] 1. Put cefuroxime axetil, polyvinylpyrrolidone, sodium lauryl sulfate, hydrogenated castor oil and half of the prescription amount of silicon dioxide in a mixing granulator, stir and mix evenly, and pass through a 60-mesh sieve to obtain mixed powder A ;

[0046] 2. Add microcrystalline cellulose, croscarmellose sodium, and the remaining silicon dioxide to mixed powder A, pass through a 60-mesh sieve, and mix them evenly in a mixer to obtain mixed powder B;

[0047] 3. Add magnesium stearate to mixed powder B and mix evenly to obtain mixed powder C;

[0048] 4. Compress the mixed powder C into tablets with a pressure of 4.5-7.5 kg to obtain the cefuroxime axetil pharmaceutical composition.

Embodiment 2

[0050] The prescription is as follows:

[0051]

[0052] The same preparation steps as in Example 1 were adopted, and the pressure of 5.0-7.0 kg was used to compress the tablet to obtain the cefuroxime axetil pharmaceutical composition.

Embodiment 3

[0054] The prescription is as follows:

[0055]

[0056]

[0057] Using the same preparation steps as in Example 2, the cefuroxime axetil pharmaceutical composition was obtained.

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Abstract

The invention provides a cefuroxime axetil pharmaceutical composition. The cefuroxime axetil pharmaceutical composition has the advantages that digesting performance is high, the preparing method is simple, product quality is controllable, and the clinical medication risk is small.

Description

technical field [0001] The invention relates to a stable cephalosporin antibiotic composition and a preparation method thereof, in particular, the present invention relates to a stable cefuroxime axetil composition and a preparation method thereof. Background technique [0002] Cefuroxime Axetil (Cefuroxime Axetil, CAS64544-07-6), developed and listed by GSK Company, the trade name is Xilixin. Cefuroxime axetil is a second-generation cephalosporin antibiotic, which is the acetyl ethyl ester of cefuroxime, which belongs to the prodrug, and exerts its antibacterial activity by releasing cefuroxime through hydrolysis in the body. [0003] [0004] Cefuroxime axetil is a lipophilic compound and has the disadvantage of poor water solubility. It exists in crystal form and amorphous form, and the solubility of amorphous form is better than that of crystal form. Therefore, currently commercially available preparations mostly use amorphous cefuroxime axetil as an active ingredien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/546A61K47/38A61K47/32A61K47/20A61K47/04A61P31/04A61J3/10
Inventor 蔡燕霞陈淑君
Owner SHENZHEN SALUBRIS PHARMA CO LTD
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