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Preparation method of dual-targeted drug carrier based on magnetic metal-organic framework materials

An organic framework and magnetic metal technology, applied in the field of biomedical functional material preparation, can solve the problems of agglomeration, affecting the therapeutic effect, poor dispersibility of the drug carrier, etc., and achieve the effect of inhibiting growth and enhancing slow-release performance.

Inactive Publication Date: 2019-06-28
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Usually, the drug carrier has the following disadvantages. The size is too large and it is not easy to be phagocytized by cells, which affects the therapeutic effect. Secondly, the drug is unstable under normal physiological conditions, the drug loading is not large, and the drug carrier has poor dispersion, which is easy to cause agglomeration , resulting in poor therapeutic effect (Jia Zhuang, Chun-Hong Kuo, Lien-Yang Chou, De-Yu Liu, Eranthie Weerapana, and Chia-Kuang Tsung, Optimized metal organic framework nanospheres for drug delivery: evaluation of small-molecule encapsulation, ACSNANO 2014 (8) 2812–2819.)

Method used

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  • Preparation method of dual-targeted drug carrier based on magnetic metal-organic framework materials
  • Preparation method of dual-targeted drug carrier based on magnetic metal-organic framework materials
  • Preparation method of dual-targeted drug carrier based on magnetic metal-organic framework materials

Examples

Experimental program
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Effect test

Embodiment 1

[0043] (1) Ferric oxide (Fe 3 o 4 ) preparation:

[0044] Add 4.0g of ferric chloride hexahydrate, 7.1g of sodium acetate and 35mL of ethylene glycol into a 100mL flask, and ultrasonically disperse it. The mixture is stirred at 160°C for 1h under the protection of nitrogen, then transferred to a 50mL reaction vessel, and heated at 200°C React for 10h, then cool to room temperature, black magnetic Fe 3 o 4 Wash several times with absolute ethanol and dry, and finally dry in vacuum at 60°C.

[0045] (2) Fe3O4-coated dopamine (Fe 3 o 4 @PDA) Preparation:

[0046] First add 0.3g of trihydroxymethylaminomethane to 240mL of distilled water to prepare an aqueous solution of trihydroxymethylaminomethane, add 0.3g of dopamine hydrochloride to the aqueous solution of trihydroxymethylaminomethane, and then add 0.19g of Fe 3 o 4 Added into the above reaction system, and mechanically stirred for 24h, finally washed with distilled water several times and baked at 60°C in vacuum for ...

Embodiment 2

[0059] (1) Ferric oxide (Fe 3 o 4 ) preparation:

[0060] Add 4.1g of ferric chloride hexahydrate, 7.3g of sodium acetate and 45mL of ethylene glycol into a 100mL flask, and ultrasonically disperse it. The mixture is stirred at 160°C for 1h under the protection of nitrogen, then transferred to a 50mL reaction kettle, and heated at 200°C React for 10h, then cool to room temperature, black magnetic Fe 3 o 4 Wash several times with absolute ethanol and dry, and finally dry in vacuum at 60°C.

[0061] (2) Fe3O4-coated dopamine (Fe 3 o 4 @PDA) Preparation:

[0062] First add 0.4g of trishydroxymethylaminomethane to 260mL of distilled water to prepare an aqueous solution of trishydroxymethylaminomethane, add 0.4g of dopamine hydrochloride to the aqueous solution of trishydroxymethylaminomethane, and then add 0.21g of Fe 3 o 4 Added into the above reaction system, and mechanically stirred for 24h, finally washed with distilled water several times and baked at 60°C in vacuum ...

Embodiment 3

[0069] (1) Ferric oxide (Fe 3 o 4 ) preparation:

[0070] Add 4.05g of ferric chloride hexahydrate, 7.2g of sodium acetate and 40mL of ethylene glycol into a 100mL flask, and ultrasonically disperse it. The mixture is stirred at 160°C for 1h under the protection of nitrogen, and then transferred to a 50mL reaction vessel. React for 10h, then cool to room temperature, black magnetic Fe 3 o 4 Wash several times with absolute ethanol and dry, and finally dry in vacuum at 60°C.

[0071] (2) Fe3O4-coated dopamine (Fe 3 o 4 @PDA) Preparation:

[0072] First add 0.3g of trihydroxymethylaminomethane to 250mL of distilled water to prepare an aqueous solution of trihydroxymethylaminomethane, add 0.3g of dopamine hydrochloride to the aqueous solution of trihydroxymethylaminomethane, and then add 0.2g of Fe 3 o 4 Added into the above reaction system, and mechanically stirred for 24h, finally washed with distilled water several times and baked at 60°C in vacuum for 12h.

[0073] ...

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Abstract

The invention relates to a preparation method of a dual-targeting drug carrier based on a magnetic metal organic framework material, belonging to the technical field of preparation of bio-medicinal functional materials. The preparation method comprises the following steps: firstly, modifying ferroferric oxide to form dopamine-wrapping ferroferric oxide, and preparing the dual-targeting drug carrier based on the magnetic metal organic framework material by taking dopamine-wrapping ferroferric oxide (Fe3O4@PDA) as the matrix material; and carrying out a series of treatment to obtain an adsorbent, and carrying out selective recognition and separation on adriamycin in an aqueous solution by adopting the adsorbent. The dual-targeting drug carrier based on the magnetic metal organic framework material prepared by adopting the method provided by the invention has good heat stability and very large medicine-carrying capacity, has the acid-base effect, and also has the function of controlling medicine release.

Description

technical field [0001] The invention relates to a preparation method of a dual-target drug carrier based on a magnetic metal organic framework material, and belongs to the technical field of preparation of biomedical functional materials. Background technique [0002] With the deepening understanding of tumor cell biology and genetics, new treatment methods and treatment methods are also emerging, cancer treatment research has made considerable progress, and tumor targeted therapy has become a new hot spot . At present, most drug carriers only have a single drug-loading performance, and do not have the ability to recognize cancer cells. The targeted drug carrier can prevent the local concentration of the drug from being too high, reduce the loss and degradation of the drug, reduce its side effects, improve the utilization efficiency, and achieve the purpose of sustained release, controlled release, and targeted drug delivery. At present, studies have shown that targeting s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/60A61K47/02A61K47/34A61K47/18A61K47/24A61K31/704A61P35/00
CPCA61K31/704A61K47/02A61K47/10A61K47/18A61K47/24
Inventor 刘树成潘建明朱恒佳周永超苑东
Owner JIANGSU UNIV
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