Method for improving water resistance and flexibility of polyacrylic acid membranes by MPEGPLA (methoxy polyethylene glycol-polylactide) and poly(lactide-glycolide)

A technology of polyacrylic acid film and polyacrylic acid, which is applied in the field of polymer film preparation, can solve the problems of polyacrylic acid film, such as hydrophilic stiffness, lack of water resistance and flexibility, etc., to improve water resistance and flexibility, easy to grasp, and water resistance The effect of improving sex and flexibility

Inactive Publication Date: 2017-07-25
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Polyacrylic acid is a biomaterial with good biocompatibility and biodegradability. Polyacrylic acid film can be used as artificial skin, etc., but polyacrylic acid film is too hydrophilic and stiff, and lacks good water resistance. and flexibility, which limits its application to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Preparation of polyacrylic acid-MPEGPLA-poly(lactide-glycolide) double graft copolymer

[0015] 16.9 g of polyacrylic acid (molecular weight 85,000), 9.9 g of hydroxyl-terminated MPEGPLA (molecular weight of 2,700), and 9.9 g of hydroxyl-terminated poly(lactide-glycolide) monolauryl ether ( Molecular weight is 2700), add 367 ml dimethyl sulfoxide, then add 0.052 g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 29°C for 2 days, terminated the reaction, obtained the target product by filtration, dialysis, and drying;

[0016] 2) Preparation of polyacrylic acid film modified by MPEGPLA and poly(lactide-glycolide)

[0017] Add 10 grams of polyacrylic acid-MPEGPLA-poly(lactide-glycolide) double-graft copolymer and 37ml of dimethyl sulfoxide solvent into the dry reactor, and add 2% poly( Lactide-glycolide) monododecyl ether (molecular weight: 2700), under an inert atmosphere, stirred and mixed at 49°C for 50 minutes, formed a film by ca...

Embodiment 2

[0020] 1) Preparation of polyacrylic acid-MPEGPLA-poly(lactide-glycolide) double graft copolymer

[0021] 21 g of polyacrylic acid (molecular weight 87,000), 12.2 g of hydroxyl-terminated MPEGPLA (molecular weight of 2,800), and 12.2 g of hydroxyl-terminated poly(lactide-glycolide) monolauryl ether ( Molecular weight is 2800), add 454 ml dimethyl sulfoxide, then add 0.038 g N,N' - Diisopropylcarbodiimide, under an inert atmosphere, stirred and reacted at 31°C for 3 days, terminated the reaction, and obtained the target product by filtration, dialysis, and drying;

[0022] 2) Preparation of polyacrylic acid film modified by MPEGPLA and poly(lactide-glycolide)

[0023] Add 9.9 grams of polyacrylic acid-MPEGPLA-poly(lactide-glycolide) double-graft copolymer and 36ml of dimethyl sulfoxide solvent into the dry reactor, and add 3% poly( Lactide-glycolide) monododecyl ether (molecular weight: 2800), under an inert atmosphere, stirred and mixed at 50°C for 55 minutes, formed a film ...

Embodiment 3

[0026] 1) Preparation of polyacrylic acid-MPEGPLA-poly(lactide-glycolide) double graft copolymer

[0027] 22.5 g of polyacrylic acid (molecular weight 93000), 12.8 g of hydroxyl-terminated MPEGPLA (molecular weight of 2900) and 12.8 g of hydroxyl-terminated poly(lactide-glycolide) monolauryl ether ( Molecular weight is 2900), add 481 ml dimethyl sulfoxide, then add 0.059 g 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under inert atmosphere, stir and react at 33°C for 4 days , the reaction is terminated, and the target object is obtained by filtering, dialysis and drying;

[0028] 2) Preparation of polyacrylic acid film modified by MPEGPLA and poly(lactide-glycolide)

[0029] Add 9.5 grams of polyacrylic acid-MPEGPLA-poly(lactide-glycolide) double-graft copolymer and 35ml of dimethyl sulfoxide solvent in the drying reactor, and add 4% poly( Lactide-glycolide) monododecyl ether (molecular weight: 2900), under an inert atmosphere, stirred and mixed at 52°C for 60 minutes, fo...

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Abstract

The invention discloses a method for improving water resistance and flexibility of polyacrylic acid films by MPEGPLA (methoxy polyethylene glycol-polylactide) and poly(lactide-glycolide). The method includes steps: 1) synthesis of a polyacrylic acid-MPEGPLA-poly(lactide-glycolide) double-grafted copolymer, to be more specific, adding hydroxyl-terminated MPEGPLA, hydroxyl-terminated poly(lactide-glycolide), monododecyl ether, solvent, a condensing agent and polyacrylic acid into a dry reactor, performing reaction for 2-3 days, and terminating reaction to obtain a target product; 2) preparation of an MPEGPLA and poly(lactide-glycolide) modified polyacrylic acid films, to be more specific, adding the polyacrylic acid-MPEGPLA-poly(lactide-glycolide) double-grafted copolymer, poly(lactide-glycolide) monododecyl ether and solvent into the dry reactor, mixing for 50-60min, adopting a film casting method for film formation, and drying to obtain a target product. The method is simple in preparation process and easy to master, and water resistance and flexibility of the modified films are greatly improved.

Description

technical field [0001] The invention relates to a method for improving the water resistance and flexibility of polyacrylic acid films, and belongs to the technical field of polymer film preparation. Background technique [0002] Polyacrylic acid is a biomaterial with good biocompatibility and biodegradability. Polyacrylic acid film can be used as artificial skin, etc., but polyacrylic acid film is too hydrophilic and stiff, and lacks good water resistance. and flexibility, which limits its application to a certain extent. MPEGPLA (polyethylene glycol to polylactic acid in a weight ratio of 10 / 90) and poly(D,L-lactide-glycolide) (lactide to glycolide in a weight ratio of 90 / 10) are Excellent biocompatibility and biodegradability of biomaterials, with good hydrophobicity and flexibility. First, the MPEGPLA segment and the poly(lactide-glycolide) segment were simultaneously introduced into the polyacrylic acid segment to form a polyacrylic acid-MPEGPLA-poly(lactide-glycolide)...

Claims

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Application Information

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IPC IPC(8): C08L87/00C08L67/04C08J5/18C08G81/02
CPCC08L87/005C08G81/027C08J5/18C08J2387/00C08J2467/04C08L2203/16C08L67/04
Inventor林治涛朱国全
OwnerSHANDONG UNIV OF TECH