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Methods of treating and preventing radiation damage

A technology of radiation damage and radiation absorption, which is used in pharmaceutical formulations, antibody medical ingredients, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2016-08-10
CANTEX PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Currently, there are no drugs approved for the prevention or treatment of radiation injury associated with whole body radiation

Method used

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  • Methods of treating and preventing radiation damage

Examples

Experimental program
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Effect test

Embodiment 1

[0080] Example 1. Survival of CD2F1 mice irradiated at 9.25 Gy and injected subcutaneously with 25 mg / kg ODSH after TBI (total body irradiation) This experiment demonstrates that after whole body irradiation Interval administration of ODSH improved the survival of mice. (see Figure 1)

[0081] Materials and Methods: CD2F1 male mice (Lot#7586DOB 12 / 23 / 2012) were weighed and animals outside the mean weight ±20% were excluded. Mice within ±20% of the mean weight were randomized into groups of 8 animals per box. There were 24 animals per treatment group. The animals received radiation at a dose rate of 0.6 Gy / min in the AFRRI cobalt 60 gamma irradiation facility. Animals were irradiated in Lucite boxes (8 animals / box) and arrayed using plastic racks (dosimetry 02 / 25 / 2010). Animals were restrained for no more than 60 min and returned to their cages at the end of the irradiation process.

[0082] After TBI, animals were either untreated (untreated) or treated subcutaneously wit...

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Abstract

The invention relates to methods of treating and preventing radiation damage from whole-body exposure. According to the methods of the invention, subjects are treated therapeutically and / or prophylactically with low-anticoagulant heparinoids. The invention also relates to methods of extending the life of subjects exposed to whole-body radiation.

Description

technical field [0001] The present invention relates to methods of treating and preventing radiation damage resulting from whole body radiation exposure. Background technique [0002] In the event of a nuclear attack or damage to a nuclear reactor, large numbers of people are exposed to whole body radiation in varying doses and are therefore at risk of developing some degree of acute radiation syndrome (ARS). ARS, also colloquially known as radiation poisoning, is a cluster of health problems that develop shortly after a subject is exposed to high levels of ionizing radiation. ARS is initially characterized by headache, nausea, and vomiting, but can progress to dysfunction of the blood, gastrointestinal tract, nerves, lungs, and other major organs. [0003] The severity of symptoms and prognosis of ARS are directly related to the radiation dose absorbed. LD with whole body radiation 50 / 60 (The dose that kills 50% of the subjects within 60 days) is about 3Gy. Under medica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00
CPCA61K31/727A61P1/00A61P1/08A61P1/12A61P17/16A61P31/04A61P35/00A61P7/00A61P7/04A61P7/06A61K9/0019A61K9/0021A61K45/06A61K2300/00
Inventor S.马库斯
Owner CANTEX PHARMA
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