Concentration device for production of simvastatin

Abstract

The invention discloses a concentration device for production of simvastatin. The device includes a concentration tank, the outer wall at the bottom of the concentration tank is sleeved with a heating jacket, one side top of the concentration tank is connected to a feed pipe through a flange, one side bottom of the concentration tank is connected to an electronic liquid level meter by a flange, one side of the inner wall at the bottom of the concentration tank is connected to an electronic thermometer through a bolt, the bottom of the concentration tank is connected to a concentrated liquid electromagnetic valve through a flange, the outlet of the concentrated liquid electromagnetic valve is connected to a concentrated liquid transfer pump through a pipeline, and the top of the concentration tank is connected to a gas-liquid separator through a pipeline. According to the invention, both the concentration tank and the heating jacket are coated with a thermal insulation layer, at the same time the mixed liquid returned by a liquid return pump is heated by a heater, and then enters the concentration tank, so that the concentration device provided by the invention has reduced energy consumption, at the same time residual contamination phenomenon can be avoided in the concentration process of simvastatin, and the interests of enterprises can be improved.

Description

technical field [0001] The invention relates to the technical field of simvastatin production, in particular to a concentration device for simvastatin production. Background technique [0002] Simvastatin was first developed by Merck, extracted from Aspergillus terreus, and entered medical use in 1992. The drug is listed in the World Health Organization's list of essential drugs and is an essential drug for the basic medical system One, as an oral blood lipid-lowering drug, the common trade name is "Zocor". This product will be taken during exercise, diet, and weight loss to avoid elevated blood lipids. In addition, simvastatin can also reduce high risk of heart disease. The chance of seizures, simvastatin belongs to the HMG-CoA reductase inhibitor, thereby inhibiting the liver to produce cholesterol. During the production process of simvastatin, it needs to be concentrated and purified many times. The existing concentration device for simvastatin production has a complicate...

AI Technical Summary

Problems solved by technology

[0002] Simvastatin was first developed by Merck, extracted from Aspergillus terreus, and entered medical use in 1992. The drug is listed in the World Health Organization's list of essential drugs and is an essential drug for the basic medical system One, as an oral blood lipid-lowering drug, the common trade name is "Zocor". This product will be taken during exercise, diet, and weight loss to avoid elevated blood lipids. In addition, simvastatin can also reduce high risk of heart disease. The chance of seizures, simvastatin belongs to the HMG-CoA reductase inhibitor, thereby inhibiting the liver to produce cholesterol. During the production process of simvastatin, it needs to be concentrated and purified many times. The existing concentration device for simvastatin production has a complicated structure and pipeline. It is not easy to clean, and it is easy to cause residual pollution during the concentration process of simvastatin. At the same time, the existing concentration device for simvastatin production has high energy consumption, which is not in the interests of the enterprise

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