Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Tanshinone IIA serving as human neuroastrocytoma resistant drug

A technology of astrocytes and tanshinone, applied in the field of medical and health care, can solve the problems of human astrocytoma surgery injury, short survival time, poor radiotherapy/chemotherapy effect, etc.

Inactive Publication Date: 2017-08-25
ZUNYI NO 1 PEOPLES HOSPITAL
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the technical problems of human astrocytoma treated by Western medicine in the prior art, such as surgical injury, poor radiotherapy / chemotherapy effect, and short survival time after treatment, the present invention provides tanshinone IIA as an anti-astroglioma drug The application of this method can greatly improve the inhibitory effect of astrocytoma, improve the effective rate of treatment and cure rate of patients, prolong the survival time of patients, and reduce the recurrence rate after cure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Tanshinone IIA serving as human neuroastrocytoma resistant drug
  • Application of Tanshinone IIA serving as human neuroastrocytoma resistant drug
  • Application of Tanshinone IIA serving as human neuroastrocytoma resistant drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] Below in conjunction with accompanying drawing, the present invention will be further described:

[0019] The application of tanshinone ⅡA as an anti-human astrocytoma drug is characterized in that: the main component of the anti-human astrocytoma drug is tanshinone ⅡA.

[0020] Further, the anti-human astrocytoma drug belongs to the prescription of effective extracts of traditional Chinese medicine, and the ingredients of the prescription include tanshinone IIA, matrine, and total extract of red ginseng.

[0021] Matrine is a kind of alkaloid extracted from Sophora flavescens of leguminous family. It is mainly oxymatrine and contains a small amount of oxymatrine. Oxymatrine is the main active ingredient in the whitening effect of matrine. It has the effects of clearing heat and dampness, diuresis and detoxification, improving symptoms and signs of hepatitis, reducing jaundice, and reducing enzymes. It can inhibit the replication of hepatitis B virus, induce endogenou...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of Tanshinone IIA serving as a human neuroastrocytoma resistant drug and relates to the field of medical sanitation. A principle component of the drug is Tanshinone IIA. Due to the in-vitro experiments for inhibiting growth of human neuroastrocytoma U251 and rat neuroastrocytoma C6, after the Tanshinone IIA acts on U-118MG cells, the survival rate of the U-118MG cells is gradually reduced along with increase of the concentration of the Tanshinone IIA and the prolonged action time. After the action time of the Tanshinone IIA reaches 48 hours, expression of Caspase 3 mRNA and proteins in the U-118MG cells is higher than that of negative control; the apoptosis rates of Tanshinone IIA groups with the concentrations of 10uM, 30uM and 100uM are respectively (9.8+ / -1.8)%, (16.5+ / -2.1)% and (23.2+ / -2.8)% and are all higher than (2.8+ / -1.1)% (P is less than 0.05) in the negative control. The experiments prove that the Tanshinone IIA serving as the human neuroastrocytoma resistant drug has clear effects and has an excellent effect of inhibiting the human neuroastrocytoma.

Description

technical field [0001] The invention relates to the medical and health field, in particular to the application of tanshinone IIA as an astrocytoma drug applicable to human body. Background technique [0002] In recent years, with various internal and external factors such as high work pressure, environment, and food, the number of cancer patients has been showing a rapid growth trend. Existing treatment methods mostly use surgical resection and radiotherapy / chemotherapy for postoperative intervention until the tumor cells are killed. However, surgery does great damage to the human body, and the process of radiotherapy / chemotherapy will not only kill tumor cells, but also kill tumor cells. The healthy cells of the human body are killed, so that the patient's constitution is weakened and the immunity is reduced. Most of the tumor cells in the patient's body will resurface. Therefore, there are great hidden dangers in the treatment of tumors with pure Western medicine, and the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/58A61K36/258A61P35/00A61K31/4375
CPCA61K31/4375A61K31/58A61K36/258A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 罗勇冯飞戴支凯杨小艳侯化化李园园施尚鹏马庆庆
Owner ZUNYI NO 1 PEOPLES HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com