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Application of ELL(C595A) mutant in promotion of tumor metastasis

A technology for tumor metastasis and tumor cells, applied in the direction of animal/human peptides, peptide sources, peptides, etc., can solve the problems of non-expression and inactivation

Active Publication Date: 2016-05-11
INST OF AQUATIC LIFE ACAD SINICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Of note, point mutations in FBW7 in human cancers can result in its inactivation and likely non-expression (Farrell and ears 2014)

Method used

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  • Application of ELL(C595A) mutant in promotion of tumor metastasis
  • Application of ELL(C595A) mutant in promotion of tumor metastasis
  • Application of ELL(C595A) mutant in promotion of tumor metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1, ELL (C595A) promotes tumor cell metastasis

[0064] 1. Tumor metastasis phenotype

[0065] The amino acid sequence of ELL (C595A) is a protein obtained by mutating the cysteine ​​at position 595 of ELL amino acid sequence 2 into alanine, and the nucleotide sequence of its encoded gene is the 1783,1784, 1783,1784, TGC at position 1785 was mutated to GCC.

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Abstract

The invention discloses an application of an ELL(C595A) mutant in the promotion of tumor metastasis. The invention provides at least one applications of ELL(C595A) protein of (1) to (6): (1) preparing products that promote tumor metastasis; (2) preparing products that promote tumor cell migration; (3) preparing products that can improve the performance on resisting tumor cell invasion; (4) preparing products that can increase the gene expression related with tumor metastasis; (5) preparing animal models that are used to screen and treat tumor metastasis; (6) preparing animal models that are applied to researches on tumor metastasis mechanism. The inventor finds that ELL mutant namely ELL(C595A) protein can promote tumor metastasis and improve the performance on resisting tumor cell invasion; and moreover, the ELL(C595A) protein can be used to prepare animal models that are used to screen and treat tumor metastasis and animal models that are applied to researches on tumor metastasis mechanism.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the application of ELL (C595A) in promoting tumor cell migration. Background technique [0002] The gene product of ELL was first defined as the translocated portion of the MLL gene in acute myeloid leukemia (AML) (Thirman et al. 1994). Further biochemical studies identified ELL as a transcriptional elongation factor that increases the transcriptional elongation activity of RNA polymerase II in vitro, and later in vivo studies revealed its associated transcriptionally active loci (Eissenberg et al. 2002, Shilatifard et al. 1996). ELL is part of two distinct elongation complexes, the super elongation complex (SEC) and the small elongation complex (LEC) (Hu et al. 2013, Luo et al. 2012, Smith and Shilatifard 2013). As one of the most active forms of the positive transcriptional elongation factor (P-TEFb), the super elongation complex (SEC) performs several important functions, such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/47
CPCC07K14/4702
Inventor 肖武汉陈瑜
Owner INST OF AQUATIC LIFE ACAD SINICA
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