Use of Radix Astragali or Radix Radix Radix Polysaccharides for the Treatment of Ischemic Vascular Diseases

Abstract

The invention relates to a purpose of radix hedysari or hedysarum polybotrys saccharide to treatment of ischemic vascular diseases. Particularly, on the basis of observing that the hedysarum polybotrys saccharide has the effect of promoting the primary generation blood vessel ring bud growth effect, the effect of the radix hedysari or hedysarum polybotrys saccharide for preventing and treating the ischemic vascular diseases is discovered. The invention further relates to a medicine composition containing the radix hedysari or hedysarum polybotrys saccharide for treating the ischemic vascular diseases.

Description

technical field

[0001] The present invention relates to the use of Radix Radix Radix Radix or Radix Radix Radix Radix Polysaccharide in the preparation of medicines for preventing and / or treating ischemic vascular diseases. The present invention further relates to a pharmaceutical composition containing astragalus or astragalus polysaccharide as an active ingredient. Background technique

[0002] Ischemic vascular disease has become one of the major diseases that threaten human health, mainly including ischemic cerebrovascular disease, ischemic cardiomyopathy and ischemic peripheral vascular disease, with high morbidity, high mortality, high residual rate, high recurrence rate and other characteristics. Ischemic vascular diseases often cause irreversible damage to tissues and blood vessels. Due to the interruption of blood flow and oxygen supply, their physiological functions or activities are significantly damaged, resulting in a series of complex pathophysiological proces...

Examples

Embodiment 1

[0037] The extraction preparation of embodiment 1 Radix Astragali polysaccharide

[0038] Grind the Radix Radix Radix, pass through a 200-mesh sieve, add 10, 8, and 6 times the amount of water to decoct 3 times, each time for 1 hour, filter, and collect the filtrate. After the filtrate is concentrated to 1:1, add absolute ethanol until the alcohol content reaches 20%, let stand, centrifuge, and discard the precipitate. Continue to add absolute ethanol until the alcohol content reaches 70%, let it stand for 24 hours, and filter with suction to obtain a precipitate, which is dried and weighed. Heat 10 times the amount of water to dissolve, filter while hot, add pepsin to the filtrate to degrade macromolecular protein, and then use Sevag method to remove protein (chloroform: amyl alcohol = 4:1 mixture) to obtain a solution. Recover the solution under reduced pressure to remove chloroform and amyl alcohol, add absolute ethanol until the alcohol content is 70%, let it stand for 24...

Embodiment 2

[0039] Embodiment 2 capsules

[0040] Mix 50g of Radix Polysaccharides with 280g of starch evenly, make granules with starch slurry (take 220g of starch and make starch slurry with water), sieve, dry, and pack into capsules.

Embodiment 3

[0041] Example 3 Tablet 1

[0042] Mix 80g of Radix Astragali polysaccharide and 340g of starch evenly, make granules with starch slurry (take 210g of starch to make starch slurry with water), sieve, dry, add 6% magnesium stearate, mix evenly, press into tablets, and coat with film. Can.

technical field

[0001] The present invention relates to the use of Radix Radix Radix Radix or Radix Radix Radix Radix Polysaccharide in the preparation of medicines for preventing and / or treating ischemic vascular diseases. The present invention further relates to a pharmaceutical composition containing astragalus or astragalus polysaccharide as an active ingredient. Background technique

[0002] Ischemic vascular disease has become one of the major diseases that threaten human health, mainly including ischemic cerebrovascular disease, ischemic cardiomyopathy and ischemic peripheral vascular disease, with high morbidity, high mortality, high residual rate, high recurrence rate and other characteristics. Ischemic vascular diseases often cause irreversible damage to tissues and blood vessels. Due to the interruption of blood flow and oxygen supply, their physiological functions or activities are significantly damaged, resulting in a series of complex pathophysiological proces...

Examples

Embodiment 1

[0037] The extraction preparation of embodiment 1 Radix Astragali polysaccharide

[0038] Grind the Radix Radix Radix, pass through a 200-mesh sieve, add 10, 8, and 6 times the amount of water to decoct 3 times, each time for 1 hour, filter, and collect the filtrate. After the filtrate is concentrated to 1:1, add absolute ethanol until the alcohol content reaches 20%, let stand, centrifuge, and discard the precipitate. Continue to add absolute ethanol until the alcohol content reaches 70%, let it stand for 24 hours, and filter with suction to obtain a precipitate, which is dried and weighed. Heat 10 times the amount of water to dissolve, filter while hot, add pepsin to the filtrate to degrade macromolecular protein, and then use Sevag method to remove protein (chloroform: amyl alcohol = 4:1 mixture) to obtain a solution. Recover the solution under reduced pressure to remove chloroform and amyl alcohol, add absolute ethanol until the alcohol content is 70%, let it stand for 24...

Embodiment 2

[0039] Embodiment 2 capsules

[0040] Mix 50g of Radix Polysaccharides with 280g of starch evenly, make granules with starch slurry (take 220g of starch and make starch slurry with water), sieve, dry, and pack into capsules.

Embodiment 3

[0041] Example 3 Tablet 1

[0042] Mix 80g of Radix Astragali polysaccharide and 340g of starch evenly, make granules with starch slurry (take 210g of starch to make starch slurry with water), sieve, dry, add 6% magnesium stearate, mix evenly, press into tablets, and coat with film. Can.

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