Extraction technology of active substances in Thelephora ganbajun Zang and application of active substances in Thelephora ganbajun Zang

An extraction process and technology for active substances, applied in the direction of medical preparations containing active ingredients, antibacterial drugs, drug combinations, etc., can solve the problems of long time consumption, low extraction efficiency, low output, etc., to maintain activity, method easy effect

Inactive Publication Date: 2016-10-26
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the commonly used immersion and Soxhlet extraction methods can extract the active substances in Dried bacteria, these methods have low extraction efficiency, complicated extraction process, long time consumption, low output, and easy to destroy the activity of the extracted substances.

Method used

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  • Extraction technology of active substances in Thelephora ganbajun Zang and application of active substances in Thelephora ganbajun Zang
  • Extraction technology of active substances in Thelephora ganbajun Zang and application of active substances in Thelephora ganbajun Zang
  • Extraction technology of active substances in Thelephora ganbajun Zang and application of active substances in Thelephora ganbajun Zang

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1, Extraction I of Dried Bacteria Active Substance

[0021] Use a clean plastic blade to remove impurities on the surface of fresh edible fungi, dry them to constant weight, and crush them into 100 meshes with a cooking machine after removing impurities. Weigh 3g of fungi samples, add 70.15mL of extract, and the extract is 57.38% (v / v) Ethanol solution. After 4 hours of low-temperature treatment at -30°C, ultrasonication was performed at 40°C for 10 minutes at a frequency of 500w. Centrifuge at 5000r for 30 min and collect the supernatant. The supernatant was evaporated to dryness at 40°C, and the mass of the active substance obtained by weighing was 0.76 g.

Embodiment 2

[0022] Embodiment 2, the extraction II of dry bacteria active substance

[0023] Use a clean plastic blade to remove impurities on the surface of fresh edible fungi, dry them to constant weight, and crush them into 100 meshes with a cooking machine after removing impurities. Weigh 3g of fungi samples, add 70.15mL of extract, and the extract is 57.38% (v / v) Ethanol solution. After being treated at -20°C for 6 hours, ultrasonication was performed at 40°C for 10 minutes at a frequency of 500w. Centrifuge at 5000r for 30 min and collect the supernatant. The supernatant was evaporated to dryness at 40°C, and the mass of the active substance obtained by weighing was 0.84 g.

Embodiment 3

[0024] Embodiment 3, the extraction III of dried fungus active substance

[0025] Use a clean plastic blade to remove impurities on the surface of fresh edible mushrooms, dry them to constant weight, and crush them into 25 meshes with a cooking machine after removing impurities. )weak. After 6 hours of low-temperature treatment at -20°C, ultrasonication was performed at 75°C for 15 minutes at a frequency of 550w. Centrifuge at 5000r for 30 min and collect the supernatant. The supernatant was evaporated to dryness at 40°C, and the mass of the active substance obtained by weighing was 0.72 g.

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Abstract

The invention discloses an extraction technology of active substances in Thelephora ganbajun Zang. The extraction technology is simple, convenient and fast, is applicable to large-scale industrial production and can keep activity of chemical components in the Thelephora ganbajun Zang to the greatest extent. With the adoption of the chemical active substances extracted with the method, cancer cell growth can be inhibited remarkably, and good anti-oxidative and anti-bacterial effects are realized.

Description

technical field [0001] The invention relates to a process for extracting active substances, in particular to a process for extracting active substances in dry fungus. Background technique [0002] Ganba fungus is a rare wild edible fungus unique to Yunnan Province, also known as the fungus on the flower and the fungus on the horse. It grows among the pine trees in the mountain forests in central and western Yunnan. It is produced in the rainy season of July and August, and has not yet been cultivated artificially. When the dry fungus is unearthed, it is yellowish brown, and when it is mature, it turns dark brown. Dried bacterium is rich in calcium, iron, protein, thiamine, and has high nutritional value. [0003] At present, domestic and foreign researches on the application of Dried Bacteria mainly focus on the strain isolation, proliferation promotion, fermentation and preparation of seasonings containing Dried Bacteria. However, there are almost no reports on the extra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61P35/00A61P39/06A61P31/04
CPCA61K36/07A61K2236/333A61K2236/53
Inventor 李华斌徐冬平李莎郑洁周玥周通
Owner SUN YAT SEN UNIV
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