Canine parvovirus strain CPV-YH and applications thereof
A technology of canine parvovirus and CPV-YH, which is applied in the field of microbiology, can solve the problems such as the decline of vaccine effect and cannot meet the demand, and achieve the effect of strong pathogenicity, wide application range and high titer
Active Publication Date: 2017-04-26
北京世纪元亨动物防疫技术有限公司
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Problems solved by technology
[0007] According to the objective problems in the field that the effect of the above-mentioned existing vaccines has declined and cannot meet the needs, and the urgent need to isolate new strains, the present invention provides a new canine parvovirus strain CPV-YH, and the virus strain in Use in the preparation of vaccines and virus diagnostic reagents
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0045] Example 1 The disease material (intestinal tissue) used to isolate the virulent canine parvovirus strain (CPV-YH) of the present invention is from a diseased dog in a certain pet hospital in Beijing;
Embodiment 1 and Embodiment 2
[0046] The A-72 cells used for inoculation in Example 1 and Example 2 are commercially available;
Embodiment 3
[0047] The canine parvovirus control strain CPV standard strain (HA titer is 1:2560) that embodiment 3 proliferative ability comparative experiment adopts comes from China Animal Disease Prevention and Control Center;
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Abstract
The invention provides a canine parvovirus strain CPV-YH and applications thereof, and belongs to the technical field of microbes. The preservation number of the provided canine parvovirus strain CPV-YH is CGMCC No.12990. The invention also provides applications of the canine parvovirus strain CPV-YH in the preparation of canine parvovirus vaccines and canine parvovirus diagnostic reagents. Based on the canine parvovirus strain CPV-YH, the invention also provides a vaccine composition for preventing and / or treating diseases caused by canine parvovirus and a reagent for detecting a canine parvovirus strain and / or diagnosing diseases caused by canine parvovirus. A novel content and direction are provided for the research on the variation of epidemic virus; a novel strain is provided for the canine parvovirus vaccine development; and a high quality raw material and choice are provided for the vaccine development.
Description
technical field [0001] The invention belongs to the technical field of microbes, and in particular relates to a canine parvovirus strain CPV-YH and an application thereof. Background technique [0002] Canine parvovirus disease (CPD), also known as canine infectious enteritis or canine viral enteritis, is an acute, contact and fatal infectious disease of dogs caused by canine parvovirus (CPV). Clinical manifestations are characterized by acute hemorrhagic enteritis and non-suppurative myocarditis. The disease can occur throughout the year, and dogs of different ages, sexes and breeds are susceptible, but it is more common in puppies. It is mainly characterized by acute onset, short course of disease, strong infectivity and high mortality. It is one of the most serious infectious diseases that harm the dog industry. [0003] In 1977, American scholars Eugster and Nairn first observed feline parvovirus-like particles in the feces of dogs suffering from hemorrhagic enteritis...
Claims
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Login to View More IPC IPC(8): C12N7/00C12N7/04A61K39/23A61P31/20C07K16/08G01N33/569C12Q1/70C12Q1/68
Inventor 孙明邓小雨张丽马永缨刘巧荣卢会英刘伯华杨欣艳陈西钊
Owner 北京世纪元亨动物防疫技术有限公司
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