Compound salviae miltiorrhizae effective component composition, preparation method and application thereof

An active ingredient, the technology of compound salvia miltiorrhiza, applied in the direction of medical preparations containing active ingredients, effective ingredients of hydroxyl compounds, organic active ingredients, etc., can solve problems such as ineffective therapeutic effects, achieve reliability and safety, and ensure controllable quality gender, modernization and internationalization

Inactive Publication Date: 2016-12-07
NANJING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there are many drugs on the market, the therapeutic effect is not obvious. Therefore, finding drugs that can restore the learning and memory function of the brain has very important clinical significance for improving the condition of AD patients.

Method used

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  • Compound salviae miltiorrhizae effective component composition, preparation method and application thereof
  • Compound salviae miltiorrhizae effective component composition, preparation method and application thereof
  • Compound salviae miltiorrhizae effective component composition, preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] 1. Pharmacological experiment

[0031] (1) compound salvia miltiorrhiza active ingredient composition is to AlCl 3 Study on spatial learning and memory ability of AD mice induced by D-galactose

[0032] All studies were approved by the Laboratory Animal Ethics Committee and followed the relevant requirements of the Laboratory Animal Ethics Guidelines. Use AlCl 3 and D-galactose by intraperitoneal injection of 10mg / kg AlCl 3 and 60mg / kg D-galactose for 90 days to construct the Alzheimer mouse model.

[0033] On this basis, the experimental mice in the model group, the huperzine A positive drug group, and the compound salvia miltiorrhiza active ingredient composition administration group were given intragastric administration for two weeks.

[0034] Thirty-two three-week-old male BALB / c mice (purchased from the Model Animal Research Institute of Nanjing University), weighing 16±2g, were randomly divided into 4 groups, labeled A, B, C and D, with 8 mice in each group ...

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Abstract

The invention belongs to the technical field of preparation of traditional Chinese medicines and particularly relates to a compound salviae miltiorrhizae effective component composition, a preparation method and an application thereof. The compound salviae miltiorrhizae effective component composition is composed of tanshinone IIA, notoginsenoside R1 and borneol according to different ratio. In the invention, traditional Chinese medicine is combined with modern scientific technologies, wherein the researching and development of the traditional Chinese medicine is based on standard of Western medicines and the medicine effect and chemical compounds are presented in a standardization manner. A modern traditional Chinese medicine being safe and stable and being controllable in quality is researched and developed. The composition has safety, effectiveness and quality controllability. The invention solves a problem of connection between traditional Chinese medicines and international medicine development tendency and has advantages on achievement of modernization and internalization of traditional Chinese medicine.

Description

1. Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation. Specifically relates to a compound salvia miltiorrhiza active ingredient composition and a preparation method and application thereof. 2. Background technology [0002] Alzheimer's Disease (AD) is a common neurodegenerative disease with a high incidence in the aging society, mainly characterized by the accumulation of neurofibrillary tangles (NFT), β-amyloid plaques, Neuronal loss and inflammation are pathological markers, and neurological dysfunction such as memory loss and cognitive impairment is the main manifestation. At present, there are about 6 million senile dementia patients in my country, and the prevalence rate is increasing year by year. It has become the fourth leading cause of death after heart disease, cancer and stroke. In 2050, it is estimated that there will be more than 100 million Alzheimer's patients worldwide. AD patients cannot fully t...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/58A61K31/045A61P25/28A61P9/10A61P15/00A61P29/00A61P19/02A61P25/20A61P1/16
CPCA61K31/045A61K31/58A61K31/704A61K2300/00
Inventor 杨洁
Owner NANJING UNIV
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