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Application of serum molecular marker combination as lung cancer diagnosis and curative effect monitoring marker

A molecular marker and lung cancer diagnosis technology, applied in the field of immunodiagnosis, can solve the problems that are not enough for independent clinical application

Inactive Publication Date: 2017-05-17
南京弘泰德生物科技有限公司
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Problems solved by technology

However, OPN itself is not sufficient for clinical application alone

Method used

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  • Application of serum molecular marker combination as lung cancer diagnosis and curative effect monitoring marker
  • Application of serum molecular marker combination as lung cancer diagnosis and curative effect monitoring marker
  • Application of serum molecular marker combination as lung cancer diagnosis and curative effect monitoring marker

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Embodiment Construction

[0055] The present invention will be further described below in conjunction with the accompanying drawings.

[0056] Eleven candidate serum proteins are osteocalcin (OPN), serum amyloid (SAA), C-reactive protein (CRP), carcinoembryonic antigen (CEA), cytokeratin antigen 19 fragment (CYFRA21-1), macrophage Migration inhibitory factor (MIF), α1 acid glycoprotein (AGP), hepatocyte growth factor (HGF), E-selectin (E-selectin), growth-related oncogene (GRO), neuron-specific enolization enzyme (NSE). Eight serum protein molecular markers (OPN, SAA, CRP, CYFRA21.1, CEA, NSE, AGP and HGF) were significantly elevated in patients with non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Judging from the single protein level, OPN has a high diagnostic value for NSCLC (AUC=0.92), and CEA, CYFRA21.1, SAA and CRP also have good AUC values, and the AUC values ​​of CEA and CYFRA21.1 0.81 and 0.77, respectively, and the AUC of two acute phase proteins (SAA and CRP) was about...

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Abstract

The invention discloses application of a serum molecular marker combination as a lung cancer diagnosis and curative effect monitoring marker, belonging to the field of immunodetection. The content of protein (OPN, SAA, CRP, CEA, CYFRA21.1, MIF, AGP, HGF, E-selectin, GRO and NSE) in 11 serums is measured through a Luminex protein chip diagnosis technology. The eight serum protein molecular markers are OPN, SAA, CRP, CYFRA21.1, CEA, NSE, AGP and HGF. The eight serum protein molecular markers have significant promotion effect on a non-small cell lung cancer (NSCLC) and a small cell lung cancer (SCLC). A three-protein detection combination formed by OPN, CEA and another protein (CRP, SAA, CYFRA21.1 or NSE) has excellent diagnosis potential on NSCLC. Compared with the prior art, the serum molecular marker combination has the beneficial effects that the content of multiple protein molecular markers of serum of a patient with lung cancer is detected, and the serum molecular marker combination can be used for lung cancer diagnosis and curative effect monitoring through coordinated comparative analysis of the multiple protein molecular markers.

Description

technical field [0001] The present invention relates to the application of a combination of serum molecular markers as markers for lung cancer diagnosis and curative effect monitoring. The Luminex protein chip diagnostic technology is used to detect the contents of various protein molecular markers in the serum of lung cancer patients. Through the cooperation of various protein molecular markers The comparative analysis can be used for lung cancer diagnosis and curative effect monitoring, and belongs to the field of immunodiagnosis. [0002] technical background [0003] Cancer is one of the leading causes of death. With global population growth and aging, changes in lifestyle, and the impact of environmental climate, the burden of cancer will continue to increase. Cancer has always been a major problem facing the world . Lung cancer (LC) is one of the most common malignant tumors in the world. Clinically, it is generally divided into small cell lung cancer (SCLC) and non-sm...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/574
CPCG01N33/57423G01N33/57484G01N33/6893
Inventor 佘金雄顿博影吴建中徐恒
Owner 南京弘泰德生物科技有限公司
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