Gene chip for hereditary leukoencephalopathy and its application

Abstract

The invention discloses a genetic leukoencephalopathy gene chip which comprises a probe aiming at following genes: MCC1, AMACR, PEX1, GALC, GCDH, PANK2, PLA2G6, ARSA and ABCD1. In one embodiment, the sequence of the probe is SEQ ID NO.1-74. The gene chip can realize gene detection of genetic leukoencephalopathy.

Description

technical field [0001] The invention belongs to the field of genetic disease detection, in particular to the detection of hereditary leukoencephalopathy, in particular to a gene chip for hereditary leukoencephalopathy and its application. Background technique [0002] Hereditary leukoencephalopathy, also known as leukodystrophy, refers to a group of progressive genetic diseases that mainly involve the white matter of the central nervous system. The clinical features of white matter lesions mainly include audiovisual impairment (involvement of long tracts), movement disorders, positive pyramidal tract signs, mental retardation or regression, and convulsions are rare or occur late in the course of the disease. [0003] Although these diseases currently lack a radical treatment, and most of them will eventually become disabled or even lead to early death, due to the establishment of molecular genetic diagnosis, most of these diseases can be predicted at present, that is, prenat...

AI Technical Summary

Problems solved by technology

The high cost of sequencing caused by huge data volume requirements has limited the application of whole genome sequencing to the genetic diagnosis of inherited metabolic diseases

Whole genome sequencing needs to generate a large amount of sequencing data, and the cost of sequencing is high, so the sequencing depth is unlikely to be too deep

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