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Alkaline essential amino-acids lactate peritoneal dialysis fluid medicinal composition

A technology for peritoneal dialysis fluid and composition, which is applied in the directions of drug combination, active ingredients of alkaline/alkaline earth metal chloride, blood diseases, etc., can solve the problems of high cost, undetectable, increased patient risk, etc., and achieves improvement of nitrogen balance, improved The effect of amino acid profiles

Inactive Publication Date: 2016-06-08
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Therefore, the current pH value of peritoneal dialysate is ≤7. Even if the base is added, it is solved by the method of the double-chamber bag system, that is, the base and other divalent calcium and magnesium ions are stored in the double-chamber bag separately. Bases are mixed with divalent ions, but this method is costly. At the same time, bicarbonate and divalent calcium and magnesium ions are prone to local supersaturation during mixing, which increases the possibility of insoluble particles and cannot be detected. , which increases the patient's risk

Method used

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  • Alkaline essential amino-acids lactate peritoneal dialysis fluid medicinal composition
  • Alkaline essential amino-acids lactate peritoneal dialysis fluid medicinal composition
  • Alkaline essential amino-acids lactate peritoneal dialysis fluid medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0042] Each liter of peritoneal dialysate consists of the following components

[0043]

[0044]

[0045] Preparation:

[0046] 1. Concentrate preparation: take 20% of the prescription amount of water for injection, add the other ingredients of the prescription amount and stir until all of them are dissolved, then add 0.1-1% of medicinal charcoal, stir evenly, leave it for 10-20 minutes and pass through a 0.22μm terminal After filtration, steam sterilization at 115°C for 10 minutes to obtain a standby concentrate.

[0047] 2. Preparation of lye: prepare a tris solution with a content of 0.1mol / L, then add 0.1-1% medicinal charcoal and stir it evenly, stand for 10-20 minutes, then pass through a 0.22μm terminal filter, steam at 115°C Sterilize for 10 minutes to obtain lye for use.

[0048] 3. Mix the concentrated solution and lye at a uniform speed, adjust the solution to 1000ml with lye and water for injection, the PH value is the value in the above table, and then filter it through ...

Embodiment 4-6

[0055] Each liter of peritoneal dialysate consists of the following components

[0056] Ingredients

Example 4

Example 5

Example 6

Histidine (C 6 H 9 N 3 O 2 )

0.65g

0.714g

0.75g

Threonine (C 4 H 9 NO 3 )

0.6g

0.646g

0.7g

Valine (C 5 H 11 NO 2 )

1.3g

1.393g

1.5g

Methionine (C 15 H 11 NO 2 S)

0.8g

0.850g

0.9g

Isoleucine (C 6 H 13 NO 2 )

0.8g

0.850g

0.9g

Leucine (C 6 H 13 NO 2 )

1.0g

1.020g

1.1g

Phenylalanine (C 9 H 11 NO 2 )

0.50g

0.570g

0.60g

Tryptophan (C 11 H 12 N 2 O 2 )

0.25g

0.270g

0.35g

Lysine Hydrochloride

0.9g

0.955g

1.0g

[0057] (C 6 H 14 N 2 O 2 ·HCl)

Water for Injection

Margin

Margin

Margin

PH value

7.34

7.2

7.0

[0058] Make 1000ml

[0059] Preparation:

[0060] The preparation method is the same as in Example 1-3.

Embodiment 7-9

[0062] Each liter of peritoneal dialysate consists of the following components

[0063]

[0064] Make 1000ml

[0065] Preparation:

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Abstract

The invention relates to an alkalescent peritoneal dialysis fluid composition mainly containing 9 amino-acids but containing no glucose. Tris(hydroxymethyl)aminoethane is adopted for regulating the pH value, so that the contact time of the peritoneum and glucose can be reduced, and the pH value of the alkalescent peritoneal dialysis fluid approaches to the physiologic property, so that the irritation to the peritoneum can be reduced. In addition, the amino-acids dialysis fluid does not contain glucose, so that the generation of GDP can be avoided.

Description

Technical field [0001] The invention relates to an alkaline lactate peritoneal dialysate pharmaceutical composition which mainly contains 9 essential amino acids and does not contain glucose. Background technique [0002] Chronic renal insufficiency (CRF) refers to chronic progressive renal parenchymal damage caused by various reasons, which causes the kidneys to shrink significantly and cannot maintain basic functions. The clinical manifestations are retention of metabolites, imbalance of water, electrolyte, and acid-base balance, and the involvement of various systems throughout the body. The main clinical syndrome. The accumulation of toxins produced by protein metabolism in the body is one of the important pathogenesis of chronic renal insufficiency. The degree of uremia symptoms is directly related to the accumulation of protein metabolites. Low-protein diet can reduce the symptoms of uremia, and can reduce the further deterioration of chronic renal insufficiency. However...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61K33/14A61P13/12A61P7/08A61P3/02A61P3/12A61P19/10A61K31/198A61K31/405
Inventor 孙亮
Owner TIANJIN JINYAO GRP
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