Composition comprising a uridine source and an omega-3 PUFA for improving coordination, balance, grip strength or fine motor skills

A technology of uridine source and nutritional composition, applied to the composition of omega-3 polyunsaturated fatty acids, including the field of uridine source, capable of solving problems such as no specific disclosure

Inactive Publication Date: 2016-11-30
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even though reference is made to motor skills in which brain operations function, there is no specific disclosure of using specific combinations of components to provide compositions that are particularly useful for improving or maintaining limb functioning in mammals

Method used

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  • Composition comprising a uridine source and an omega-3 PUFA for improving coordination, balance, grip strength or fine motor skills
  • Composition comprising a uridine source and an omega-3 PUFA for improving coordination, balance, grip strength or fine motor skills
  • Composition comprising a uridine source and an omega-3 PUFA for improving coordination, balance, grip strength or fine motor skills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] Parkinson's disease (PD) was induced in mice by intrastriatal injection of 2.7 μg rotenone by stereotaxic surgery of the brain. Epidemiological studies have previously shown that exposure to this pesticide induces Parkinson's disease (PD). Rotating rod pedal spinners consist of a plastic rod with a non-slip surface on a base (walking board). The mice were placed on the accelerator rod, and the speed was gradually increased from 2 rpm to 20 rpm. The rodent's ability to remain on the rotarod (time to first fall) was recorded for a maximum of 5 minutes. Prior to baseline, mice were trained with the rotarod apparatus to rule out learning effects throughout the experiment.

[0129] Four experimental groups of 10 mice each were used, which were injected with rotenone or vehicle according to Table 1 and which received a control or active diet (=UMP+fish oil). Table 2 presents the specific composition of the control and active diets. Dietary interventions started one week b...

Embodiment 2

[0136] Ready-to-use liquid product, providing per 100mL:

[0137] Energy: 50-120kcal

[0138] Protein: 0-10g

[0139] Lipid: 1-5g

[0140] Digestible carbohydrates: 4-30g

[0141] and it contains:

[0142] DHA+EPA+DPA=1000-2000mg

[0143] Uridine monophosphate (disodium salt) or uridine 0.5g

Embodiment 3

[0145] A preferred daily dose of nutritional composition according to the invention or per 100 ml of composition comprises:

[0146] 100–500mg, preferably 200-400mg EPA,

[0147] 900–1500mg, preferably 950-1300mg DHA

[0148] 50–600 mg, preferably 60-200 mg phospholipids,

[0149] 200–600mg, preferably 300-500mg choline,

[0150] 400–800 mg, preferably 500–700 mg UMP or equimolar amounts of uridine,

[0151] 20–60 mg, preferably 30–50 mg vitamin E (α-TE),

[0152] 60–100mg, preferably 60-90mg vitamin C,

[0153] 40–80 μg, preferably 45-65 μg selenium,

[0154] 1–5 μg, preferably 2-4 μg vitamin B12,

[0155] 0.5–3 mg, preferably 0.5–2 mg vitamin B6, and

[0156] 200-600 μg, preferably 300-500 μg folic acid.

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PUM

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Abstract

Composition comprising a uridine source, an omega-3 PUFA for improving coordination, balance, grip strength or fine motor skills. The invention is directed to a combination of a uridine source and an omega-3-polyunsaturated fatty acid having 18-24 carbon atoms for use in - the prevention or treatment of a disturbance in coordination of limbs in a mammal, - the prevention or treatment of a disturbance in equilibrium in a mammal, - for use in the prevention or treatment of a disturbance in limb strength, - or use in the prevention or treatment of a disturbance in a motor skill in a mammal.

Description

technical field [0001] The present invention relates to compositions comprising a source of uridine, omega-3 polyunsaturated fatty acids for improving coordination, balance, grip strength or fine motor skills of a subject. Background technique [0002] The nervous system, specifically the brain, plays an important role in the life of mammals. For example cognitive, emotional, social, sensory, motor and regulatory functions are primarily determined by the brain. In society, an increasing number of diseases, disorders and problems are recognized as underlying the normal functioning of the brain. Brain functioning may be impaired, for example, due to trauma (eg, accident, violence), substance abuse (eg, alcohol), or systemic malnutrition. Also during aging, several deleterious changes occur in the nervous system, specifically the brain. Brain malfunction is therefore particularly problematic in the elderly, and those who are particularly frail or malnourished. Within this g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/10A61K45/06A61K31/14A61K31/202A61K31/355A61K31/375A61K31/4415A61K31/519A61K31/7068A61K31/7072A61K31/714A61K33/04A61P25/02A61P25/14A61P25/16
CPCA61K45/06A61K31/14A61K31/202A61K31/355A61K31/375A61K31/4415A61K31/519A61K31/7068A61K31/714A61K33/04A23L33/10A61K31/7072A61P1/10A61P25/02A61P25/14A61P25/16A61K2300/00A23L33/15A23V2002/00A61K31/683A23L33/12A23L33/175A61K9/0053A61K31/593A61K31/715A61K38/16
Inventor 阿莫斯·阿塔利
Owner NV NUTRICIA
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