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Paeonol extracting method

An extraction method and paeonol technology are applied in the field of plant biology to achieve the effects of pure taste, improving extraction rate and facilitating absorption

Inactive Publication Date: 2017-01-25
李健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no research about the use of ethanol and CO 2 Method for preparing paeonol by supercritical fluid extraction

Method used

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  • Paeonol extracting method

Examples

Experimental program
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Effect test

Embodiment 1

[0020] see figure 1 , in the embodiment of the present invention, a kind of extraction method of paeonol, concrete steps are as follows:

[0021] (1) Take an appropriate amount of peony root bark and crush it, pass it through a 40-mesh sieve, use 3 times the weight of ethanol as the entrainer, and use CO 2 Supercritical extraction, the specific parameters are: extraction kettle temperature

[0022] (4) Extract the thick paste C with purified water for 6 times, cool the extract to 10°C, let it stand for 30 hours, filter, and condense it into an alcohol-free thick paste D within the range of 30°C to obtain Paeonol.

Embodiment 2

[0024] In an embodiment of the present invention, a method for extracting paeonol, the specific steps are as follows:

[0025] (1) Take an appropriate amount of peony root bark and crush it, pass through a 40-mesh sieve, use 4 times the weight of ethanol as the entrainer, and use CO 2 Supercritical extraction, the specific parameters are: extraction kettle temperature 68°C, extraction pressure 12MPa, flow rate 11L / h, extraction time 6 hours; first separation kettle: temperature 54℃, separation pressure 7MPa; second separation kettle: temperature 42℃, The separation pressure is 3.5MPa; the CO 2 Supercritical Extract A.

[0026] (2) The peony root bark CO in step (1) 2 The supercritical extract A is adsorbed by a macroporous adsorption resin, pre-washed with ethanol with a concentration of 13%, and then eluted with ethanol with a flow rate of 11L / h and a concentration of 60%, and the collected eluent is medicinal solution B;

[0027] (3) Concentrate liquid B at 62°C to obtain...

Embodiment 3

[0030] In an embodiment of the present invention, a method for extracting paeonol, the specific steps are as follows:

[0031] (1) Take an appropriate amount of peony root bark and crush it, pass it through a 40-mesh sieve, use 5 times by weight of ethanol as the entrainer, and use CO 2 Supercritical extraction, the specific parameters are: extraction kettle temperature 70°C, extraction pressure 13MPa, flow rate 12L / h, extraction time 6 hours; first separation kettle: temperature 54℃, separation pressure 7MPa; second separation kettle: temperature 42℃, Separation pressure 3MPa; prepared peony root bark CO 2 Supercritical Extract A;

[0032] (2) The peony root bark CO in step (1) 2 The supercritical extract A is adsorbed by a macroporous adsorption resin, pre-washed with ethanol with a concentration of 18%, and then eluted with ethanol with a flow rate of 10L / h and a concentration of 70%, and the collected eluent is medicinal solution B;

[0033] (3) Concentrate liquid B at ...

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Abstract

The invention discloses a paeonol extracting method which comprises the following steps: crushing peony roots and bark, screening with a 40-mesh sieve, taking 3-6 parts by weight of ethyl alcohol as an entrainer, implementing supercritical extraction with CO2 to prepare a peony root and bark CO2 supercritical extract A; adsorbing with macroporous resin, prewashing with ethyl alcohol at the concentration of 10-20%, eluting with ethyl alcohol at the concentration of 50-80% at the flow velocity of 10-12L / h, and collecting an eluent as a liquid B; concentrating at the temperature range of 60-65 DEG C to obtain a thick paste C; extracting with purified water for 5-6 times, cooling an extract solution to 0-10 DEG C, standing for 24-30 hours, filtering, and concentrating into an alcohol-free thick paste D at the temperature range of 25-30 DEG C, so as to obtain the paeonol. The paeonol is added into a medicinal additive to prepare a pharmaceutical preparation for curing and preventing cardiovascular diseases through a pharmaceutically acceptable preparation method. The extraction rate of the paeonol is increased, the time is shortened, the extracting temperature is lowered, employed reagents are non-toxic, natural active ingredients are kept, and the paeonol is favorable for absorption by a human body.

Description

technical field [0001] The invention relates to the field of plant biotechnology, in particular to a method for extracting paeonol. Background technique [0002] According to the Compendium of Materia Medica and the records of ancient prescriptions, peony has certain medicinal effects, and the root bark of peony is pungent, cold, and non-toxic; it has certain curative effects on hernia, women's bad blood, blood stasis due to injury, internal bleeding after knife wound, and sores on the lower part; and The roots, bark, flowers, leaves, branches and the extracted paeonol of peony are very good health food, and are very popular in domestic and international markets. [0003] Moutan root bark contains paeonol, paeoniflorin, gallic acid, volatile oil 0.15-0.4% phytozil, paeonol glycoside, gallic acid glucose, paeonol protoside, oxidized paeoniflorin, etc., so peony not only has high ornamental artistic value , and has good health, beauty and medicinal value. Flavonoids are subs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/84C07C45/78C07C45/79A61P9/00
CPCC07C45/78C07C45/79C07C49/84Y02P20/54
Inventor 李健
Owner 李健
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