Method for improving water resistance and flexibility of polyacrylic acid membrane with MPEGPLA and poly(p-dioxanone)

A technology of polydioxanone and polyacrylic acid film, which is applied in the field of polymer film preparation, can solve the problems of polyacrylic acid film, such as hydrophilic stiffness, lack of water resistance and flexibility, and improve water resistance and flexibility , Easy to hold, water resistance and flexibility improvement effect

Inactive Publication Date: 2017-08-18
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Polyacrylic acid is a biomaterial with good biocompatibility and biodegradability. Polyacrylic acid film can be used as artificial skin, etc., but polyacrylic acid film is too hydrophilic and stiff, and lacks good water resistance. and flexibility, which limits its application to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Preparation of polyacrylic acid-MPEGPLA-polydioxanone double graft copolymer

[0015] 16.6 grams of polyacrylic acid (molecular weight 83000), 9.8 grams of hydroxyl-terminated MPEGPLA (molecular weight of 2600) and 9.8 grams of hydroxyl-terminated polydioxanone monolauryl ether (molecular weight of 2600) were added to the dry reactor. ), add 362ml dimethyl sulfoxide, then add 0.052g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 28°C for 2 days, terminated the reaction, obtained the target product by filtration, dialysis, and drying;

[0016] 2) Preparation of polyacrylic acid film modified by MPEGPLA and polydioxanone

[0017] Add 10 grams of polyacrylic acid-MPEGPLA-polydioxanone double-graft copolymer and 37 ml of dimethyl sulfoxide solvent into the dry reactor, and add 2% of the total weight of the modified membrane in addition. Cyclohexanone monododecyl ether (molecular weight: 2600), stirred and mixed at 47°C for 50 minutes ...

Embodiment 2

[0020] 1) Preparation of polyacrylic acid-MPEGPLA-polydioxanone double graft copolymer

[0021] 21 grams of polyacrylic acid (molecular weight 87000), 11.8 grams of hydroxyl-terminated MPEGPLA (molecular weight of 2700) and 11.8 grams of hydroxyl-terminated polydioxanone monolauryl ether (molecular weight of 2700) were added to the dry reactor. ), add 446ml dimethyl sulfoxide, then add 0.038g N,N' -Diisopropylcarbodiimide, stirred and reacted at 30°C for 3 days under an inert atmosphere, terminated the reaction, and obtained the target product by filtration, dialysis, and drying;

[0022] 2) Preparation of polyacrylic acid film modified by MPEGPLA and polydioxanone

[0023] Add 9.9 grams of polyacrylic acid-MPEGPLA-polydioxanone double-graft copolymer and 36 ml of dimethyl sulfoxide solvent into the dry reactor, and add 3% of the total weight of the modified membrane in addition. Cyclohexanone monododecyl ether (molecular weight: 2700), stirred and mixed at 49°C for 55 minut...

Embodiment 3

[0026] 1) Preparation of polyacrylic acid-MPEGPLA-polydioxanone double graft copolymer

[0027] 22.6 grams of polyacrylic acid (molecular weight 93000), 12.5 grams of hydroxyl-terminated MPEGPLA (molecular weight of 2800) and 12.5 grams of hydroxyl-terminated polydioxanone monolauryl ether (molecular weight of 2800) were added to the dry reactor. ), add 476 ml dimethyl sulfoxide, then add 0.059 g 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under inert atmosphere, stir the reaction at 34°C for 4 days, and terminate the reaction , by filtering, dialysis and drying, the target object is obtained;

[0028] 2) Preparation of polyacrylic acid film modified by MPEGPLA and polydioxanone

[0029] Add 9.5 grams of polyacrylic acid-MPEGPLA-polydioxanone double-graft copolymer and 35 ml of dimethyl sulfoxide solvent into the dry reactor, and add 4% of the total weight of the modified membrane in addition. Cyclohexanone monododecyl ether (molecular weight: 2800), stirred and mixed at...

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Abstract

The invention discloses a method for improving water resistance and flexibility of polyacrylic acid membrane with MPEGPLA and poly(p-dioxanone). The method comprises the following steps: 1) synthesis of a polyacrylic acid-MPEGPLA-poly(p-dioxanone) double graft copolymer: adding hydroxyl-capped MPEGPLA, hydroxyl-capped poly(p-dioxanone) mono-lauryl ether, a solvent, a condensing agent and polyacrylic acid into a drying reactor, stirring the mixture for reaction for 2-4 days and terminating the reaction, so as to obtain a target object; 2) preparation of an MPEGPLA-poly(p-dioxanone) modified polyacrylic acid membrane: adding the a polyacrylic acid-MPEGPLA-poly(p-dioxanone) double graft copolymer, poly(p-dioxanone) mono-lauryl ether and a solvent, stirring and mixing the mixture for 50-60min, forming a membrane with a flow casting method and drying the membrane, so as to obtain a target object disclosed by the invention. The method has the advantages that the preparation processes are simple and are mastered easily, and the water resistance and flexibility of the modified membrane are greatly improved.

Description

technical field [0001] The invention relates to a method for improving the water resistance and flexibility of polyacrylic acid films, and belongs to the technical field of polymer film preparation. Background technique [0002] Polyacrylic acid is a biomaterial with good biocompatibility and biodegradability. Polyacrylic acid film can be used as artificial skin, etc., but polyacrylic acid film is too hydrophilic and stiff, and lacks good water resistance. and flexibility, which limits its application to a certain extent. MPEGPLA (weight ratio of polyethylene glycol to polylactic acid is 10 / 90) and polydioxanone are biomaterials with excellent biocompatibility and biodegradability, good hydrophobicity and flexibility . First, the MPEGPLA segment and the polydioxanone segment are simultaneously introduced into the polyacrylic acid segment to form a polyacrylic acid-MPEGPLA-polydioxanone double graft copolymer, and then the polydioxanone The polyacrylic acid-MPEGPLA-polydio...

Claims

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Application Information

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IPC IPC(8): C08L87/00C08L67/04C08J5/18C08G81/02
CPCC08L87/005C08G81/025C08G81/027C08J5/18C08J2387/00C08J2467/04C08L2203/16C08L67/04
Inventor林治涛朱国全
OwnerSHANDONG UNIV OF TECH