Preparation method of monomeric substances in Chinese Trillium tschonoskii Maxim. and rhizoma paridis medicinal materials and application of monomeric substances to preparation of medicine for treating Alzheimer disease

A technology for Alzheimer's disease and trillium, applied in the field of traditional Chinese medicine preparation

Inactive Publication Date: 2016-11-23
张忠立
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above studies have not been reported yet. Through systematic in vitro experimental research, we first found that it has effects on aging, sleep disorders, cardiovascular and cerebrovascular diseases (heart disease, hyperten

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of monomeric substances in Chinese Trillium tschonoskii Maxim. and rhizoma paridis medicinal materials and application of monomeric substances to preparation of medicine for treating Alzheimer disease
  • Preparation method of monomeric substances in Chinese Trillium tschonoskii Maxim. and rhizoma paridis medicinal materials and application of monomeric substances to preparation of medicine for treating Alzheimer disease
  • Preparation method of monomeric substances in Chinese Trillium tschonoskii Maxim. and rhizoma paridis medicinal materials and application of monomeric substances to preparation of medicine for treating Alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Pinanogenin-3- O -α- L -rhamnopyranosyl(1→2)- O -β- D -Glucopyranoside, pinanogenin-3- O -α- L -rhamnopyranosyl(1→4)-[- O -α- L -rhamnopyranosyl (1→2)]- O -β- D -Glucopyranoside, pinanogenin-3- O -α- L -rhamnopyranosyl(1→4)- O -α- L -Rhamnopyranosyl (1→4)-[ O -α- L -rhamnopyranosyl (1→2)]- O -β- D -Glucopyranoside, pinosapogenin-3β- O -β- D -Glucopyranosyl (1→6)-[ O -α- L -rhamnopyranosyl (1→2)]- O -β- D -Glucopyranoside, 27-Hydroxy-Pinogenin-3β-O-β-D-Glucopyranosyl (1→6)-[ O -α-L-rhamnopyranosyl (1→2)]- O - The preparation method of β-D-glucopyranoside, 3-acetyl-pinanoside I, dioscoreanoside I: the root and rhizome or fruit or whole grass of Chinese Trillium or Pachyphylla medicinal materials are pulverized into coarse powder , soaked in 60% ethanol for 1 hour, heated and refluxed 10 times the amount of solvent to extract 3 times, 2 hours each time, filtered, and combined the filtrates. The above filtrate was concentrated under reduced pressure...

Embodiment 2

[0048] Trillenoside A, deoxytrillenoside A, 24-acetyl-

[0049] deoxytrill-enoside A, 24-epiacetyl-deoxytrillenoside A, 24-methoxy-trillenoside A, trillenoside B, 24-acetyl-trillenoside B, 24-acetyl-deoxytrillenoside B, trillenoside C, Epitrillenogenin-24-O-acetate-1-O -[2,3,4-tri-O-acetyl-α-L-rhamnopyra-nosyl-(1

[0050] →2)-α-L-arabinopyranoside], Epitrillenogenin-1-O-[2,3,4-tri-O-acetyl-α-L-rhamnopy-

[0051] ranosyl-(1→2)-α-L-arabinopyranosi-de], Epitrillenogenin-24-O-acetate-1-O-[2,4-di-O-

[0052] acetyl-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside], Epitrillenogenin-1-O-

[0053] [2,4-di-O-acetyl-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside], Epitrillenogen-

[0054]The preparation method of in-1-O-[4-O-acetyl-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside]: the roots and rhizomes of Chinese Trillium or Pachyphylla Or the fruit or whole grass is crushed into coarse powder, soaked in 70% ethanol for 2.0 hours, 12 times the amount of solvent is heated to reflux...

Embodiment 3

[0056] Diosgenin-3- in the diosgenin substances contained in the roots, rhizomes or fruits or whole plant extracts of Chinese Trillium or Patricia genus medicinal materials and 60-85% ethanol elution parts O -α-L-rhamnopyranosyl (1→2)- O -β-D-Glucopyranoside, Diosgenin-3- O -α-L-rhamnopyranosyl (1→4)-[ O -α-L-rhamnopyranosyl (1→2)]- O -β-D-Glucopyranoside, Diosgenin-3- O -α-L-rhamnopyranosyl (1→4)- O -α-L-rhamnopyranosyl (1→4)-[ O -α-L-rhamnopyranosyl (1→2)]- O -β-D-glucopyranoside, (23s,24s,25s)-spirosta-5-ene-1β, 3β, 21,23, 24-pentahydroxy-1β- O -β-D-Apifuranosyl-(1→3)- O -α-L-rhamnopyranosyl-(1→2)-[ O -β-D-Xylopyranosyl (1→3)]- O -α-L-arabinopyranoside, (23s,24s,25s)-spirosta-5-ene-1β, 3β, 23, 24-tetrahydroxy-1β- O -β-D-Apifuranosyl-(1→3)- O -α-L-rhamnopyranosyl-(1→2)-[ O -β-D-Xylopyranosyl (1→3)]- O -α-L-arabinopyranoside, (23s,24s,25s)-spirosta-5-ene-1β, 3β, 21, 23, 24-pentahydroxy-1β- O -α-L-rhamnopyranosyl-(1→2)-[ O -β-D-Xylopyranosyl (1→3)]- O - The pre...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a preparation method of steroid saponin, sesquiterpenoid, phenylpropanoid glycoside and phenolic acid monomeric substances in Chinese Trillium tschonoskii Maxim. and rhizoma paridis medicinal materials and application of the monomeric substances to the preparation of medicine for treating Alzheimer disease. The monomeric substances are steroid saponin, sesquiterpenoid, phenylpropanoid glycoside and phenolic acid monomeric compounds obtained by separating, purifying and refining 30-85% ethanol elution parts of macroporous adsorption resin on the total extract of the roots and tubers, fruit or whole herb of Chinese Trillium tschonoskii Maxim. and rhizoma paridis, and the monomeric substances have biological activity on inhibiting Abeta fibril formation and stopping fibril aggregation. Due to the fact that the monomeric substances have common identical or similar mother-nucleus-structure units such as Pennogenin, Trillium tschonoskii Maxim. sapogenin, diosgenin, sterol sapogenin, furostan sapogenin and sesquiterpene aglycone, the monomeric substances have similar curative effect on the Alzheimer disease.

Description

technical field [0001] The invention relates to a preparation method of steroidal saponins, sesquiterpenoids, phenylpropanoid glycosides and phenolic acids in the roots, rhizomes or fruits of medicinal materials of the genus Trillium or Pachyphytum genus in China and their preparation methods. The application of the medicine for treating senile dementia and Alzheimer's disease belongs to the technical field of traditional Chinese medicine preparation. Background technique [0002] Alzheimer's Disease (AD) is a degenerative disease of the nervous system. The incidence rate of the elderly is high. The main clinical manifestations are memory loss, disorientation and impaired judgment and reasoning ability. Now it is more recognized that the classification of AD (that is, senile dementia) includes senile dementia, vascular dementia and mixed dementia. Senile plaques are the main pathological hallmark of AD, in which Aβ aggregation is the central link, a key factor in the pathog...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/896A61P25/28
CPCA61K36/896A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 张忠立左月明
Owner 张忠立
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap