Application of 3-bromopyruvic acid in preparation of drug for treating pulmonary arterial hypertension
A technology of pulmonary hypertension and bromopyruvate, which is applied in drug combinations, active ingredients of anhydride/acid/halide, cardiovascular system diseases, etc., can solve problems such as poor efficacy, reduce pulmonary vascular remodeling, and increase cardiac output The effect of promoting apoptosis
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[0016] 1. Materials and methods
[0017] 1.1 Establishment of Rat Pulmonary Hypertension Model
[0018] Male SPF grade SD rats (provided by the animal room of Shanghai Chinese Academy of Sciences), weighing 200-220g. One-time subcutaneous injection of monocrotaline (Monocrotaline, MCT, 60mg / kg), 3 weeks later, right heart catheterization was used randomly to measure pulmonary artery pressure and hemodynamic parameters to identify whether the model was successfully established.
[0019] 1.2 Experimental grouping and drug intervention
[0020] (1) Model group (MCT group): 10 rats were given normal saline by intragastric administration after the pulmonary hypertension model was successfully established for 3 consecutive weeks.
[0021] (2) 3-bromopyruvate low-dose group (3-BrPA 15mg·kg·d group): 10 rats were given Tongxinluo by intragastric administration after the successful establishment of the pulmonary arterial hypertension model for 3 consecutive weeks.
[0022] (3) 3-bro...
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