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Masson pine bark extract for treating squamous cell lung carcinoma as well as preparation method and composition of masson pine bark extract

A technology of pine bark extract and Pinus massoniana, which is applied in the direction of drug combination, medical raw materials derived from gymnosperms, antineoplastic drugs, etc., to achieve the effects of maintaining integrity, improving resource utilization, and reducing solvent pollution

Active Publication Date: 2016-04-06
华创安全医疗科技(广东)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are some reports about the treatment of epidermal cancer and oral squamous cell carcinoma with the extract of Pinus massoniana, based on the difference in the pathogenesis of lung squamous cell carcinoma and epidermal squamous cell carcinoma, so far, no one has used Pinus massoniana bark extract to treat lung squamous cell carcinoma at home and abroad. , and there is no report about the extract from the bark of Pinus massoniana that can resist squamous cell carcinoma of the lung

Method used

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  • Masson pine bark extract for treating squamous cell lung carcinoma as well as preparation method and composition of masson pine bark extract
  • Masson pine bark extract for treating squamous cell lung carcinoma as well as preparation method and composition of masson pine bark extract
  • Masson pine bark extract for treating squamous cell lung carcinoma as well as preparation method and composition of masson pine bark extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 Preparation of Masson pine bark extract

[0055] The preparation method of pine bark extract comprises the following steps:

[0056] 1) screening no visible foreign matter, no rot, no mildew, and masson pine bark with moisture≤10%, after winnowing and removing impurities, drying at 50°C to obtain the masson pine bark dry product;

[0057] 2) 1.5Kg of Pinus massoniana bark dry product is pulverized to 400 orders, makes Pinus massoniana bark powder;

[0058] 3) At 15°C, add soft water to the masson pine bark powder for ultrasonic water extraction, wherein the mass volume ratio of masson pine bark powder to soft water is 1:2, and the ultrasonic extraction condition is that the ultrasonic power is 550W , ultrasonic 6s, gap 6s, ultrasonic 10min, made the masson pine bark ultrasonic water extract;

[0059] 4) Use a 100-mesh filter for primary filtration, then use raw white cloth to repeatedly adsorb and filter 4 times, take the filtrate and filter it through a 0...

Embodiment 2

[0061] Example 2 Preparation of Masson pine bark extract

[0062] The preparation method of pine bark extract comprises the following steps:

[0063] 1) screening no visible foreign matter, no rot, no mildew, and masson pine bark with moisture ≤ 10%, after winnowing and removing impurities, drying at 80°C to obtain a masson pine bark dry product;

[0064] 2) 2.0Kg of Pinus massoniana bark dried product is pulverized to 500 orders, makes the Pinus massoniana bark powder;

[0065] 3) At 25°C, add soft water to the bark powder of Pine massoniana for ultrasonic water extraction, wherein the mass volume ratio of the bark powder of Pine massoniana to soft water is 1:8, and the ultrasonic extraction condition is that the ultrasonic power is 550W , ultrasound 8s, gap 8s, ultrasound 12min, made the masson pine bark ultrasonic water extract;

[0066] 4) Use a 100-mesh filter for primary filtration, and then use raw white cloth to repeatedly absorb and filter for 5 times, take the fi...

Embodiment 3

[0068] The preparation of embodiment 3 masson pine bark extract

[0069] The preparation method of pine bark extract comprises the following steps:

[0070] 1) screening no visible foreign matter, no rot, no mildew, and masson pine bark with moisture≤10%, after winnowing and removing impurities, drying at 60°C to obtain a masson pine bark dry product;

[0071] 2) 2.5Kg of Pinus massoniana bark dry product is pulverized to 450 order, makes the Pinus massoniana bark powder;

[0072] 3) At 20°C, add soft water to the masson pine bark powder for ultrasonic water extraction, wherein the mass volume ratio of masson pine bark powder to soft water is 1:5, and the ultrasonic extraction condition is that the ultrasonic power is 600W , ultrasonic 10s, interval 10s, ultrasonic 10min, obtain the masson pine bark ultrasonic water extract;

[0073] 4) Use a 100-mesh filter for primary filtration, and then use raw white cloth to repeatedly absorb and filter for 6 times, take the filtrate and ...

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Abstract

The invention discloses a masson pine bark extract for treating squamous cell lung carcinoma as well as a preparation method and a composition of the masson pine bark extract. The preparation method of the extract comprises the following steps: (1) smashing masson pine bark till the size reaches 200-800 meshes, thus preparing masson pine bark powder; (2) at 4-25 DEG C, adding water into the masson pine bark powder, and soaking for 1-10 h, wherein the mass-to-volume ratio of the masson pine bark powder to the water is between 1 to 2 and 1 to 15; (3) carrying out ultrasonic extraction on the masson pine bark powder water soaking solution for 5min-2h, and filtering to prepare masson pine bark water extract solution; and (4) drying the masson pine bark water extract solution. The masson pine bark extract contains the active ingredients including polyphenol, total alkali and polysaccharide, has the effective rate reaching 95.75-99.66% in treating moderate or advanced squamous cell lung carcinoma, and has the advantages of small toxic and side effects, high safety and the like.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine extracts, in particular to a masson pine bark extract for preventing and treating lung squamous cell carcinoma, a preparation method and a composition thereof. Background technique [0002] The threat of cancer to human beings is increasing day by day, and it has gradually become the "number one killer" that endangers human health and life. Conquering cancer has become an urgent task facing all mankind. All countries regard it as an important subject and invest huge sums of money in researching it. Due to the limitations of surgical treatment, radiotherapy and chemical drug treatment of cancer, and the side effects of chemical drug treatment of cancer continue to appear, the international scientific community has begun to turn their attention to safer natural plant extracts, which have become a therapeutic option. cancer research hotspot. [0003] In the 1950s, Dr. Masquelie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/15A61P35/00A61K129/00
Inventor 张映波王力
Owner 华创安全医疗科技(广东)有限公司
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