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Berchemia lineata (L.) DC. extract and application thereof in infantile cough treatment

A technology of extraction and reflux extraction, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, drug combinations, etc., can solve the problem that there is no literature disclosing the pharmacological activity of Neem or its extracts, etc. Achieve significant curative effect, relieve cough symptoms, and improve bioavailability

Inactive Publication Date: 2017-11-28
王彩兰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] By searching the domestic and foreign literature, there is no literature disclosing that Neem or its extract has pharmacological activity in treating cough

Method used

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  • Berchemia lineata (L.) DC. extract and application thereof in infantile cough treatment
  • Berchemia lineata (L.) DC. extract and application thereof in infantile cough treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the preparation of neem extract

[0024] (1) Weigh 50g of dried neem raw material, pulverize it, put it in a flask, add 800mL of 75% (V / V) ethanol solution, seal it, heat and reflux in a water bath at 85°C for 5h, filter, repeat the extraction once, and combine The filtrate, the filtrate was rotary evaporated under reduced pressure until there was no alcohol smell, and the concentrated neem extract was obtained. The concentrated solution was put into an oven, and the oven was set at 60°C, and dried to constant weight to obtain a dry extract 4.96 g, standby;

[0025] (2) Put 4.96 g of the obtained dry extract into a beaker, add 200 mL of anhydrous methanol and stir to dissolve it, adjust the pH to 4.7 with 6 mol / L concentrated hydrochloric acid, heat and reflux in a water bath at 70°C for 4 hours, and cool to room temperature in a natural environment , filtered to obtain the lower precipitate, put it into an oven, set the oven at 60° C., and dry to constan...

Embodiment 2

[0026] Embodiment 2: the preparation of Chinese neem extract (step 2 collects filtrate)

[0027] (1) Preparation of dry extract of Neem extract: Weigh 50g of dried Neem raw material, pulverize it, put it in a flask, add 800mL of 75% (V / V) ethanol solution, seal it, and heat to reflux in a water bath at 85°C Extract for 5 hours, filter, repeat the extraction once, combine the filtrates, and rotate the filtrates under reduced pressure to evaporate until there is no alcohol smell, to obtain a concentrated extract of Neem wuli, put this concentrated solution in an oven, and the oven is set at 60°C. Dried to constant weight to obtain 4.96g of dry extract, set aside;

[0028] (2) Put 4.96 g of the obtained dry extract into a beaker, add 200 mL of anhydrous methanol and stir to dissolve it, adjust the pH to 4.7 with 6 mol / L concentrated hydrochloric acid, heat and reflux in a water bath at 70°C for 4 hours, and cool to room temperature in a natural environment , filtered, and the fi...

Embodiment 3

[0029] Example 3: Preparation of Neem extract (using ethanol instead of methanol to dissolve the dry extract)

[0030](1) Weigh 50g of dried neem raw material, pulverize it, put it in a flask, add 800mL of 75% (V / V) ethanol solution, seal it, heat and reflux in a water bath at 85°C for 5h, filter, repeat the extraction once, and combine The filtrate, the filtrate was rotary evaporated under reduced pressure until there was no alcohol smell, and the concentrated neem extract was obtained. The concentrated solution was put into an oven, and the oven was set at 60°C, and dried to constant weight to obtain a dry extract 5.04 g, standby;

[0031] (2) Put 5.04 g of the obtained dry extract into a beaker, add 200 mL of absolute ethanol and stir to dissolve it, adjust the pH to 4.7 with 6 mol / L concentrated hydrochloric acid, heat and reflux in a water bath at 70°C for 4 hours, and cool to room temperature in a natural environment , filtered to obtain the lower precipitate, put it in...

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Abstract

The invention provides a Berchemia lineata (L.) DC. extract and application thereof in infantile cough treatment. Effective parts and / or effective components can be extracted and separated from Berchemia lineata (L.) DC. to the largest extent, and impurities are removed. The curative effect of the Berchemia lineata (L.) DC. extract for infantile cough treatment is significant, cough symptoms are rapidly relieved, the cough symptoms of most children are obviously relieved after taking the Berchemia lineata (L.) DC. extract for one day, the toxic and side effects are small, and the Berchemia lineata (L.) DC. extract is especially suitable for infantile cough treatment.

Description

technical field [0001] The invention belongs to the technical field of extracting natural active ingredients, and in particular relates to a neem extract and its application in treating children with cough. Background technique [0002] As an important reflex protection mechanism, coughing can remove sputum or foreign matter in the respiratory tract, keep the respiratory tract clean and unobstructed, and prevent the formation of infection. Therefore, for mild and infrequent cough, as long as the sputum or foreign matter is removed, it can be relieved spontaneously, and there is no need to apply cough medicine. However, if the cough is severe and persists, it will not only aggravate the pain of the patient, affect rest and sleep, increase physical exertion, and even promote the development of the disease and produce other complications. Therefore, appropriate cough medicine should be used at the appropriate time to relieve the cough. [0003] There are many kinds of existin...

Claims

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Application Information

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IPC IPC(8): A61K36/72A61K9/16A61K47/32A61K47/26A61P11/14
CPCA61K9/1623A61K9/1635A61K36/72A61K2236/333A61K2236/51
Inventor 李晶王彩兰
Owner 王彩兰
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