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Low-calcium amino-acids (15) peritoneal dialysis fluid medicinal composition

A peritoneal dialysate and composition technology, applied in the field of low-calcium peritoneal dialysate compositions, can solve problems such as the exact mechanism is not completely clear, and achieve the effects of reducing metabolic burden, correcting amino acid spectrum disorder, and improving amino acid spectrum

Inactive Publication Date: 2016-06-08
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its characteristic is that the levels of most essential amino acids and total essential amino acids in plasma are reduced, while the levels of some non-essential amino acids are relatively high, especially after protein loading. The exact mechanism is not yet fully understood.

Method used

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  • Low-calcium amino-acids (15) peritoneal dialysis fluid medicinal composition
  • Low-calcium amino-acids (15) peritoneal dialysis fluid medicinal composition
  • Low-calcium amino-acids (15) peritoneal dialysis fluid medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0036] Each liter of peritoneal dialysis fluid consists of the following components

[0037]

[0038]

[0039] Preparation:

[0040] 1. Add 80% of the prescription amount of fresh water for injection (70-80°C) into the liquid mixing tank, feed the ingredients according to the order of the prescription under nitrogen flow, and stir to dissolve.

[0041] 2. When the temperature of the medicinal solution drops to room temperature, adjust it to 6≤PH<7 with hydrochloric acid, and replenish water to the full amount.

[0042] 3. Add activated carbon 0.1% (w / v), stir for about 30 minutes, and decarbonize.

[0043] 4. Filter with a φ0.45μm + φ0.22μm double-layer microporous membrane until the liquid medicine is clear, fill it with nitrogen, and stopper.

[0044] 5. Sterilize at 118°C for 15 minutes.

[0045] 6. Full inspection and packaging.

Embodiment 4-6

[0047] Each liter of peritoneal dialysis fluid consists of the following components

[0048]

[0049]

[0050] Make 1000ml

[0051] Preparation:

Embodiment 1

[0054] According to the partial amino acid prescription in Table 2 on page 331 of "The Impact of Amino Acid Peritoneal Dialysis on the Nutritional Status of Patients with Peritoneal Dialysis" (Journal of Nephrology and Dialysis and Kidney Transplantation, Volume 13, No. 4, August 2004, 330-332) See the table below) to prepare peritoneal dialysis solution, the preparation method is the same as in Example 1

[0055] essential amino acid

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Abstract

The invention relates to a low-calcium peritoneal dialysis fluid composition mainly containing 15 amino-acids but containing no glucose. With the low-calcium peritoneal dialysis fluid composition, the contact time of the peritoneum and glucose can be reduced, and the pH value of the amino-acids peritoneal dialysis fluid is relatively high and approaches to the physiologic property, so that the irritation to the peritoneum can be reduced. In addition, the amino-acids peritoneal dialysis fluid does not contain glucose, so that the generation of GDP can be avoided.

Description

technical field [0001] The invention relates to a low-calcium peritoneal dialysis fluid composition mainly containing 15 kinds of amino acids and not containing glucose. Background technique [0002] Chronic renal insufficiency (CRF) refers to chronic progressive renal parenchymal damage caused by various reasons, resulting in obvious atrophy of the kidneys, unable to maintain basic functions. The main clinical syndrome. The accumulation of toxins produced by protein metabolism in the body is one of the important pathogenesis of chronic renal insufficiency. The degree of uremic symptoms is directly related to the accumulation of protein metabolites. A low-protein diet can reduce the symptoms of uremia and slow down the further deterioration of chronic renal insufficiency. However, restricting protein can lead to a lack of essential amino acids in the body. In the past ten years, with the increasing clinical application of peritoneal dialysis technology, the survival peri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4172A61P7/08A61P13/12A61K31/405A61K31/401A61K31/198A61K31/195
Inventor 孙亮
Owner TIANJIN JINYAO GRP
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