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Nano channel prism waveguide to enhance biomolecule terahertz characteristic signal in solution and preparation method thereof

A technology of biomolecules and prism waveguides, which is applied in the field of terahertz biomolecular detection, can solve problems such as low dynamic range, and achieve the effect of improving the signal-to-noise ratio and enhancing the characteristic absorption signal.

Active Publication Date: 2016-11-02
CHONGQING INST OF GREEN & INTELLIGENT TECH CHINESE ACADEMY OF SCI
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  • Application Information

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Problems solved by technology

However, in the above method, the terahertz beam only passes through the channel chip with a thickness of hundreds of nanometers, so the optical path of the interaction between the terahertz wave and the sample is limited by the depth of the receiving channel, which makes the absorption signal of biomolecules in the solution relative to that of the buffer. The dynamic range of the reference signal is very low, and it is necessary to repeatedly compare the sample signal and the reference signal to determine the characteristic absorption peak

Method used

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  • Nano channel prism waveguide to enhance biomolecule terahertz characteristic signal in solution and preparation method thereof
  • Nano channel prism waveguide to enhance biomolecule terahertz characteristic signal in solution and preparation method thereof
  • Nano channel prism waveguide to enhance biomolecule terahertz characteristic signal in solution and preparation method thereof

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Embodiment 1

[0046] The preparation method of the nanochannel prism waveguide is as follows:

[0047] 1) SiO with a thickness of 800nm ​​is formed on the upper surface of the silicon prism by thermal oxidation 2 layer;

[0048] 2) On SiO 2 Layer etch thickness and SiO 2 The layers are consistent, and the width is 800nm, and the arrayed nanochannels are regularly arranged, and the distance between two adjacent channels is 800nm;

[0049]3) Take the glass sheet, and use wet etching to etch a microchannel perpendicular to the nanochannel at the corresponding position of the glass sheet. The microchannel is 400 μm wide and 50 μm deep;

[0050] 4) Through laser drilling, the inlet and outlet holes are punched at both ends of the micro flow channel of the glass sheet;

[0051] 5) By anodic bonding, the prism silicon mirror with arrayed nanochannels prepared in step 2) is bonded to the glass sheet prepared in step 4), so that the microchannels are connected to each nanochannel and a seal is f...

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Abstract

The invention discloses a nano channel prism waveguide to enhance biomolecule terahertz characteristic signal in solution. The nano channel prism waveguide includes terahertz multiple attenuation total reflection (M-ATR) prism 1, regularly arranged array-type nano channels 2, a cover plate 3, and terahertz wave coupling surfaces 4. The array-type nano channels 2 are arranged on upper and lower surfaces of the terahertz M-ATR prism 1; the cover plate 3 is used for sealing the nano channel a; the contact surface of the cover plate 3 with the array-type nano channel structure 2 is provided with a micro channel 31 vertical to the nano channel 2; the micro channel 31 is provided with a sample inlet and outlet hole 32; and the terahertz wave coupling surfaces 4 are arranged in two ends of the terahertz M-ATR prism 1. The nano channel prism waveguide can enhance the terahertz characteristic absorption signal and improve the signal to noise ratio of the characteristic spectrum in the biological molecule terahertz spectrum detection in solution environment.

Description

technical field [0001] The invention relates to a terahertz biomolecule detection technology, in particular to a nanochannel prism waveguide for enhancing terahertz characteristic signals of biomolecules in a solution and a preparation method thereof. Background technique [0002] The terahertz spectrum of biomolecules contains rich physical and chemical information, which can directly reflect the low-frequency vibrations of molecules. These vibrations are directly related to the spatial conformation of biomolecules and the corresponding chemical properties and biological functions. Therefore, terahertz spectroscopy is an effective biodetection technique. [0003] In view of the fact that biomolecules such as proteins can realize various life functions only in the water environment, it is more practical to detect the terahertz spectrum of active biomolecules in physiological solution. However, the strong absorption of terahertz waves by water has always been an obstacle to ...

Claims

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Application Information

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IPC IPC(8): G01N21/01G01N21/31
CPCG01N21/01G01N21/31G01N2201/0873
Inventor 张明焜魏东山杨忠波夏良平颜识涵汤明杰施长城崔洪亮杜春雷
Owner CHONGQING INST OF GREEN & INTELLIGENT TECH CHINESE ACADEMY OF SCI
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