Alkaline essential amino-acids lactate peritoneal dialysis fluid medicinal composition
A technology for peritoneal dialysis fluid and composition, which is applied in the directions of drug combination, active ingredients of alkaline/alkaline earth metal chloride, blood diseases, etc., can solve the problems of high cost, undetectable, increased patient risk, etc., and achieves improvement of nitrogen balance, improved The effect of amino acid profiles
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Embodiment 1-3
[0042] Each liter of peritoneal dialysate consists of the following components
[0043]
[0044]
[0045] Preparation:
[0046] 1. Concentrate preparation: take 20% of the prescription amount of water for injection, add the other ingredients of the prescription amount and stir until all of them are dissolved, then add 0.1-1% of medicinal charcoal, stir evenly, leave it for 10-20 minutes and pass through a 0.22μm terminal After filtration, steam sterilization at 115°C for 10 minutes to obtain a standby concentrate.
[0047] 2. Preparation of lye: prepare a tris solution with a content of 0.1mol / L, then add 0.1-1% medicinal charcoal and stir it evenly, stand for 10-20 minutes, then pass through a 0.22μm terminal filter, steam at 115°C Sterilize for 10 minutes to obtain lye for use.
[0048] 3. Mix the concentrated solution and lye at a uniform speed, adjust the solution to 1000ml with lye and water for injection, the PH value is the value in the above table, and then filter it through ...
Embodiment 4-6
[0055] Each liter of peritoneal dialysate consists of the following components
[0056] Ingredients
Example 4
Example 5
Example 6
Histidine (C 6 H 9 N 3 O 2 )
0.65g
0.714g
0.75g
Threonine (C 4 H 9 NO 3 )
0.6g
0.646g
0.7g
Valine (C 5 H 11 NO 2 )
1.3g
1.393g
1.5g
Methionine (C 15 H 11 NO 2 S)
0.8g
0.850g
0.9g
Isoleucine (C 6 H 13 NO 2 )
0.8g
0.850g
0.9g
Leucine (C 6 H 13 NO 2 )
1.0g
1.020g
1.1g
Phenylalanine (C 9 H 11 NO 2 )
0.50g
0.570g
0.60g
Tryptophan (C 11 H 12 N 2 O 2 )
0.25g
0.270g
0.35g
0.9g
0.955g
1.0g
[0057] (C 6 H 14 N 2 O 2 ·HCl)
Water for Injection
Margin
Margin
Margin
PH value
7.34
7.2
7.0
[0058] Make 1000ml
[0059] Preparation:
[0060] The preparation method is the same as in Example 1-3.
Embodiment 7-9
[0062] Each liter of peritoneal dialysate consists of the following components
[0063]
[0064] Make 1000ml
[0065] Preparation:
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