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New polyglycosides of tripterygium wilfordii with low toxicity, its preparation method and application

A technology of tripterygium glycosides and tripterygium, which is applied in the field of medicine to achieve the effects of improving the level of inflammation in the body, obvious therapeutic effect, and reduced toxicity

Active Publication Date: 2020-08-28
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, triptolide triol has not been popularized and applied in the field of medicine

Method used

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  • New polyglycosides of tripterygium wilfordii with low toxicity, its preparation method and application
  • New polyglycosides of tripterygium wilfordii with low toxicity, its preparation method and application
  • New polyglycosides of tripterygium wilfordii with low toxicity, its preparation method and application

Examples

Experimental program
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Embodiment Construction

[0042] The present invention will be described in further detail below by way of examples.

[0043] Commonly used reagents used in the following preparation examples are commercially available reagents, and the instruments used are:

[0044] Ultra-high performance liquid chromatography (Waters Acquity, Waters Company of the United States), a balance of one-thousandth (AL104-IC, METTLER TOLEDO, Switzerland), a balance of one-hundred-thousandth (AB135-S, METTLER TOLEDO, Switzerland), a pH meter (PHS-3C, Shanghai Jingke Instrument Co., Ltd.), magnetic stirrer (HS7, German IKA company), rotary thin film evaporator (RV 10basic V, German IKA company), desktop microcentrifuge (Microfuge16, American BACKMAN company), Full-wavelength microplate reader (1510, Thermo Fisher Scientific (China) Co., Ltd.), Thermo Scientific pipette gun, 1-10 μL, 10-100 μL, 100-1000 μL (Thermo Fisher Scientific.inc), protein vertical electrophoresis transfer Membrane system (Bio-Rad), automatic immunoassay...

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Abstract

The invention discloses a new polyglycoside of tripterygium wilfordii with low toxicity, which is obtained by chemically processing the polyglycoside of tripterygium wilfordii and adding triptolide triol. The invention also discloses the application of the new tripterygium wilfordii polyglycoside with low toxicity in medicine. The tripterygium wilfordii new polyglycoside of the present invention can effectively relieve nephrotic syndrome kidney pathological damage and proteinuria, improve body inflammation level, have obvious therapeutic effect on nephrotic syndrome, and have low toxicity and long-lasting effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a new polyglycoside of tripterygium wilfordii with low toxicity, a preparation method of the new polyglycoside of tripterygium wilfordii and its medical application. Background technique [0002] Tripterygium wilfordii Hook.f. is a group of mixed glycosides extracted from the roots, bark, and leaves of Tripterygium wilfordii Hook.f., and its main chemical components include diterpene lactones, alkaloids, and triterpenes, etc. . Pharmacological studies have proved that Tripterygium wilfordii has anti-inflammatory, immunosuppressive or immunoregulatory, anti-tumor effects, and is currently a hot research immunomodulator at home and abroad. It can be used to treat rheumatoid arthritis, primary glomerular nephropathy, and nephropathy. Syndrome, purple scar and lupus nephritis, lupus erythematosus, subacute and chronic severe hepatitis, chronic active hepatitis; can also be used for allergic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/37A61P13/12A61P29/00A61P19/02A61P1/16A61P9/14A61P17/00A61P17/06A61P19/08A61P37/02A61P19/04
CPCA61K36/37A61K2236/51A61K2236/333
Inventor 刘博毛炜刘旭生徐鹏韩晓东周文徐方方刘敬功李援朝杨祎琦邓金宝吴利兰吴云山陈伟英田瑞敏陆金健张玉琴
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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