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Essential amino-acids lactate peritoneal dialysis fluid medicinal composition

A technology for peritoneal dialysis fluid and composition, which is applied in the directions of drug combination, blood diseases, pharmaceutical formulations, etc., can solve the problem that the exact mechanism is not completely clear, and achieve the effects of improving amino acid spectrum and nitrogen balance.

Inactive Publication Date: 2016-06-08
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its characteristic is that the levels of most essential amino acids and total essential amino acids in plasma are reduced, while the levels of some non-essential amino acids are relatively high, especially after protein loading. The exact mechanism is not yet fully understood.

Method used

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  • Essential amino-acids lactate peritoneal dialysis fluid medicinal composition
  • Essential amino-acids lactate peritoneal dialysis fluid medicinal composition
  • Essential amino-acids lactate peritoneal dialysis fluid medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0043] Each liter of peritoneal dialysate consists of the following components

[0044]

[0045]

[0046] Preparation:

[0047] 1. Add 80% of the prescription amount of fresh water for injection (70-80°C) into the liquid dispensing tank, and mix and dissolve in the order of prescription under nitrogen flow.

[0048] 2. When the temperature of the liquid medicine drops to room temperature, adjust to 6≤PH<7 with hydrochloric acid, and make up to the full amount of water.

[0049] 3. Add activated carbon 0.1% (w / v), stir for about 30 minutes, and decarbonize.

[0050] 4. Use φ0.45μm+φ0.22μm double-layer microporous filter membrane to filter until the drug solution is clear, fill and stopper under the condition of nitrogen gas.

[0051] 5. Sterilize at 118°C for 15 minutes.

[0052] 6. Full inspection and packaging.

Embodiment 4-6

[0054] Each liter of peritoneal dialysate consists of the following components

[0055]

[0056]

[0057] Make 1000ml

[0058] Preparation:

[0059] The preparation method is the same as in Example 1-3.

Embodiment 7-9

[0061] Each liter of peritoneal dialysate consists of the following components

[0062]

[0063] Make 1000ml

[0064] Preparation:

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Abstract

The invention relates to a peritoneal dialysis fluid composition mainly containing 9 essential amino-acids but containing no glucose. With the peritoneal dialysis fluid composition, the contact time of the peritoneum and glucose can be reduced, the pH value of the amino-acids peritoneal dialysis fluid is relatively high and approaches to the physiologic property, so that the irritation to the peritoneum can be reduced. In addition, the amino-acids peritoneal dialysis fluid does not contain glucose, so that the generation of GDP can be avoided.

Description

Technical field [0001] The invention relates to a lactate peritoneal dialysate pharmaceutical composition which mainly contains 9 essential amino acids and does not contain glucose. Background technique [0002] Chronic renal insufficiency (CRF) refers to chronic progressive renal parenchymal damage caused by various reasons, which causes the kidneys to shrink significantly and cannot maintain basic functions. The clinical manifestations are retention of metabolites, imbalance of water, electrolyte, and acid-base balance, and the involvement of various systems throughout the body. The main clinical syndrome. The accumulation of toxins produced by protein metabolism in the body is one of the important pathogenesis of chronic renal insufficiency. The degree of uremia symptoms is directly related to the accumulation of protein metabolites. Low-protein diet can reduce the symptoms of uremia, and can reduce the further deterioration of chronic renal insufficiency. However, limiting...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61K33/14A61P13/12A61P7/08A61P3/14A61P3/12A61P3/02A61K31/405A61K31/198A61K33/06
Inventor 孙亮
Owner TIANJIN JINYAO GRP
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