Application of total glycosides of Cynanchum otophyllum Schneid to pharmacy

A technology of Qingyang ginseng, disease, applied in the field of traditional Chinese medicine

Inactive Publication Date: 2017-05-31
GUIZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of Qingyang ginseng in the treatment and prevention of chronic stress disorder and PTSD has not been reported.

Method used

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  • Application of total glycosides of Cynanchum otophyllum Schneid to pharmacy
  • Application of total glycosides of Cynanchum otophyllum Schneid to pharmacy
  • Application of total glycosides of Cynanchum otophyllum Schneid to pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 10 kg of wild Cyan ginseng root, crush it, extract it three times with 80% ethanol, combine the extracts, concentrate and recover the solvent. The concentrated solution was diluted with water, extracted three times with petroleum ether, and the aqueous layer was extracted three times with chloroform, and the chloroform fractions were combined. Chloroform was recovered to obtain 230 g of light yellow powder, with a yield of 2.3%. The obtained light yellow powder is the total glycosides of Qingyangshen, taking caudatin as the reference substance, referring to the drug standard (WS 3 -B-2343-97) method, the measured total glycoside content is 62.5%.

[0015] Both Lieberman-Burchard and Keller-Killiani reactions were positive, indicating that the total glycosides were steroidal compounds containing 2-deoxysugars.

Embodiment 2

[0017] Take 10 kg of cultivated Cyan ginseng root, crush it, extract it three times with 75% ethanol, combine the extracts, concentrate and recover the solvent. The concentrated solution was diluted with water, extracted three times with petroleum ether, and the aqueous layer was extracted three times with chloroform, and the chloroform fractions were combined. Chloroform was recovered to obtain 310 g of light yellow powder, with a yield of 3.1%. The obtained light yellow powder is the total glycosides of Qingyangshen, taking caudatin as the reference substance, referring to the drug standard (WS 3 -B-2343-97) method, the measured total glycoside content is 65.5%.

Embodiment 3

[0019] Mix 100g of total glycosides of Qingyang ginseng, 60g of starch, and 5g of dextrin evenly, add 10% starch slurry to make soft material, granulate with 14-mesh nylon screen, ventilate and dry at 60-70°C, granulate with 16-mesh sieve, add hard 1.5 g of magnesium fatty acid and 5 g of sodium carboxymethyl starch were mixed, pressed into 1000 tablets, and coated to obtain the required tablets, each containing 100 mg of total glucosides of Qingyangshen.

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Abstract

Total glycosides of Cynanchum otophyllum Schneid can improve rats' chronic social frustration stress and chronic unpredictable mild stress model animal's symptoms, can improve high arousal behaviors of model animals' posttraumatic stress disorder in rats, and can be used in preparation of a medicine for treating and preventing chronic affective disorder and posttraumatic stress disorder.

Description

technical field [0001] The present invention relates to a kind of medicinal composition, specifically, is the medicinal composition that is made of total glucoside of Qingyang shenyang as active component and its preparation is used for preventing and treating chronic stress disorder and post-traumatic stress disorder The application of medicine belongs to the technical field of traditional Chinese medicine. Background technique [0002] Stress, proposed by Canadian psychologist Hans Selye in the 1930s, is a series of adaptive responses to maintain internal balance when the body's homeostasis is threatened. Stress response refers to various biological, psychological, social, and behavioral changes in individuals caused by stressors, often referred to as psychosomatic responses to stress. These psychological stress sources include: serious life events, major disasters; long-term interpersonal tension, high work pressure and other life and work stresses; stresses caused by ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/27A61P25/28A61P25/00A61K125/00
CPCA61K36/27A61K9/2059A61K9/28A61K9/4866
Inventor 杨庆雄李勇辉高博李欣
Owner GUIZHOU NORMAL UNIVERSITY
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