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Application of echinacea extract to preparation of drug for preventing and treating senile dementia

A technology of Echinacea purpurea extract, Echinacea purpurea, applied in the field of medicine

Inactive Publication Date: 2017-10-24
南京惠宝生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The alcohol extract of Echinacea purpurea contains active ingredients such as echinacea, polyphenols, and cichoric acid, but no effective components of Echinacea purpurea have been used in the treatment of dementia.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 ： Preparation technology of Echinacea purpurea extract

[0030] Wash the whole herb of Echinacea purpurea, dry it, crush it, pass through a 80-mesh sieve, and make a coarse powder; use 15 times the amount of 45% ethanol for the coarse powder of Echinacea purpurea, soak it for 30 minutes, then use 45°C ethanol to reflux and extract 3 times, each time for 2 hours, and extract Filter and combine the filtrate; the filtrate is adsorbed by AB-8 macroporous resin column, then washed with deionized water until the effluent is colorless and then eluted with 50% ethanol solution; the eluate after the purification of the macroporous resin is combined and concentrated to the original volume 1 / 10 of that, recovered ethanol, adjusted the pH value of the solution to 3 with hydrochloric acid and 5% NAOH, extracted 4 times with ethyl acetate, collected the extract, concentrated it with a rotary evaporator, and evaporated to dryness under vacuum at 60°C to obtain Echinacea pu...

Embodiment 2

[0031] Example 2 : In vivo study proves that Echinacea purpurea extract has therapeutic effect on APP / PS1 double transgenic dementia mice

[0032] 1 material

[0033] 1.1 Experimental animals

[0034] Forty-eight 5-month-old APP / PS1 double transgenic mice, male, weighing 25±2g, SPF grade, and 8 C57BL / 6J mice with the same genetic background were normal controls.

[0035] 1.2 Experimental drugs and reagents

[0036] The positive control drug is donepezil hydrochloride (trade name: Aricept), 5 mg / tablet, the tablet is ground into powder before use, and double-distilled water is used to make a drug solution for oral administration of 0.65 mg / kg d - 1 ; Huperzine A Capsules were prepared with double distilled water to make a drug solution for gastric administration, and the prepared concentration was 0.026mg / kg·d - 1 . Acetylcholinesterase (AChE) kit, choline acetyltransferase (ChAT) kit, SOD activity kit, MDA content kit, GSH content kit. The following "Chi...

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PUM

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Abstract

The invention relates to preparation and application of an echinacea extract, in particular to the application of the echinacea extract to the preparation of a drug for preventing and treating senile dementia. The echinacea extract mainly comprises plant polyphenol and chicoric acid, and the content of the plant polyphenol and chicoric acid is not smaller than 60 percent. Experiment research shows that echinacea effective components can prevent A Beta 25-35 from damaging SH-SY5Y cells, improve the survival rate of the SH-SY5Y cells and improve the learning and memory ability of APP / PS1 double transgenic dementia mice. The extract can be used for preventing and treating one or more of alzheimer disease, vascular dementia and mixed dementia of alzheimer disease and vascular dementia.

Description

technical field [0001] The invention relates to a preparation method and application of an echinacea extract, in particular to an application of the echinacea extract in preparing medicines or health care products for preventing and treating senile dementia, which belongs to the field of medicine. Background technique [0002] With the increasing aging of the world's population, many diseases related to aging, such as senile dementia, have become factors that seriously threaten the health of the elderly in today's society, and the incidence of senile dementia is on the rise. Senile dementia mainly includes Alzheimer's disease (AD) and vascular dementia (VD). Alzheimer's disease accounts for about 60-70%, and vascular dementia accounts for about 20-30%. [0003] Alzheimer's disease (AD) is a degenerative disease of the central nervous system mainly characterized by progressive dementia. Its clinical features are memory and other cognitive dysfunction, and early clinical symp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P25/28A23L33/00A23L33/10
CPCA23V2002/00A61K36/28A23V2200/30A23V2250/21
Inventor 不公告发明人
Owner 南京惠宝生物医药有限公司
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