Method used for improving water resistance and flexibility of polyacrylic acid film with poly (p-dioxanone) and poly(lactic-co-glycolic acid)

A technology of polydioxanone and polylactic acid glycolic acid, which is applied in the field of polymer film preparation, can solve the problems of polyacrylic acid membranes such as hydrophilic stiffness, lack of water resistance and flexibility, and improve water resistance and flexibility Improvement of durability, ease of handling, water resistance and flexibility

Inactive Publication Date: 2017-07-28
SHANDONG UNIV OF TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Polyacrylic acid is a biomaterial with good biocompatibility and biodegradability. Polyacrylic acid film can be used as artificial skin, etc., but polyacrylic acid film is too hydrophilic and stiff, and lacks good water resistance. and flexibility, which limits its application to a certain extent

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Preparation of polyacrylic acid-polydioxanone-poly(lactic-co-glycolic acid) double graft copolymer

[0015] 16.8 grams of polyacrylic acid (molecular weight 84000), 9.5 grams of hydroxyl-terminated polydioxanone monolauryl ether (molecular weight of 2600) and 9.5 grams of hydroxyl-terminated poly(lactic-co-glycolic acid) were added to the dry reactor. tridecyl ether (molecular weight 2600), add 358 ml dimethyl sulfoxide, then add 0.052 g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 28°C for 2 days, terminated the reaction, obtained the target product by filtration, dialysis, and drying;

[0016] 2) Preparation of polyacrylic acid film modified by polydioxanone and poly(lactic-co-glycolic acid)

[0017] Add 10 grams of polyacrylic acid-polydioxanone-poly(lactic-co-glycolic acid) double-graft copolymer and 37 ml of dimethyl sulfoxide solvent into the dry reactor, and add 2% of the total weight of the modified membrane in addition. ...

Embodiment 2

[0020] 1) Preparation of polyacrylic acid-polydioxanone-poly(lactic-co-glycolic acid) double graft copolymer

[0021] 20.7 g of polyacrylic acid (molecular weight 87000), 11.6 g of hydroxyl-terminated polydioxanone monolauryl ether (molecular weight of 2700) and 11.6 g of hydroxyl-terminated poly(lactic-co-glycolic acid) were added to the dry reactor. tridecyl ether (molecular weight 2700), add 439 ml dimethyl sulfoxide, then add 0.038 g N,N' -Diisopropylcarbodiimide, stirred and reacted at 30°C for 3 days under an inert atmosphere, terminated the reaction, and obtained the target product by filtration, dialysis, and drying;

[0022] 2) Preparation of polyacrylic acid film modified by polydioxanone and poly(lactic-co-glycolic acid)

[0023] Add 9.9 grams of polyacrylic acid-polydioxanone-polylactic-co-glycolic acid double-graft copolymer and 36 ml of dimethyl sulfoxide solvent into the drying reactor, and add 2% of the total weight of the modified membrane in addition. Tride...

Embodiment 3

[0026] 1) Preparation of polyacrylic acid-polydioxanone-poly(lactic-co-glycolic acid) double graft copolymer

[0027] 22 grams of polyacrylic acid (molecular weight: 91,000), 12.5 grams of hydroxyl-terminated polydioxanone monolauryl ether (molecular weight: 2,800) and 12.5 grams of hydroxyl-terminated poly(lactic-co-glycolic acid) were added to the dry reactor. Tridecyl ether (molecular weight: 2800), add 471 ml dimethyl sulfoxide, then add 0.058 g 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under inert atmosphere, in The reaction was stirred at 32°C for 2 days, the reaction was terminated, and the target product was obtained by filtration, dialysis, and drying;

[0028] 2) Preparation of polyacrylic acid film modified by polydioxanone and poly(lactic-co-glycolic acid)

[0029] Add 9.5 grams of polyacrylic acid-polydioxanone-poly(lactic-co-glycolic acid) double-graft copolymer and 35 ml of dimethyl sulfoxide solvent in the drying reactor, and add 3% of the total weight o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method used for improving water resistance and flexibility of polyacrylic acid film with poly (p-dioxanone) and poly(lactic-co-glycolic acid). The method comprises following steps: 1, synthesis of a polyacrylic acid-poly (p-dioxanone)-poly(lactic-co-glycolic acid) double grafted copolymer, wherein hydroxyl-terminated poly (p-dioxanone) monododecyl ether, hydroxyl-terminated poly(lactic-co-glycolic acid) monotridecyl ether, a solvent, a condensing agent, and polyacrylic acid are delivered into a dried reactor, and reaction is carried out for 2 to 3 days so as to obtain an object product; 2, preparation of the poly (p-dioxanone) and poly(lactic-co-glycolic acid) modified polyacrylic acid film, wherein the polyacrylic acid-poly (p-dioxanone)-poly(lactic-co-glycolic acid) double grafted copolymer, poly(lactic-co-glycolic acid) monotridecyl ether, and the solvent are delivered into the dried reactor, mixing is carried out for 50 to 60min, and film forming and drying are carried out so as to obtain a target product. The method is simple and convenient; and the water resistance and the flexibility of the obtained polyacrylic acid film are improved greatly.

Description

technical field [0001] The invention relates to a method for improving the water resistance and flexibility of polyacrylic acid films, and belongs to the technical field of polymer film preparation. Background technique [0002] Polyacrylic acid is a biomaterial with good biocompatibility and biodegradability. Polyacrylic acid film can be used as artificial skin, etc., but polyacrylic acid film is too hydrophilic and stiff, and lacks good water resistance. and flexibility, which limits its application to a certain extent. Polydioxanone and poly(D,L) lactic acid glycolic acid (the molar ratio of lactic acid to glycolic acid is 90 / 10) are biomaterials with excellent biocompatibility and biodegradability, good hydrophobic and flexibility. Firstly, the polydioxanone segment and the poly(lactic-co-glycolic acid) segment were simultaneously introduced into the polyacrylic acid segment to form a polyacrylic acid-polydioxanone-poly(lactic-co-glycolic acid) double graft copolymer, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08L87/00C08L67/04C08J5/18C08G81/02
CPCC08L87/005C08G81/025C08G2230/00C08J5/18C08J2387/00C08J2467/04C08L2201/06C08L2203/16C08L67/04
Inventor林治涛朱国全
OwnerSHANDONG UNIV OF TECH